Fxyd2 - FXYD domain-containing ion transport regulator 2 Gene

Also Known as ATP1C; Atp1g1; GNAKATP

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 29639

Summary

This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved Amino acids. This gene, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. Related gene family members have been shown to induce channel activity in experimental expression systems. Transmembrane topology has been established for two family members, with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. The Type III integral membrane protein encoded by this gene is the gamma subunit of the Na,K-ATPase present on the plasma membrane. Although the Na,K-ATPase does not depend on the gamma subunit to be functional, it is thought that the gamma subunit modulates the enzyme's activity by inducing ion channel activity. Two transcript variants have been described for this gene that encode distinct isoforms. [provided by RefSeq, Jan 2010]

Fxyd2 Products (4)

mRNA Protein Name
NM_017349.3 NP_059045.2 sodium/potassium-transporting ATPase subunit gamma isoform b
NM_145717.2 NP_663769.1 sodium/potassium-transporting ATPase subunit gamma isoform a
NM_017349.3 NP_059045.2 sodium/potassium-transporting ATPase subunit gamma isoform b
NM_145717.2 NP_663769.1 sodium/potassium-transporting ATPase subunit gamma isoform a

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
16373350 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular hyperosmotic salinity response IEP
IEP: Inferred from expression pattern
15280368 RGD
involved in inorganic cation transmembrane transport IDA
IDA: Inferred from direct assay
12626497 RGD
involved in negative regulation of P-type sodium:potassium-exchanging transporter activity IMP
IMP: Inferred from mutant phenotype
15280368 RGD
involved in negative regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
15280368 RGD
involved in regulation of P-type sodium:potassium-exchanging transporter activity IDA
IDA: Inferred from direct assay
11756431 RGD
Cellular Component GO Annotation Evidence References Source
located in basolateral plasma membrane IDA
IDA: Inferred from direct assay
16757733 RGD
part of sodium:potassium-exchanging ATPase complex IDA
IDA: Inferred from direct assay
12626497 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

sodium/potassium-transporting ATPase subunit gamma

  • ATPase, Na+/K+ transporting, gamma 1 polypeptide

  • FXTD domain-containing ion transport regulator 2

  • Na(+)/K(+) ATPase subunit gamma

  • gamma subunit of sodium potassium ATPase

  • sodium pump gamma chain

  • sodium/potassium-transporting ATPase gamma chain

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05166 FXYD2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Fxyd2 NCBI NCBI:486