GNAL - G protein subunit alpha L Gene

Also Known as HG1O; DYT25

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 2774

About GNAL

Cytogenetic location: 18p11.21 Genomic coordinates (GRCh38): 18:11,689,264-11,885,685 (from NCBI)

This gene has 10 transcripts (splice variants), 233 orthologues, 15 paralogues and is associated with 2 phenotypes. Ubiquitous expression in brain (RPKM 7.2), prostate (RPKM 5.5) and 24 other tissues.

Summary

This gene encodes a stimulatory G protein alpha subunit which mediates odorant signaling in the olfactory epithelium. This protein couples dopamine type 1 receptors and adenosine A2A receptors and is widely expressed in the central nervous system. Mutations in this gene have been associated with dystonia 25 and this gene is located in a susceptibility region for bipolar disorder and schizophrenia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]

GNAL Products (5)

mRNA	Protein	Name
NM_001142339.3	NP_001135811.1	guanine nucleotide-binding protein G(olf) subunit alpha isoform 2
NM_001261443.2	NP_001248372.1	guanine nucleotide-binding protein G(olf) subunit alpha isoform 2
NM_001261444.2	NP_001248373.1	guanine nucleotide-binding protein G(olf) subunit alpha isoform 3
NM_001369387.1	NP_001356316.1	guanine nucleotide-binding protein G(olf) subunit alpha isoform 2
NM_182978.4	NP_892023.1	guanine nucleotide-binding protein G(olf) subunit alpha isoform 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	23994616	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GNAL Protein Structure

G-alpha

0
100
200
300
381 a.a.

Protein Preferred Names	Protein Names
guanine nucleotide-binding protein G(olf) subunit alpha	adenylate cyclase-stimulating G alpha protein, olfactory type

Related Diseases

Diseases	Alias
Dystonia 25	DYT25 Dystonia-25 Dystonia, Type 25
Dyt-Gnal	Dyt25 Autosomal Dominant Focal Dystonia, Dyt25 Type Gnal-Related Dystonia Adult Onset Cranial-Cervical Dystonia Dystonia-25 Dystonia 25
Dystonia	Dystonic Disease Dystonic Disorder Dystonia Disorders Neuroleptic Dyskinesia
Pseudohypoparathyroidism	Familial Pseudohypoparathyroidism Parathyroid Hormone Resistant Hypoparathyroidism Php - [Pseudohypoparathyroidism] Constitutional Chronic Hypocalcaemia
Focal Dystonia	Dystonia, Focal, Task-Specific
Spasmodic Dystonia	Laryngeal Dystonia
Bipolar Disorder	Bipolar Depression Manic Disorder Depression, Bipolar Bipolar Disorder Manic Phase Depressive-Manic Psych. Manic Bipolar Affective Disorder Manic Bipolar I Disorder Manic Depression Manic Depressive Disorder Mixed Bipolar Disorder Bipolar Affective Disorder Bipolar Affective Psychosis Bipolar Spectrum Disorder Manic Depressive Illness Depression Bipolar Bipolar Disorder, Mixed Major Affective Disorder Major Affective Disorder 1 Major Affective Disorder 2
Segmental Dystonia
Dystonia 24	DYT24 Cranio-Cervical Dystonia With Laryngeal And Upper-Limb Involvement Dystonia-24 Dystonia, Type 24
Dystonia 12	DYT12 Rdp Generalized Dystonia Dystonia-12 Rapid-Onset Dystonia-Parkinsonism Familial Dystonia Dystonia Musculorum Deformans Dystonic Disorders Idiopathic Familial Dystonia Dystonia-Parkinsonism, Rapid-Onset Fragments Of Torsion Dystonia Dyt-Atp1a3 Rapid-Onset Dystonia Parkinsonism Rodp Dystonia, Type 12 Dystonia 3, Torsion, X-Linked Idiopathic Non-Familial Dystonia Symptomatic Torsion Dystonia Dystonia Disorders
Focal Hand Dystonia	Organic Writer'S Cramp Dystonia, Focal, Task-Specific
Torsion Dystonia 2	Dystonia 2, Torsion, Autosomal Recessive
Cervical Dystonia	Spasmodic Torticollis
Torsion Dystonia 4
Multifocal Dystonia
Dystonia 1, Torsion, Autosomal Dominant	Dystonia Musculorum Deformans 1 Dystonia Musculorum Deformans DYT1 Early-Onset Torsion Dystonia Eotd Dystonia-1, Torsion Torsion Dystonia 1 Autosomal Dominant Torsion Dystonia 1 Dystonia-1 Oppenheim'S Dystonia Oppenheim-Ziehen Disease Early Onset Torsion Dystonia Dystonia 3, Torsion, X-Linked
Hereditary Lymphedema Ii	Meige Syndrome Meige Disease Meige Lymphedema Hereditary Lymphedema Type Ii Lymphedema Hereditary Type 2 Lymphedema Praecox Lymphedema, Hereditary, Ii Blepharospasm-Oromandibular Dystonia Syndrome Meige Dystonia Meige'S Syndrome Late-Onset Lymphedema Lmph2 Lymphedema Preacox Lymphedema, Late-Onset Blepharospasm - Oromandibular Dystonia Blepharospasm-Oromandibular Dystonia Brueghel Syndrome Idiopathic Blepharospasm-Oromandibular Dystonia Syndrome Oral Facial Dystonia Segmental Cranial Dystonia Meigs Syndrome
Schizophrenia	SCZD Schizophrenia With Or Without An Affective Disorder Schizophrenia 12 Schizophrenia, Susceptibility To Schizophrenia-1 Dementia Praecox Schizophrenia 1
Blepharospasm
Oromandibular Dystonia
Lymphatic Malformation 5	Meige Syndrome Meige Disease Meige Lymphedema Lymphedema Praecox Lymphedema, Late-Onset Late-Onset Lymphedema LMPH2 Meigs Syndrome LMPHM5 Lymphedema, Hereditary, Ii, Formerly Lmph2, Formerly Hereditary Lymphedema Ii Demons-Meigs Syndrome Hereditary Lymphedema Type Ii Lymphedema, Hereditary, 2 Lymphedema, Hereditary, Ii Meige'S Disease
Dystonia 27	DYT27 Primary Dystonia, Dyt27 Type Dystonia, Type 27
Hemidystonia
Developmental And Epileptic Encephalopathy 17	DEE17 Epileptic Encephalopathy, Early Infantile, 17 Eiee17 Developmental And Epileptic Encephalopathy, 17 Early Infantile Epileptic Encephalopathy 17 Developmental And Epileptic Encephalopathy, Type 17
Leukodystrophy, Hypomyelinating, 6	Habc Hypomyelinating Leukodystrophy 6 HLD6 H-Abc Hypomyelination With Atrophy Of Basal Ganglia And Cerebellum Leukodystrophy, Hypomyelinating, With Atrophy Of The Basal Ganglia And Cerebellum Hypomyelinating Leukodystrophy With Atrophy Of The Basal Ganglia And Cerebellum HLD Leukodystrophy, Hypomyelinating, Type 6
Major Depressive Disorder	Seasonal Affective Disorder Unipolar Depression Depression MDD Depressive Disorder Unipolar Depression, Susceptibility To Major Depressive Disorder 1 Major Depressive Disorder, Response To Citalopram Therapy In Major Depressive Disorder 2 Winter Depression Single Major Depressive Episode Sad Clinical Depression Major Depression Depressive Syndrome Major Depressive Disorder And Accelerated Response To Antidepressant Drug Treatment Seasonal Affective Disorder, Susceptibility To Recurrent Major Depression Affective Disorder, Seasonal Depression In A Seasonal Pattern Depression Seasonal Major Depressive Disorder With A Seasonal Pattern Seasonal Depression Seasonal Mood Disorder Mental Depression Recurrent Major Depressive Episodes
Dystonia 11, Myoclonic	Myoclonic Dystonia Myoclonus-Dystonia Syndrome DYT11 Myoclonic Dystonia 11 Alcohol-Responsive Dystonia Myoclonus, Hereditary Essential Dystonia-11, Myoclonic Myoclonus-Dystonia Dystonia 11 Hereditary Essential Myoclonus Dystonia, Alcohol-Responsive Dyt-Sgce Dystonia, Alcohol Responsive Dystonia-11 Dystonia, Myoclonic Dystonia, Myoclonic, Type 11
Mood Disorder	Mood Disorders Episodic Mood Disorder
Movement Disease	Movement Disorders Movement Disorder
Alternating Hemiplegia Of Childhood	Alternating Hemiplegia Ahc Alternating Hemiplegia Syndrome Hemiplegia, Alternating, Of Childhood Hemiplegia, Crossed
Choreatic Disease	Chorea Hereditary Chorea

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05537	GNAL Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17331	Gnal Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23786	Gnal Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	GNAL	VGNC	VGNC:29452
Felis catus	GNAL	VGNC	VGNC:62618
Macaca mulatta	GNAL	VGNC	VGNC:104224
Mus musculus	GNAL	MGD	MGI:95774
Canis familiaris	GNAL	VGNC	VGNC:41304
Rattus norvegicus	GNAL	RGD	RGD:2715
Others	GNAL	NCBI