GP9 - glycoprotein IX platelet Gene

Also Known as GPIX; CD42a

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 2815

About GP9

Cytogenetic location: 3q21.3 Genomic coordinates (GRCh38): 3:129,054,845-129,062,406 (from NCBI)

This gene has 1 transcript (splice variant), 160 orthologues, 1 paralogue and is associated with 2 phenotypes. Biased expression in bone marrow (RPKM 1.0), spleen (RPKM 0.7) and 4 other tissues.

Summary

This gene encodes a small membrane glycoprotein found on the surface of human platelets. It forms a 1-to-1 noncovalent complex with glycoprotein Ib, a platelet surface membrane glycoprotein complex that functions as a receptor for von Willebrand factor. The complete receptor complex includes noncovalent association of the alpha and beta subunits with the protein encoded by this gene and platelet glycoprotein V. Defects in this gene are a cause of Bernard-Soulier syndrome, also known as giant platelet disease. These patients have unusually large platelets and have a clinical bleeding tendency. [provided by RefSeq, Oct 2008]

GP9 Products (1)

mRNA	Protein	Name
NM_000174.5	NP_000165.1	platelet glycoprotein IX precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	1730602	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in blood coagulation, intrinsic pathway	IPI IPI: Inferred from physical interaction	10501658	GOA
involved in positive regulation of platelet activation	IDA IDA: Inferred from direct assay	1939645	GOA
involved in release of sequestered calcium ion into cytosol	IDA IDA: Inferred from direct assay	1939645	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of glycoprotein Ib-IX-V complex	IPI IPI: Inferred from physical interaction	1730602	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GP9 Protein Structure

LRRNT

LRR_8

0
100
177 a.a.

Protein Preferred Names	Protein Names
platelet glycoprotein IX	glycoprotein 9

GP9 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	GP9	P14770	GP5	Homo sapiens	P40197	Anti Bait CoIP	1730602
Intra	GP9	P14770	HOXA1	Homo sapiens	P49639	Y2H Array	25416956
Intra	GP9	P14770	HOXA1	Homo sapiens	P49639	Y2H Prey Pooling	25416956
Intra	GP9	P14770	HOXA1	Homo sapiens	P49639	Y2H Array	31515488
Intra	GP9	P14770	SPRY2	Homo sapiens	O43597	Y2H Prey Pooling	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant GP9 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P77953	CD42a/GP9 Protein, Human (HEK293, Fc)	P14770 (T17-G147)	≥ 95%, as determined by Bis-Tris PAGE.

GP9 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80059	CD42a Antibody (YA804)	WB, IHC-P	Human, Mouse, Rat
HY-P84099	CD42a Antibody (YA3796)	WB, IHC-P, FC, ELISA	Human, Mouse
HY-P84099A	CD42a Antibody (YA3796)(PBS only)	WB, IHC-P, FC, ELISA	Human, Mouse
HY-P86807	CD42a Antibody (YA6500)	WB, IHC-P	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Bernard-Soulier Syndrome	Giant Platelet Syndrome BSS Von Willebrand Factor Receptor Deficiency Bdplt1 Platelet Glycoprotein Ib Deficiency Bernard-Soulier Syndrome, Type A1 Bernard-Soulier Syndrome, Type B Bernard Soulier Syndrome Deficiency Of Platelet Glycoprotein 1b Hemorrhagiparous Thrombocytic Dystrophy Bernard-Soulier Syndrome Type C Bleeding Disorder, Platelet-Type, 1 Glycoprotein Ib, Platelet, Deficiency Of Giant Platelet Disorder, Isolated Giant Platelet Disease Macrothrombocytopenia, Familial Bernard-Soulier Type Bernard-Soulier Syndrome, Type C Bernard - Soulier Thrombopathy Hemorrhagic Dystrophic Thrombocytopenia Thrombopathy, Bernard-Soulier Platelet Glycoprotein 1b, Deficiency Of Hemorrhagioparous Thrombocytic Dystrophy Bernard-Soulier Syndrome Type A1 Bernard-Soulier Syndrome Type B Bleeding Disorder Platelet-Type 1 Gpd Macrothrombocytopenia, Familial, Bernard-Soulier Type
Thrombocytopenia	Low Platelet Count Low Platelets Decreased Platelets Platelet Dysfunction Nos
Gray Platelet Syndrome	Platelet Alpha-Granule Deficiency GPS Bdplt4 Bleeding Disorder, Platelet-Type, 4 Grey Platelet Syndrome Platelet-Type Bleeding Disorder 4 Marked Decrease Or Absence Of Alpha-Granules And Of Platelet-Specific Alpha-Granule Proteins Deficient Alpha Granule Syndrome Platelet Alpha Granule Deficiency Platelet Granule Defect Alpha Storage Pool Deficiency Bleeding Disorder Platelet-Type 4
Blood Platelet Disease	Platelet Disorder Blood Platelet Disorders Thrombocytopathy Platelet Dysfunction Platelet Disorders Qualitative Platelet Deficiency
Pseudo-Von Willebrand Disease	Bdplt3 Von Willebrand Disease, Platelet-Type VWDP Platelet-Type Bleeding Disorder 3 Platelet Type-Von Willebrand Disease Pt-Vwd Von Willebrand Disease Platelet-Type Von Willebrand Disease, Platelet Type Pseudo Von Willebrand Disease Bleeding Disorder, Platelet-Type, 3 Pseudo-Von Willebrand Disease Type 2b Bleeding Disorder Platelet-Type 3 Pseudo-Vwd
Myopathy, Tubular Aggregate, 1	Tubular Aggregate Myopathy Tam Myopathy With Tubular Aggregates TAM1 Myopathy, Tubular Aggregate Tubular Aggregate Myopathy 1
Thrombasthenia
Bardet-Biedl Syndrome 5	BBS5 Bardet-Biedl Syndrome, Type 5
Hemophilia B	Christmas Disease Factor Ix Deficiency F9 Deficiency HEMB Plasma Thromboplastin Component Deficiency Congenital Factor Ix Deficiency Mild Hemophilia B Severe Hemophilia B Congenital Factor Ix Disorder Deficiency, Functional Factor Ix Hem B Mild Congenital F9 Deficiency Mild Congenital Factor Ix Deficiency Moderate Hemophilia B Moderate Congenital F9 Deficiency Moderate Congenital Factor Ix Deficiency Severe Congenital F9 Deficiency Severe Congenital Factor Ix Deficiency Bleeding Disorder In Hemophilia B Carriers Congenital F9 Deficiency Recessive X-Linked Hemophilia B
Acrokeratoderma, Hereditary Papulotranslucent	Hereditary Papulotranslucent Acrokeratoderma
Jacobsen Syndrome	Chromosome 11q Deletion Syndrome Partial 11q Monosomy Syndrome Jacobsen Distal 11q Deletion Syndrome JBS 11q Partial Monosomy Syndrome Chromosome 11q Deletion 11q Deletion 11q Monosomy Deletion 11q Monosomy 11q Partial Monosomy 11q 11q Deletion Disorder 11q Deletion Syndrome 11q Terminal Deletion Disorder 11q- Deletion Syndrome 11q23 Deletion Disorder Jacobsen Thrombocytopenia 11q Terminal Deletion Syndrome Del(11)(Q23.3) Del(11)(Qter) Distal Deletion 11q Distal Monosomy 11q Monosomy 11qter Telomeric Deletion 11q Paris-Trousseau Thrombocytopenia
Glanzmann Thrombasthenia 1	Glanzmann Thrombasthenia Thrombasthenia Of Glanzmann And Naegeli Glanzmann'S Thrombasthenia Bdplt2 Platelet Glycoprotein Iib-Iiia Deficiency Deficiency Of Platelet Fibrinogen Receptor GT1 Gt Platelet Fibrinogen Receptor Deficiency Glycoprotein Complex Iib-Iiia Deficiency Deficiency Of Glycoprotein Complex Iib-Iiia Glycoprotein Iib/Iiia Defect Glanzmann Thrombasthenia, Type A Thrombasthenia Bleeding Disorder, Platelet-Type, 2 Gp Iib-Iiia Complex Deficiency Deficiency Of Gp Iib-Iiia Complex Platelet-Type Bleeding Disorder 2 Thrombocytasthenia Deficiency Of Gp 2b 3a Complex Diacyclothrombopathia 2b 3a Glanzmann Thrombasthenia Type A Platelet Fibrinogen Receptor, Deficiency Of Platelet Glycoprotein 2b 3a Deficiency Glanzmann Disease Glanzmann-Naegeli Disorder Hereditary Hemorrhagic Thrombasthenia Hereditary Thrombasthenia Bleeding Disorder Platelet-Type 2
Thrombocytopenia Due To Platelet Alloimmunization	Immune Thrombocytopenia Autoimmune Thrombocytopenia Immune Thrombocytopenic Purpura Itp Auto-Immune Thrombocytopenia Thrombocytopenia Due To Immune Destruction Autoimmune Thrombocytopenic Purpura Idiopathic Thrombocytopenic Purpura Werlhof Disease
Myh-9 Related Disease	Myh9-Related Disease Myh9-Rd Myh9-Related Disorder Myh9-Related Syndrome Myh9-Related Syndromic Thrombocytopenia Sebastian Syndrome
Von Willebrand'S Disease	Von Willebrand Disease Von Willebrand Disorder Vascular Pseudohemophilia Hereditary Von Willebrand Disease Vwd Vascular Hemophilia Von Willebrand'S-Jurgens' Disease Von Willebrand-Jrgens Disease Von Willebrand Factor Deficiency Von Willebrand Factor, Deficiency Angiohemophilia Von Willebrand'S Factor Deficiency Von Willebrand Diseases Factor Viii Deficiency With Vascular Defect Vascular Haemophilia Willebrand Jurgen Thrombopathy Pseudohaemophilia Minot-Von Willebrand-Jurgen Disease Angiohaemophilia Angiohaemophilia A Angiohaemophilia B
Blood Coagulation Disease	Blood Coagulation Disorders Coagulation Protein Disease Inherited Blood Coagulation Disease Postpartum Coagulation Defect Postpartum Coagulation Defect With Delivery Coagulation Protein Disorders Puerperal Coagulopathy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05612	GP9 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18326	Gp9 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24805	Gp9 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	GP9	VGNC	VGNC:29507
Rattus norvegicus	GP9	RGD	RGD:1561601
Mus musculus	GP9	MGD	MGI:1860137
Felis catus	GP9	VGNC	VGNC:67399
Canis familiaris	GP9	VGNC	VGNC:41357
Macaca mulatta	GP9	VGNC	VGNC:73115
Others	GP9	NCBI