Tcof1 - treacle ribosome biogenesis factor 1 Gene

Rattus norvegicus

Gene ID: 291571 | Gene type: protein coding

About Tcof1

Summary

Predicted to enable protein heterodimerization activity; protein-macromolecule adaptor activity; and scaffold protein binding activity. Predicted to be involved in mesenchymal cell differentiation; nucleolar large rRNA transcription by RNA polymerase I; and regulation of translation. Predicted to be located in cytosol; fibrillar center; and nucleoplasm. Predicted to be active in nucleolus. Human ortholog(s) of this gene implicated in Treacher Collins syndrome and Treacher Collins syndrome 1. Orthologous to human TCOF1 (treacle ribosome biogenesis factor 1). [provided by Alliance of Genome Resources, Apr 2022]

Tcof1 Products(1)

mRNA	Protein	Name
NM_001395127.1	NP_001382056.1	treacle protein

Protein Preferred Names

Protein Names

treacle protein

Treacher Collins-Franceschetti syndrome 1 homolog

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-145269	AL-GDa62	Inhibitor	/	Unkown
HY-RS14320	TCOF1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Tcof1	NCBI	NCBI:6949

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