Abcb11 - ATP-binding cassette, sub-family B (MDR/TAP), member 11 Gene

Mus musculus

Also known as Bsep; PGY4; SPGP; ABC16; Lith1; PFIC2

Gene ID: 27413 | Gene type: protein coding

About Abcb11

Summary

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is the major canalicular bile salt transporter in humans and mice. Mutations in the human gene cause a form of progressive familial intrahepatic cholestases which are a group of inherited disorders with severe cholestatic liver disease from early infancy. [provided by RefSeq, Jul 2008]

Abcb11 Products(2)

mRNA	Protein	Name
NM_001363492.1	NP_001350421.1	bile salt export pump
NM_021022.3	NP_066302.2	bile salt export pump

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables bile acid transmembrane transporter activity	IMP IMP: Inferred from mutant phenotype	20398791	MGI
enables canalicular bile acid transmembrane transporter activity	IMP IMP: Inferred from mutant phenotype	23764895	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in bile acid and bile salt transport	IMP IMP: Inferred from mutant phenotype	11172067	MGI
involved in canalicular bile acid transport	IMP IMP: Inferred from mutant phenotype	11172067	MGI
involved in cholesterol homeostasis	IMP IMP: Inferred from mutant phenotype	11172067	MGI
involved in fatty acid metabolic process	IMP IMP: Inferred from mutant phenotype	22619174	MGI
involved in lipid homeostasis	IMP IMP: Inferred from mutant phenotype	22619174	MGI
involved in phospholipid homeostasis	IMP IMP: Inferred from mutant phenotype	11172067	MGI
involved in positive regulation of bile acid secretion	IMP IMP: Inferred from mutant phenotype	11172067	MGI
involved in regulation of bile acid metabolic process	IMP IMP: Inferred from mutant phenotype	23764895	MGI
involved in regulation of fatty acid beta-oxidation	IMP IMP: Inferred from mutant phenotype	22619174	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in apical part of cell	IDA IDA: Inferred from direct assay	15040800	MGI
located in intercellular canaliculus	IDA IDA: Inferred from direct assay	12068294	MGI
located in membrane	IDA IDA: Inferred from direct assay	11279518	MGI
located in plasma membrane	IMP IMP: Inferred from mutant phenotype	24643070	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

bile salt export pump

ATP-binding cassette, sub-family B, member 11

sister of P-glycoprotein

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00050	ABCB11 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-D3304	Cholyl-L-lysine fluorescein disodium		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Abcb11	NCBI	NCBI:8647

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