CDH20 - cadherin 20 Gene

Also Known as Cdh7; CDH7L3

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 28316

About CDH20

Cytogenetic location: 18q21.33 Genomic coordinates (GRCh38): 18:61,333,430-61,555,779 (from NCBI)

This gene has 4 transcripts (splice variants), 211 orthologues and 33 paralogues. Biased expression in brain (RPKM 10.7) and fat (RPKM 4.1).

Summary

This gene is a type II classical Cadherin from the Cadherin superfamily and one of three Cadherin 7-like genes located in a cluster on chromosome 18. The encoded membrane protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular Cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Type II (atypical) Cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I Cadherins. Since disturbance of intracellular adhesion is a prerequisite for invasion and metastasis of tumor cells, Cadherins are considered prime candidates for tumor suppressor genes. [provided by RefSeq, Jul 2008]

CDH20 Products (1)

mRNA Protein Name
NM_031891.4 NP_114097.2 cadherin-20 preproprotein

CDH20 Protein Structure

Cadherin

Cadherin: Cadherin domain (68 - 156)

Cadherin

Cadherin: Cadherin domain (170 - 264)

Cadherin

Cadherin: Cadherin domain (279 - 380)

Cadherin

Cadherin: Cadherin domain (394 - 485)

Cadherin

Cadherin: Cadherin domain (498 - 595)

Cadherin_C

Cadherin_C: Cadherin cytoplasmic region (644 - 793)

  • 0
  • 200
  • 400
  • 600
  • 801 a.a.
Protein Preferred Names Protein Names

cadherin-20

  • cadherin 20, type 2

Related Diseases

Diseases Alias
Craniofacial-Deafness-Hand Syndrome

  • CDHS

  • Craniofacial Deafness Hand Syndrome

  • Sommer-Young-Wee-Frye Syndrome

  • Features Of Flat Facial Profile, Hypertelorism, Hypoplastic Nose With Slitlike Nares, And A Sensorineural Hearing Loss

  • Craniofacial-Hearing Loss-Hand Syndrome
Choanal Atresia, Posterior

  • Choanal Atresia

  • Atresia Of Nares

  • Posterior Choanal Atresia

  • PCA

  • Imperforate Nares

  • Choanal Fusion

  • Congenital Stenosis Of Nares

  • Congenital Stenosis Of Choanae

  • Nasal Atresia Nos
Charge Syndrome

  • Charge Association

  • Hall-Hittner Syndrome

  • Charge Association--Coloboma, Heart Anomaly, Choanal Atresia, Retardation, Genital And Ear Anomalies

  • Hhs

  • Coloboma, Heart Anomaly, Choanal Atresia, Restriction Of Growth And Development, Genital And Ear Anomalies

  • Coloboma-Heart Defects-Atresia Choanae-Retardation Of Growth And Development-Genitourinary Problems-Ear Abnormalities Syndrome

  • CHARGES
Coloboma Of Macula

  • Coloboma

  • Congenital Ocular Coloboma

  • Microphthalmia, Isolated, With Coloboma

  • Agenesis Of Macula

  • Hereditary Macular Coloboma

  • Ocular Coloboma

  • Coloboma Of Eye

  • Macular Coloboma

  • Uveoretinal Coloboma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Canis familiaris CDH20 VGNC VGNC:39029
Rattus norvegicus CDH20 RGD RGD:1305438
Bos taurus CDH20 VGNC VGNC:27099
Felis catus CDH20 VGNC VGNC:60679
Macaca mulatta CDH20 VGNC VGNC:70970
Mus musculus CDH20 MGD MGI:1346069
Others CDH20 NCBI