Naglu - alpha-N-acetylglucosaminidase (Sanfilippo disease IIIB) Gene

Mus musculus

Gene ID: 27419 | Gene type: protein coding

About Naglu

Summary

Predicted to enable alpha-N-acetylglucosaminidase activity. Acts upstream of or within several processes, including cerebellar Purkinje cell layer development; locomotor rhythm; and sensory organ development. Predicted to be located in extracellular exosome. Used to study mucopolysaccharidosis III and otitis media. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease axonal type 2V; mucopolysaccharidosis III; and mucopolysaccharidosis type IIIB. Orthologous to human NAGLU (N-acetyl-alpha-glucosaminidase). [provided by Alliance of Genome Resources, Apr 2022]

Naglu Products(1)

mRNA	Protein	Name
NM_013792.2	NP_038820.2	alpha-N-acetylglucosaminidase precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables alpha-N-acetylglucosaminidase activity	IMP IMP: Inferred from mutant phenotype	10588735	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within Golgi organization	IMP IMP: Inferred from mutant phenotype	21037080	MGI
acts upstream of or within adult behavior	IMP IMP: Inferred from mutant phenotype	25524704	MGI
acts upstream of or within amyloid precursor protein metabolic process	IMP IMP: Inferred from mutant phenotype	25267636	MGI
acts upstream of or within aorta development	IMP IMP: Inferred from mutant phenotype	32428018	MGI
acts upstream of or within aorta morphogenesis	IMP IMP: Inferred from mutant phenotype	26147524	MGI
acts upstream of or within astrocyte activation	IMP IMP: Inferred from mutant phenotype	26607664	MGI
acts upstream of or within astrocyte differentiation	IMP IMP: Inferred from mutant phenotype	12111813	MGI
acts upstream of or within autophagy	IMP IMP: Inferred from mutant phenotype	26147524	MGI
acts upstream of or within cardiac muscle cell development	IMP IMP: Inferred from mutant phenotype	26147524	MGI
acts upstream of or within cell surface receptor signaling pathway via STAT	IMP IMP: Inferred from mutant phenotype	29624734	MGI
acts upstream of or within cellular lipid catabolic process	IMP IMP: Inferred from mutant phenotype	19409882	MGI
acts upstream of or within cellular response to organic cyclic compound	IMP IMP: Inferred from mutant phenotype	21037080	MGI
acts upstream of or within cellular response to oxidative stress	IMP IMP: Inferred from mutant phenotype	19409882	MGI
acts upstream of or within cerebellar Purkinje cell layer development	IMP IMP: Inferred from mutant phenotype	17712420	MGI
acts upstream of or within collagen metabolic process	IMP IMP: Inferred from mutant phenotype	26147524	MGI
acts upstream of or within cone retinal bipolar cell differentiation	IMP IMP: Inferred from mutant phenotype	26607664	MGI
acts upstream of or within cytoplasm organization	IMP IMP: Inferred from mutant phenotype	19416848	MGI
acts upstream of or within determination of adult lifespan	IGI IGI: Inferred from genetic interaction	22867887	MGI
acts upstream of or within determination of adult lifespan	IMP IMP: Inferred from mutant phenotype	25524704	MGI
acts upstream of or within endothelium development	IMP IMP: Inferred from mutant phenotype	21408219	MGI
acts upstream of or within exploration behavior	IMP IMP: Inferred from mutant phenotype	21635693	MGI
acts upstream of or within ganglioside metabolic process	IMP IMP: Inferred from mutant phenotype	21408219	MGI
acts upstream of or within gene expression	IDA IDA: Inferred from direct assay	19386237	MGI
acts upstream of or within gene expression	IMP IMP: Inferred from mutant phenotype	12111813	MGI
acts upstream of or within glycoprotein metabolic process	IMP IMP: Inferred from mutant phenotype	25267636	MGI
acts upstream of or within glycosaminoglycan metabolic process	IMP IMP: Inferred from mutant phenotype	19632871	MGI
acts upstream of or within hair follicle morphogenesis	IMP IMP: Inferred from mutant phenotype	19632871	MGI
acts upstream of or within heart development	IMP IMP: Inferred from mutant phenotype	26147524	MGI
acts upstream of or within heart valve development	IMP IMP: Inferred from mutant phenotype	26147524	MGI
involved in heparan sulfate proteoglycan catabolic process	IMP IMP: Inferred from mutant phenotype	10588735	MGI
acts upstream of or within heparan sulfate proteoglycan metabolic process	IDA IDA: Inferred from direct assay	15649123	MGI
acts upstream of or within heparan sulfate proteoglycan metabolic process	IMP IMP: Inferred from mutant phenotype	18509511	MGI
acts upstream of or within heparin metabolic process	IMP IMP: Inferred from mutant phenotype	12111813	MGI
acts upstream of or within hormone metabolic process	IMP IMP: Inferred from mutant phenotype	29624734	MGI
acts upstream of or within inflammatory response	IMP IMP: Inferred from mutant phenotype	18509511	MGI
acts upstream of or within inner ear receptor cell development	IMP IMP: Inferred from mutant phenotype	17712420	MGI
acts upstream of or within left ventricular cardiac muscle tissue morphogenesis	IMP IMP: Inferred from mutant phenotype	26147524	MGI
acts upstream of or within limb development	IGI IGI: Inferred from genetic interaction	22867887	MGI
acts upstream of or within liver development	IMP IMP: Inferred from mutant phenotype	19632871	MGI
acts upstream of or within locomotor rhythm	IMP IMP: Inferred from mutant phenotype	17712420	MGI
acts upstream of or within locomotory behavior	IMP IMP: Inferred from mutant phenotype	21635693	MGI
acts upstream of or within lysosome organization	IMP IMP: Inferred from mutant phenotype	17712420	MGI
acts upstream of or within maintenance of blood-brain barrier	IMP IMP: Inferred from mutant phenotype	21408219	MGI
acts upstream of or within microglia differentiation	IMP IMP: Inferred from mutant phenotype	18509511	MGI
acts upstream of or within microglial cell activation	IMP IMP: Inferred from mutant phenotype	26607664	MGI
acts upstream of or within middle ear morphogenesis	IMP IMP: Inferred from mutant phenotype	17712420	MGI
acts upstream of or within mitral valve morphogenesis	IMP IMP: Inferred from mutant phenotype	26147524	MGI
acts upstream of or within motor behavior	IGI IGI: Inferred from genetic interaction	22867887	MGI
acts upstream of or within multicellular organismal-level iron ion homeostasis	IMP IMP: Inferred from mutant phenotype	29624734	MGI
acts upstream of or within nerve development	IGI IGI: Inferred from genetic interaction	22867887	MGI
acts upstream of or within neurogenesis	IMP IMP: Inferred from mutant phenotype	12111813	MGI
acts upstream of or within neuroinflammatory response	IMP IMP: Inferred from mutant phenotype	26607664	MGI
acts upstream of or within proteasome-mediated ubiquitin-dependent protein catabolic process	IMP IMP: Inferred from mutant phenotype	19386237	MGI
acts upstream of or within protein metabolic process	IMP IMP: Inferred from mutant phenotype	17185018	MGI
acts upstream of or within protein oxidation	IMP IMP: Inferred from mutant phenotype	19409882	MGI
acts upstream of or within protein processing	IMP IMP: Inferred from mutant phenotype	18325808	MGI
acts upstream of or within proteoglycan metabolic process	IMP IMP: Inferred from mutant phenotype	25267636	MGI
acts upstream of or within response to disaccharide	IMP IMP: Inferred from mutant phenotype	26607664	MGI
acts upstream of or within response to lipopolysaccharide	IMP IMP: Inferred from mutant phenotype	29624734	MGI
acts upstream of or within response to wounding	IMP IMP: Inferred from mutant phenotype	12111813	MGI
acts upstream of or within retina development in camera-type eye	IMP IMP: Inferred from mutant phenotype	26607664	MGI
acts upstream of or within retinal rod cell development	IMP IMP: Inferred from mutant phenotype	17712420	MGI
acts upstream of or within rod bipolar cell differentiation	IMP IMP: Inferred from mutant phenotype	26607664	MGI
acts upstream of or within sequestering of iron ion	IMP IMP: Inferred from mutant phenotype	29624734	MGI
acts upstream of or within superoxide metabolic process	IMP IMP: Inferred from mutant phenotype	19409882	MGI
acts upstream of or within toll-like receptor 4 signaling pathway	IMP IMP: Inferred from mutant phenotype	29624734	MGI
acts upstream of or within vacuole organization	IGI IGI: Inferred from genetic interaction	22867887	MGI
acts upstream of or within vacuole organization	IMP IMP: Inferred from mutant phenotype	21408219	MGI
acts upstream of or within vasculature development	IMP IMP: Inferred from mutant phenotype	21408219	MGI
acts upstream of or within vesicle tethering	IMP IMP: Inferred from mutant phenotype	21037080	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
is active in lysosomal lumen	IDA IDA: Inferred from direct assay	15537895	MGI
is active in vacuole	IMP IMP: Inferred from mutant phenotype	26147524	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

alpha-N-acetylglucosaminidase

N-acetyl-glucosaminidase

alpha-N-acetylglucosaminidase, lysosomal

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-E70184	α-N-Acetylglucosaminidase		/	Unkown
HY-RS09011	NAGLU Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Naglu	NCBI	NCBI:4669

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