GPR22 - G protein-coupled receptor 22 Gene

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 2845

About GPR22

Cytogenetic location: 7q22.3 Genomic coordinates (GRCh38): 7:107,470,057-107,477,845 (from NCBI)

This gene has 3 transcripts (splice variants), 1 gene allele, 226 orthologues and 16 paralogues. Biased expression in heart (RPKM 6.9), brain (RPKM 4.8) and 2 other tissues.

Summary

This gene is a member of the G-protein coupled receptor 1 family and encodes a multi-pass membrane protein. [provided by RefSeq, Jul 2008]

GPR22 Products (1)

mRNA	Protein	Name
NM_005295.3	NP_005286.2	G-protein coupled receptor 22

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables G protein-coupled receptor activity	IMP IMP: Inferred from mutant phenotype	18539757	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GPR22 Protein Structure

7tm_1

0
100
200
300
400
433 a.a.

Protein Preferred Names	Protein Names
G-protein coupled receptor 22	probable G-protein coupled receptor 22

Related Diseases

Diseases	Alias
Mitochondrial Myopathy, Encephalopathy, Lactic Acidosis, And Stroke-Like Episodes	Melas Syndrome MELAS Mitochondrial Encephalomyopathy Lactic Acidosis And Stroke-Like Episodes Mitochondrial Myopathy, Lactic Acidosis, Stroke-Like Episode Mitochondrial Encephalomyopathy, Lactic Acidosis, And Stroke-Like Episodes Myopathy, Mitochondrial-Encephalopathy-Lactic Acidosis-Stroke Mitochondrial Encephalomyopathy, Lactic Acidosis And Stroke-Like Episodes Mitochondrial Encephalopathy, Lactic Acidosis, And Stroke-Like Episodes Mitochondrial Myopathy, Encephalopathy, Lactic Acidosis And Stroke-Like Episodes Mitochondrial Encephalomyopathy With Lactic Acidosis And Stroke-Like Episodes Syndrome Myopathy, Mitochondrial, Encephalopathy, Lactic Acidosis, And Stroke-Like Episodes

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05696	GPR22 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20940	Gpr22 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27457	Gpr22 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	GPR22	RGD	RGD:1310848
Macaca mulatta	GPR22	VGNC	VGNC:73129
Canis familiaris	GPR22	VGNC	VGNC:41426
Mus musculus	GPR22	MGD	MGI:1920260
Felis catus	GPR22	VGNC	VGNC:67421
Bos taurus	GPR22	VGNC	VGNC:29580
Others	GPR22	NCBI