Efemp2 - EGF containing fibulin extracellular matrix protein 2 Gene

Predicted to enable heparin binding activity and protein homodimerization activity. Predicted to be involved in several processes, including negative regulation of vascular associated smooth muscle cell proliferation; positive regulation of aortic smooth muscle cell differentiation; and vasculature development. Predicted to act upstream of or within artery development and elastic fiber assembly. Predicted to be located in basement membrane; elastic fiber; and microfibril. Biomarker of osteoarthritis. Human ortholog(s) of this gene implicated in aortic aneurysm; arterial tortuosity syndrome; autosomal recessive cutis laxa type IB; endometrial cancer; and osteosarcoma. Orthologous to human EFEMP2 (EGF containing fibulin extracellular matrix protein 2). [provided by Alliance of Genome Resources, Apr 2022]