Add3 - adducin 3 (gamma) Gene

Species: Mus musculus

Gene Type: protein coding
Gene ID: 27360

Summary

A structural constituent of Cytoskeleton. Predicted to be involved in barbed-end actin filament capping; positive regulation of vasoconstriction; and response to xenobiotic stimulus. Located in several cellular components, including brush border; condensed nuclear chromosome; and postsynaptic density. Is expressed in central nervous system; chondrocranium; gut; tail unsegmented mesenchyme; and vertebral axis musculature. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 50. Orthologous to human ADD3 (adducin 3). [provided by Alliance of Genome Resources, Apr 2022]

Add3 Products (7)

mRNA Protein Name
NM_001164099.3 NP_001157571.1 gamma-adducin isoform a
NM_001164100.3 NP_001157572.1 gamma-adducin isoform b
NM_001164101.3 NP_001157573.1 gamma-adducin isoform b
NM_001277100.2 NP_001264029.1 gamma-adducin isoform a
NM_001413986.1 NP_001400915.1 gamma-adducin isoform a
NM_001413987.1 NP_001400916.1 gamma-adducin isoform b
NM_013758.5 NP_038786.2 gamma-adducin isoform a

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables structural constituent of cytoskeleton IDA
IDA: Inferred from direct assay
10485892 MGI
Cellular Component GO Annotation Evidence References Source
located in brush border IDA
IDA: Inferred from direct assay
22114352 MGI
located in cell cortex IDA
IDA: Inferred from direct assay
1864459 MGI
located in cell-cell junction IDA
IDA: Inferred from direct assay
1864459 MGI
located in condensed nuclear chromosome IDA
IDA: Inferred from direct assay
1864459 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
1864459 MGI
located in cytoskeleton IDA
IDA: Inferred from direct assay
10485892 MGI
located in membrane IDA
IDA: Inferred from direct assay
10485892 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

gamma-adducin

  • adducin-like protein 70

  • cytoskeletal protein

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00340 ADD3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Add3 NCBI NCBI:120