DIMT1 - DIM1 rRNA methyltransferase and ribosome maturation factor Gene

Also Known as DIM1; DIMT1L; HUSSY5; HSA9761

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 27292

About DIMT1

Cytogenetic location: 5q12.1 Genomic coordinates (GRCh38): 5:62,387,254-62,403,905 (from NCBI)

This gene has 18 transcripts (splice variants), 212 orthologues and 2 paralogues. Ubiquitous expression in urinary bladder (RPKM 12.5), lymph node (RPKM 11.7) and 25 other tissues.

Summary

The protein encoded by this gene is a methyltransferase that is responsible for dimethylation of adjacent adenosines near the 18S rRNA decoding site. The encoded protein is essential for ribosome biogenesis, although its catalytic activity is not involved in the process. The yeast ortholog of this protein functions in the cytoplasm while this protein functions in the nucleus. [provided by RefSeq, Jan 2017]

DIMT1 Products (3)

mRNA Protein Name
NM_001348076.2 NP_001335005.1 probable dimethyladenosine transferase isoform 2
NM_001348077.2 NP_001335006.1 probable dimethyladenosine transferase isoform 3
NM_014473.4 NP_055288.1 probable dimethyladenosine transferase isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables 18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase activity IMP
IMP: Inferred from mutant phenotype
25851604 GOA
enables rRNA (adenine-N6,N6-)-dimethyltransferase activity EXP
EXP: Inferred from Experiment
25851604 GOA
Biological Process GO Annotation Evidence References Source
involved in positive regulation of rRNA processing IMP
IMP: Inferred from mutant phenotype
25851604 GOA
involved in rRNA methylation IMP
IMP: Inferred from mutant phenotype
25851604 GOA
involved in ribosomal small subunit biogenesis IDA
IDA: Inferred from direct assay
34516797 GOA
Cellular Component GO Annotation Evidence References Source
located in nucleolus IDA
IDA: Inferred from direct assay
25851604 GOA
part of small-subunit processome IDA
IDA: Inferred from direct assay
34516797 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DIMT1 Protein Structure

RrnaAD

RrnaAD: Ribosomal RNA adenine dimethylase (31 - 263)

  • 0
  • 100
  • 200
  • 313 a.a.
Protein Preferred Names Protein Names

probable dimethyladenosine transferase

  • 18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase

Related Diseases

Diseases Alias
Localized Osteosarcoma

  • Localised Osteogenic Sarcoma

  • Localised Osteosarcoma

  • Localized Osteogenic Sarcoma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03768 DIMT1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus DIMT1 VGNC VGNC:28065
Macaca mulatta DIMT1 VGNC VGNC:71818
Felis catus DIMT1 VGNC VGNC:61491
Rattus norvegicus DIMT1 RGD RGD:1311752
Canis familiaris DIMT1 VGNC VGNC:52127
Mus musculus DIMT1 MGD MGI:1913504
Others DIMT1 NCBI