GP5 - glycoprotein V platelet Gene

Also Known as GPV; CD42d

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 2814

About GP5

Cytogenetic location: 3q29 Genomic coordinates (GRCh38): 3:194,394,821-194,399,266 (from NCBI)

This gene has 2 transcripts (splice variants), 157 orthologues and 25 paralogues. Low expression observed in reference dataset.

Summary

Human platelet glycoprotein V (GP5) is a part of the Ib-V-IX system of surface glycoproteins that constitute the receptor for von Willebrand factor (VWF; MIM 613160) and mediate the adhesion of platelets to injured vascular surfaces in the arterial circulation, a critical initiating event in hemostasis. The main portion of the receptor is a heterodimer composed of 2 polypeptide chains, an alpha chain (GP1BA; MIM 606672) and a beta chain (GP1BB; MIM 138720), that are linked by disulfide bonds. The complete receptor complex includes noncovalent association of the alpha and beta subunits with platelet glycoprotein IX (GP9; MIM 173515) and GP5. Mutations in GP1BA, GP1BB, and GP9 have been shown to cause Bernard-Soulier syndrome (MIM 231200), a bleeding disorder (review by Lopez et al., 1998 [PubMed 9616133]).[supplied by OMIM, Nov 2010]

GP5 Products (1)

mRNA	Protein	Name
NM_004488.2	NP_004479.1	platelet glycoprotein V precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	1730602	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in blood coagulation, intrinsic pathway	IPI IPI: Inferred from physical interaction	10501658	GOA
involved in positive regulation of platelet activation	IDA IDA: Inferred from direct assay	1939645	GOA
involved in release of sequestered calcium ion into cytosol	IDA IDA: Inferred from direct assay	1939645	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of glycoprotein Ib-IX-V complex	IPI IPI: Inferred from physical interaction	1730602	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GP5 Protein Structure

LRR_8

LRR_1

LRR_8

0
100
200
300
400
500
560 a.a.

Protein Preferred Names	Protein Names
platelet glycoprotein V	glycoprotein 5

GP5 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	GP5	P40197	GP9	Homo sapiens	P14770	Anti Bait CoIP	1730602

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Bernard-Soulier Syndrome	Giant Platelet Syndrome BSS Von Willebrand Factor Receptor Deficiency Bdplt1 Platelet Glycoprotein Ib Deficiency Bernard-Soulier Syndrome, Type A1 Bernard-Soulier Syndrome, Type B Bernard Soulier Syndrome Deficiency Of Platelet Glycoprotein 1b Hemorrhagiparous Thrombocytic Dystrophy Bernard-Soulier Syndrome Type C Bleeding Disorder, Platelet-Type, 1 Glycoprotein Ib, Platelet, Deficiency Of Giant Platelet Disorder, Isolated Giant Platelet Disease Macrothrombocytopenia, Familial Bernard-Soulier Type Bernard-Soulier Syndrome, Type C Bernard - Soulier Thrombopathy Hemorrhagic Dystrophic Thrombocytopenia Thrombopathy, Bernard-Soulier Platelet Glycoprotein 1b, Deficiency Of Hemorrhagioparous Thrombocytic Dystrophy Bernard-Soulier Syndrome Type A1 Bernard-Soulier Syndrome Type B Bleeding Disorder Platelet-Type 1 Gpd Macrothrombocytopenia, Familial, Bernard-Soulier Type
Penile Cancer	Penis Carcinoma Carcinoma Of Penis Penile Neoplasm Penile Carcinoma Penile Neoplasms Malignant Neoplasm Of Penis Ca Penis Malignant Neoplasm Of Body Of Penis Malignant Penile Tumor Penile Ca
Ureter Inverted Papilloma	Ureteral Inverted Papilloma
Ureter Urothelial Papilloma
Thrombocytopenia Due To Platelet Alloimmunization	Immune Thrombocytopenia Autoimmune Thrombocytopenia Immune Thrombocytopenic Purpura Itp Auto-Immune Thrombocytopenia Thrombocytopenia Due To Immune Destruction Autoimmune Thrombocytopenic Purpura Idiopathic Thrombocytopenic Purpura Werlhof Disease
Gray Platelet Syndrome	Platelet Alpha-Granule Deficiency GPS Bdplt4 Bleeding Disorder, Platelet-Type, 4 Grey Platelet Syndrome Platelet-Type Bleeding Disorder 4 Marked Decrease Or Absence Of Alpha-Granules And Of Platelet-Specific Alpha-Granule Proteins Deficient Alpha Granule Syndrome Platelet Alpha Granule Deficiency Platelet Granule Defect Alpha Storage Pool Deficiency Bleeding Disorder Platelet-Type 4
Uterus Carcinoma In Situ
Cervical Adenosarcoma	Cervical Muellerian Adenosarcoma Cervical Mullerian Adenosarcoma
Blood Platelet Disease	Platelet Disorder Blood Platelet Disorders Thrombocytopathy Platelet Dysfunction Platelet Disorders Qualitative Platelet Deficiency
Cervix Uteri Carcinoma In Situ	Carcinoma In Situ Of Cervix Carcinoma In Situ Of Uterine Cervix Cervical Intraepithelial Neoplasia Carcinoma Of Cervix Stage 0 Cervical Intraepithelial Neoplasia Grade Iii With Severe Dysplasia Cervix Ca In Situ Cin Iii Cin Iii - Carcinoma In Situ Of Cervix Cin Iii - Severe Dyskaryosis Severe Dysplasia Of Cervix Severe Dysplasia Of The Cervix Uteri Squamous Intraepithelial Neoplasia, Grade Iii Cervix Intraepithelial Neoplasia Grade 3 Ajcc V7
Penis Basal Cell Carcinoma	Basal Cell Carcinoma Of The Penis
Inverted Follicular Keratosis	Inverted Folicular Keratosis Seborrheic Keratosis
Penile Benign Neoplasm	Neoplasm Of Penis Penile Tumor Cancer Of Penis Carcinoma Of Penis Malignant Neoplasm Of Penis, Unspecified Malignant Neoplasm Of Penis, Part Unspecified Malignant Tumour Of Penis Penile Cancer Primary Malignant Neoplasm Of Penis Malignant Neoplasm Of Skin Of Penis Nos
Focal Epithelial Hyperplasia	Heck'S Disease Heck Disease Multifocal Epithelial Hyperplasia
Vulva Cancer	Vulvar Carcinoma Malignant Neoplasm Of Vulva Vulva Carcinoma Carcinoma Of Vulva Vulvar Cancer Vulval Cancer Vulvar Neoplasms Ca Vulva Malignant Tumor Of Vulva Malignant Vulvar Tumor Neoplasm Of Vulva Vulval Neoplasm Vulvar Neoplasm Vulvar Tumor Cancer Of Vulva Malignant Tumour Of Vulva
Anogenital Venereal Wart	Genital Warts Condylomata Acuminata Anogenital Warts Condyloma Acuminatum Anogenital Human Papilloma Virus Infectious Disease Genital Wart Virus Infectious Disease Venereal Wart Venereal Warts Verrucae Anogenitales Verrucae Genitales
Anus Cancer	Anal Cancer Anal Carcinoma Malignant Anal Tumor Cancer Of The Anus Malignant Neoplasm Of Anus Anus Neoplasms
Chronic Cervicitis
Middle Ear Squamous Cell Carcinoma	Squamous Cell Carcinoma Of Middle Ear Epidermoid Carcinoma Of The Middle Ear
Vaginal Cancer	Malignant Neoplasm Of Vagina Vaginal Neoplasms Malignant Tumor Of Vagina Malignant Vaginal Tumor Neoplasm Of Vagina Vagina Neoplasm Vaginal Tumor Vaginal Carcinoma Vaginal Malignant Epithelial Tumor Vaginal Neoplasm Malignant Vaginal Neoplasm Vagina Carcinoma Vaginal Neoplasia Cancer Of Vagina Malignant Tumour Of Vagina Carcinoma Of Vagina Primary Malignant Neoplasm Of Vagina Vagina Wall Cancer Vaginal Wall Cancer
Cervical Clear Cell Adenocarcinoma	Clear Cell Carcinoma Of The Cervix Uteri
Anus Disease	Anal Fissure Ulcer Of Anus Anus Diseases Anal Disease Anal Fissure And Fistula Anal Ulcer Fissure In Ano Nontraumatic Tear Of Anus Solitary Anal Ulcer Abnormality Of The Anus Anal Disorders Ulcer Of Anus And Rectum Solitary Ulcer Of Anus Stercoral Ulcer Of Anus
Middle Ear Carcinoma	Carcinoma Of Middle Ear Carcinoma Of The Middle Ear
Thrombocytopenia	Low Platelet Count Low Platelets Decreased Platelets Platelet Dysfunction Nos
Verrucous Carcinoma	Verrucous Squamous Carcinoma Verrucous Squamous Cell Carcinoma Warty Carcinoma Carcinoma Verrucous Carcinoma, Verrucous
Cervicitis	Uterine Cervicitis Inflammation Of Cervix
Squamous Cell Papilloma	Papilloma Epidermoid Papilloma Papilloma, Squamous Cell
Vulva Squamous Cell Carcinoma	Squamous Cell Carcinoma Of Vulva Vulvar Squamous Cell Carcinoma Vulvar Epidermoid Carcinoma Squamous Cell Carcinoma Of The Vulva
Cervical Carcinosarcoma	Cervical Malignant Mixed Mesodermal Mullerian Tumor Cervical Malignant Mixed Mullerian Tumor Cervical Mixed Epithelial And Mesenchymal Neoplasm
Comedo Carcinoma	Comedocarcinoma High Grade Ductal Breast Carcinoma In Situ
Epidermodysplasia Verruciformis 1	Epidermodysplasia Verruciformis Epidermodysplasia Verruciformis, Susceptibility To, 1 Lutz-Lewandowsky Epidermodysplasia Verruciformis EV1 Lewandowsky-Lutz Syndrome Ev
Oropharynx Cancer	Oropharyngeal Cancer Oropharyngeal Carcinoma Malignant Neoplasm Of Oropharynx Malignant Oropharyngeal Tumor Malignant Tumor Of Oropharynx Malignant Tumour Of Mesopharynx Oropharyngeal Cancer, Adult Cancer Of The Oropharynx
Penile Disease	Penile Diseases
Adenocarcinoma In Situ
Male Reproductive Organ Benign Neoplasm
Hemophilia B	Christmas Disease Factor Ix Deficiency F9 Deficiency HEMB Plasma Thromboplastin Component Deficiency Congenital Factor Ix Deficiency Mild Hemophilia B Severe Hemophilia B Congenital Factor Ix Disorder Deficiency, Functional Factor Ix Hem B Mild Congenital F9 Deficiency Mild Congenital Factor Ix Deficiency Moderate Hemophilia B Moderate Congenital F9 Deficiency Moderate Congenital Factor Ix Deficiency Severe Congenital F9 Deficiency Severe Congenital Factor Ix Deficiency Bleeding Disorder In Hemophilia B Carriers Congenital F9 Deficiency Recessive X-Linked Hemophilia B
Human Papillomavirus Infectious Disease	Hpv Papillomavirus Infections Human Papilloma Virus Infection
Vulvar Disease	Vulvar Diseases Vulvar Disorders
Common Wart	Verruca Vulgaris Viral Warts Nos Filiform Warts Digitate Warts
Rectal Disease	Rectal Diseases Rectal Disorders
Phimosis	Tight Foreskin Tight Frenulum Congenital Phimosis
Cervix Carcinoma	Cancer Of Cervix Carcinoma Of Cervix Carcinoma Cervix Uteri Carcinoma Of The Cervix Uteri

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (10)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-110382	Cyclic-di-GMP disodium	Activator	98.78%	Unkown
HY-159788	PROTAC K-Ras Degrader-4	Degrader	99.01%	Unkown
HY-107780B	Cyclic-di-GMP diammonium	Activator	99.07%	Unkown
HY-P11146	SppIP	Inhibitor	98.99%	Unkown
HY-107780	Cyclic-di-GMP	Activator	98.18%	Unkown
HY-110382S	Cyclic-di-GMP-13C20,15N10 disodium	Activator	/	Unkown
HY-RS05610	GP5 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-107780A	Cyclic-di-GMP sodium	Activator	/	Unkown
HY-RS17795	Gp5 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24263	Gp5 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	GP5	MGD	MGI:1096363
Bos taurus	GP5	VGNC	VGNC:29506
Rattus norvegicus	GP5	RGD	RGD:2724
Macaca mulatta	GP5	VGNC	VGNC:110362
Felis catus	GP5	VGNC	VGNC:102750
Others	GP5	NCBI