Kars1 - lysyl-tRNA synthetase 1 Gene

Rattus norvegicus

Also known as Kars; LysRS

Gene ID: 292028 | Gene type: protein coding

About Kars1

Summary

Enables several functions, including ATP binding activity; lysine-tRNA Ligase activity; and tRNA binding activity. Involved in several processes, including ERK1 and ERK2 cascade; diadenosine tetraphosphate biosynthetic process; and lysyl-tRNA aminoacylation. Located in cytosol and nucleus. Part of Aminoacyl-tRNA Synthetase multienzyme complex. Biomarker of sciatic neuropathy. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease recessive intermediate B and autosomal recessive nonsyndromic deafness 89. Orthologous to human KARS1 (lysyl-tRNA synthetase 1). [provided by Alliance of Genome Resources, Apr 2022]

Kars1 Products(2)

mRNA	Protein	Name
NM_001006967.2	NP_001006968.1	lysine--tRNA ligase isoform 1
NM_001399193.1	NP_001386122.1	lysine--tRNA ligase isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables ATP binding	IDA IDA: Inferred from direct assay	3988754	RGD
enables amino acid binding	IDA IDA: Inferred from direct assay	3988754	RGD
enables lysine-tRNA ligase activity	IDA IDA: Inferred from direct assay	6315704	RGD
enables tRNA binding	IDA IDA: Inferred from direct assay	7082655	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in ERK1 and ERK2 cascade	IMP IMP: Inferred from mutant phenotype	19524539	RGD
involved in basophil activation involved in immune response	IMP IMP: Inferred from mutant phenotype	19524539	RGD
involved in diadenosine tetraphosphate biosynthetic process	IDA IDA: Inferred from direct assay	3988754	RGD
involved in diadenosine tetraphosphate biosynthetic process	IMP IMP: Inferred from mutant phenotype	19524539	RGD
involved in lysyl-tRNA aminoacylation	IDA IDA: Inferred from direct assay	6315704	RGD
involved in positive regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	19524539	RGD
involved in response to X-ray	IDA IDA: Inferred from direct assay	4001316	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
part of aminoacyl-tRNA synthetase multienzyme complex	IDA IDA: Inferred from direct assay	3988754	RGD
located in cytoplasm	IDA IDA: Inferred from direct assay	19524539	RGD
located in nucleus	IDA IDA: Inferred from direct assay	19524539	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

lysine--tRNA ligase

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07071	KARS1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P991156	Rapaprutug	Ligand	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Kars1	NCBI	NCBI:3735

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