Naglu - alpha-N-acetylglucosaminidase (Sanfilippo disease IIIB) Gene

Species: Mus musculus

Gene Type: protein coding
Gene ID: 27419

Summary

Predicted to enable alpha-N-acetylglucosaminidase activity. Acts upstream of or within several processes, including cerebellar Purkinje cell layer development; locomotor rhythm; and sensory organ development. Predicted to be located in extracellular exosome. Used to study mucopolysaccharidosis III and otitis media. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease axonal type 2V; mucopolysaccharidosis III; and mucopolysaccharidosis type IIIB. Orthologous to human NAGLU (N-acetyl-alpha-glucosaminidase). [provided by Alliance of Genome Resources, Apr 2022]

Naglu Products (1)

mRNA Protein Name
NM_013792.2 NP_038820.2 alpha-N-acetylglucosaminidase precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables alpha-N-acetylglucosaminidase activity IMP
IMP: Inferred from mutant phenotype
10588735 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within Golgi organization IMP
IMP: Inferred from mutant phenotype
21037080 MGI
acts upstream of or within adult behavior IMP
IMP: Inferred from mutant phenotype
25524704 MGI
acts upstream of or within amyloid precursor protein metabolic process IMP
IMP: Inferred from mutant phenotype
25267636 MGI
acts upstream of or within aorta development IMP
IMP: Inferred from mutant phenotype
32428018 MGI
acts upstream of or within aorta morphogenesis IMP
IMP: Inferred from mutant phenotype
26147524 MGI
acts upstream of or within astrocyte activation IMP
IMP: Inferred from mutant phenotype
26607664 MGI
acts upstream of or within astrocyte differentiation IMP
IMP: Inferred from mutant phenotype
12111813 MGI
acts upstream of or within autophagy IMP
IMP: Inferred from mutant phenotype
26147524 MGI
acts upstream of or within cardiac muscle cell development IMP
IMP: Inferred from mutant phenotype
26147524 MGI
acts upstream of or within cell surface receptor signaling pathway via STAT IMP
IMP: Inferred from mutant phenotype
29624734 MGI
acts upstream of or within cellular lipid catabolic process IMP
IMP: Inferred from mutant phenotype
19409882 MGI
acts upstream of or within cellular response to organic cyclic compound IMP
IMP: Inferred from mutant phenotype
21037080 MGI
acts upstream of or within cellular response to oxidative stress IMP
IMP: Inferred from mutant phenotype
19409882 MGI
acts upstream of or within cerebellar Purkinje cell layer development IMP
IMP: Inferred from mutant phenotype
17712420 MGI
acts upstream of or within collagen metabolic process IMP
IMP: Inferred from mutant phenotype
26147524 MGI
acts upstream of or within cone retinal bipolar cell differentiation IMP
IMP: Inferred from mutant phenotype
26607664 MGI
acts upstream of or within cytoplasm organization IMP
IMP: Inferred from mutant phenotype
19416848 MGI
acts upstream of or within determination of adult lifespan IGI
IGI: Inferred from genetic interaction
22867887 MGI
acts upstream of or within determination of adult lifespan IMP
IMP: Inferred from mutant phenotype
25524704 MGI
acts upstream of or within endothelium development IMP
IMP: Inferred from mutant phenotype
21408219 MGI
acts upstream of or within exploration behavior IMP
IMP: Inferred from mutant phenotype
21635693 MGI
acts upstream of or within ganglioside metabolic process IMP
IMP: Inferred from mutant phenotype
21408219 MGI
acts upstream of or within gene expression IDA
IDA: Inferred from direct assay
19386237 MGI
acts upstream of or within gene expression IMP
IMP: Inferred from mutant phenotype
12111813 MGI
acts upstream of or within glycoprotein metabolic process IMP
IMP: Inferred from mutant phenotype
25267636 MGI
acts upstream of or within glycosaminoglycan metabolic process IMP
IMP: Inferred from mutant phenotype
19632871 MGI
acts upstream of or within hair follicle morphogenesis IMP
IMP: Inferred from mutant phenotype
19632871 MGI
acts upstream of or within heart development IMP
IMP: Inferred from mutant phenotype
26147524 MGI
acts upstream of or within heart valve development IMP
IMP: Inferred from mutant phenotype
26147524 MGI
involved in heparan sulfate proteoglycan catabolic process IMP
IMP: Inferred from mutant phenotype
10588735 MGI
acts upstream of or within heparan sulfate proteoglycan metabolic process IDA
IDA: Inferred from direct assay
15649123 MGI
acts upstream of or within heparan sulfate proteoglycan metabolic process IMP
IMP: Inferred from mutant phenotype
18509511 MGI
acts upstream of or within heparin metabolic process IMP
IMP: Inferred from mutant phenotype
12111813 MGI
acts upstream of or within hormone metabolic process IMP
IMP: Inferred from mutant phenotype
29624734 MGI
acts upstream of or within inflammatory response IMP
IMP: Inferred from mutant phenotype
18509511 MGI
acts upstream of or within inner ear receptor cell development IMP
IMP: Inferred from mutant phenotype
17712420 MGI
acts upstream of or within left ventricular cardiac muscle tissue morphogenesis IMP
IMP: Inferred from mutant phenotype
26147524 MGI
acts upstream of or within limb development IGI
IGI: Inferred from genetic interaction
22867887 MGI
acts upstream of or within liver development IMP
IMP: Inferred from mutant phenotype
19632871 MGI
acts upstream of or within locomotor rhythm IMP
IMP: Inferred from mutant phenotype
17712420 MGI
acts upstream of or within locomotory behavior IMP
IMP: Inferred from mutant phenotype
21635693 MGI
acts upstream of or within lysosome organization IMP
IMP: Inferred from mutant phenotype
17712420 MGI
acts upstream of or within maintenance of blood-brain barrier IMP
IMP: Inferred from mutant phenotype
21408219 MGI
acts upstream of or within microglia differentiation IMP
IMP: Inferred from mutant phenotype
18509511 MGI
acts upstream of or within microglial cell activation IMP
IMP: Inferred from mutant phenotype
26607664 MGI
acts upstream of or within middle ear morphogenesis IMP
IMP: Inferred from mutant phenotype
17712420 MGI
acts upstream of or within mitral valve morphogenesis IMP
IMP: Inferred from mutant phenotype
26147524 MGI
acts upstream of or within motor behavior IGI
IGI: Inferred from genetic interaction
22867887 MGI
acts upstream of or within multicellular organismal-level iron ion homeostasis IMP
IMP: Inferred from mutant phenotype
29624734 MGI
acts upstream of or within nerve development IGI
IGI: Inferred from genetic interaction
22867887 MGI
acts upstream of or within neurogenesis IMP
IMP: Inferred from mutant phenotype
12111813 MGI
acts upstream of or within neuroinflammatory response IMP
IMP: Inferred from mutant phenotype
26607664 MGI
acts upstream of or within proteasome-mediated ubiquitin-dependent protein catabolic process IMP
IMP: Inferred from mutant phenotype
19386237 MGI
acts upstream of or within protein metabolic process IMP
IMP: Inferred from mutant phenotype
17185018 MGI
acts upstream of or within protein oxidation IMP
IMP: Inferred from mutant phenotype
19409882 MGI
acts upstream of or within protein processing IMP
IMP: Inferred from mutant phenotype
18325808 MGI
acts upstream of or within proteoglycan metabolic process IMP
IMP: Inferred from mutant phenotype
25267636 MGI
acts upstream of or within response to disaccharide IMP
IMP: Inferred from mutant phenotype
26607664 MGI
acts upstream of or within response to lipopolysaccharide IMP
IMP: Inferred from mutant phenotype
29624734 MGI
acts upstream of or within response to wounding IMP
IMP: Inferred from mutant phenotype
12111813 MGI
acts upstream of or within retina development in camera-type eye IMP
IMP: Inferred from mutant phenotype
26607664 MGI
acts upstream of or within retinal rod cell development IMP
IMP: Inferred from mutant phenotype
17712420 MGI
acts upstream of or within rod bipolar cell differentiation IMP
IMP: Inferred from mutant phenotype
26607664 MGI
acts upstream of or within sequestering of iron ion IMP
IMP: Inferred from mutant phenotype
29624734 MGI
acts upstream of or within superoxide metabolic process IMP
IMP: Inferred from mutant phenotype
19409882 MGI
acts upstream of or within toll-like receptor 4 signaling pathway IMP
IMP: Inferred from mutant phenotype
29624734 MGI
acts upstream of or within vacuole organization IGI
IGI: Inferred from genetic interaction
22867887 MGI
acts upstream of or within vacuole organization IMP
IMP: Inferred from mutant phenotype
21408219 MGI
acts upstream of or within vasculature development IMP
IMP: Inferred from mutant phenotype
21408219 MGI
acts upstream of or within vesicle tethering IMP
IMP: Inferred from mutant phenotype
21037080 MGI
Cellular Component GO Annotation Evidence References Source
is active in lysosomal lumen IDA
IDA: Inferred from direct assay
15537895 MGI
is active in vacuole IMP
IMP: Inferred from mutant phenotype
26147524 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

alpha-N-acetylglucosaminidase

  • N-acetyl-glucosaminidase

  • alpha-N-acetylglucosaminidase, lysosomal

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-E70184 α-N-Acetylglucosaminidase / Unkown
HY-RS09011 NAGLU Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Naglu NCBI NCBI:4669