Kars1 - lysyl-tRNA synthetase 1 Gene

Also Known as Kars; LysRS

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 292028

Summary

Enables several functions, including ATP binding activity; lysine-tRNA Ligase activity; and tRNA binding activity. Involved in several processes, including ERK1 and ERK2 cascade; diadenosine tetraphosphate biosynthetic process; and lysyl-tRNA aminoacylation. Located in cytosol and nucleus. Part of Aminoacyl-tRNA Synthetase multienzyme complex. Biomarker of sciatic neuropathy. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease recessive intermediate B and autosomal recessive nonsyndromic deafness 89. Orthologous to human KARS1 (lysyl-tRNA synthetase 1). [provided by Alliance of Genome Resources, Apr 2022]

Kars1 Products (2)

mRNA Protein Name
NM_001006967.2 NP_001006968.1 lysine--tRNA ligase isoform 1
NM_001399193.1 NP_001386122.1 lysine--tRNA ligase isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables ATP binding IDA
IDA: Inferred from direct assay
3988754 RGD
enables amino acid binding IDA
IDA: Inferred from direct assay
3988754 RGD
enables lysine-tRNA ligase activity IDA
IDA: Inferred from direct assay
6315704 RGD
enables tRNA binding IDA
IDA: Inferred from direct assay
7082655 RGD
Biological Process GO Annotation Evidence References Source
involved in ERK1 and ERK2 cascade IMP
IMP: Inferred from mutant phenotype
19524539 RGD
involved in basophil activation involved in immune response IMP
IMP: Inferred from mutant phenotype
19524539 RGD
involved in diadenosine tetraphosphate biosynthetic process IDA
IDA: Inferred from direct assay
3988754 RGD
involved in diadenosine tetraphosphate biosynthetic process IMP
IMP: Inferred from mutant phenotype
19524539 RGD
involved in lysyl-tRNA aminoacylation IDA
IDA: Inferred from direct assay
6315704 RGD
involved in positive regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
19524539 RGD
involved in response to X-ray IDA
IDA: Inferred from direct assay
4001316 RGD
Cellular Component GO Annotation Evidence References Source
part of aminoacyl-tRNA synthetase multienzyme complex IDA
IDA: Inferred from direct assay
3988754 RGD
located in cytoplasm IDA
IDA: Inferred from direct assay
19524539 RGD
located in nucleus IDA
IDA: Inferred from direct assay
19524539 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

lysine--tRNA ligase

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07071 KARS1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
Bioactive MoleculesInhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P991156 Rapaprutug Ligand / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Kars1 NCBI NCBI:3735