NAAA - N-acylethanolamine acid amidase Gene

Also Known as PLT; ASAHL

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 27163

About NAAA

Cytogenetic location: 4q21.1 Genomic coordinates (GRCh38): 4:75,910,655-75,941,013 (from NCBI)

This gene has 9 transcripts (splice variants), 199 orthologues and 1 paralogue. Broad expression in prostate (RPKM 15.8), colon (RPKM 14.0) and 24 other tissues.

Summary

This gene encodes an N-acylethanolamine-hydrolyzing enzyme which is highly similar to acid Ceramidase. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

NAAA Products (3)

mRNA	Protein	Name
NM_001042402.2	NP_001035861.1	N-acylethanolamine-hydrolyzing acid amidase isoform 2 precursor
NM_001363719.2	NP_001350648.1	N-acylethanolamine-hydrolyzing acid amidase isoform 2 precursor
NM_014435.4	NP_055250.2	N-acylethanolamine-hydrolyzing acid amidase isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	21106534	GOA
enables N-(long-chain-acyl)ethanolamine deacylase activity	IDA IDA: Inferred from direct assay	15655246	GOA
enables N-acylsphingosine amidohydrolase activity	IDA IDA: Inferred from direct assay	15655246	GOA
enables fatty acid amide hydrolase activity	IDA IDA: Inferred from direct assay	15655246	GOA
enables hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	IDA IDA: Inferred from direct assay	17980170	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in N-acylethanolamine metabolic process	IDA IDA: Inferred from direct assay	15655246	GOA
involved in N-acylphosphatidylethanolamine metabolic process	IDA IDA: Inferred from direct assay	22825852	GOA
involved in fatty acid metabolic process	IDA IDA: Inferred from direct assay	15655246	GOA
involved in sphingosine metabolic process	IDA IDA: Inferred from direct assay	15655246	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	10610717	GOA
located in lysosome	IDA IDA: Inferred from direct assay	15655246	GOA
located in membrane	IDA IDA: Inferred from direct assay	30301806	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NAAA Protein Structure

NAAA-beta

CBAH

0
100
200
300
359 a.a.

Protein Preferred Names	Protein Names
N-acylethanolamine-hydrolyzing acid amidase	ASAH-like protein

Related Diseases

Diseases	Alias
Bleeding Disorder, Platelet-Type, 12	BDPLT12 Prostaglandin-Endoperoxide Synthase 1 Deficiency, Platelet Pghs1 Deficiency Platelet Cyclooxygenase 1 Deficiency Platelet Cox1 Deficiency Platelet-Type Bleeding Disorder 12 Platelet Prostaglandin-Endoperoxide Synthase 1 Deficiency
Vulvar Syringoma
Noonan Syndrome 10	NS10 Noonan Syndrome, Type 10
Charcot-Marie-Tooth Disease, Type 4j	Charcot-Marie-Tooth Disease Type 4j CMT4J Charcot-Marie-Tooth Disease, Autosomal Recessive, Type 4j Autosomal Recessive Charcot-Marie-Tooth Disease Type 4j Charcot-Marie-Tooth Disease 4j
Yunis-Varon Syndrome	Cleidocranial Dysplasia With Micrognathia, Absent Thumbs, And Distal Aphalangia Yunis Varon Syndrome YVS Cleidocranial Dysplasia-Micrognathia-Absent Thumbs Syndrome Cleidocranial Dysplasia, Micrognathia, Absent Thumbs, & Distal Aphalangia Yunis-Varón Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-B0182	Carmofur	Inhibitor	99.95%	Unkown

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-121975	N-Cyclohexanecarbonylpentadecylamine		98.68%	Phase 1

Pre-clinical Phase

Bioactive Molecules (17)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-W074890	Palmitoylglycine	Modulator	99.84%	Unkown
HY-145339	ARN19702	Inhibitor	99.69%	Unkown
HY-120813	ARN 077	Inhibitor	99.82%	Unkown
HY-124597	ARN726	Inhibitor	98.10%	Unkown
HY-185011	AM9053		98.36%	Unkown
HY-147773	NAAA-IN-1	Inhibitor	99.65%	Unkown
HY-147775	NAAA-IN-3	Inhibitor	98.20%	Unkown
HY-120813A	ARN 077 (enantiomer)		99.40%	Unkown
HY-132882	ARN19689	Inhibitor	/	Unkown
HY-125384	ARN14686		/	Unkown
HY-157223	ARN16186	Inhibitor	/	Unkown
HY-D2338	PMBD		/	Unkown
HY-N15826	RBM1-151	Substrate	/	Unkown
HY-RS08993	NAAA Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-169834	NAAA-IN-6	Inhibitor	/	Unkown
HY-RS18776	Naaa Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25264	Naaa Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	NAAA	VGNC	VGNC:75068
Mus musculus	NAAA	MGD	MGI:1914361
Felis catus	NAAA	VGNC	VGNC:68327
Bos taurus	NAAA	VGNC	VGNC:31854
Rattus norvegicus	NAAA	RGD	RGD:1307267
Others	NAAA	NCBI