2. Gene
  3. Casq2 - calsequestrin 2 Gene

Casq2 - calsequestrin 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as cardCSQ

Gene ID: 29209 | Gene type: protein coding

About Casq2

Summary

Enables protein homodimerization activity and protein kinase C binding activity. Involved in negative regulation of ryanodine-sensitive calcium-release channel activity; regulation of cardiac muscle cell contraction; and regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion. Located in Z disc and sarcoplasmic reticulum. Biomarker of congestive heart failure and supravalvular aortic stenosis. Human ortholog(s) of this gene implicated in catecholaminergic polymorphic ventricular tachycardia 2. Orthologous to human CASQ2 (calsequestrin 2). [provided by Alliance of Genome Resources, Apr 2022]

Casq2 Products(1)

mRNA Protein Name
NM_017131.2 NP_058827.3 calsequestrin-2 precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein homodimerization activity IDA
IDA: Inferred from direct assay
20353949 RGD
enables protein kinase C binding IDA
IDA: Inferred from direct assay
10431815 RGD
Biological Process GO Annotation Evidence Reference Source
involved in negative regulation of ryanodine-sensitive calcium-release channel activity IMP
IMP: Inferred from mutant phenotype
17569730 RGD
involved in regulation of cardiac muscle cell contraction IMP
IMP: Inferred from mutant phenotype
17569730 RGD
involved in regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion IMP
IMP: Inferred from mutant phenotype
17569730 RGD
Cellular Component GO Annotation Evidence Reference Source
located in Z disc IDA
IDA: Inferred from direct assay
11053140 RGD
located in sarcoplasmic reticulum IDA
IDA: Inferred from direct assay
17569730 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

calsequestrin-2

SR calcium binding protein

calsequestrin 2 (cardiac muscle)

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS01973 CASQ2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Casq2 NCBI NCBI:845