Fxyd2 - FXYD domain-containing ion transport regulator 2 Gene

Rattus norvegicus

Also known as ATP1C; Atp1g1; GNAKATP

Gene ID: 29639 | Gene type: protein coding

About Fxyd2

Summary

This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved Amino acids. This gene, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. Related gene family members have been shown to induce channel activity in experimental expression systems. Transmembrane topology has been established for two family members, with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. The Type III integral membrane protein encoded by this gene is the gamma subunit of the Na,K-ATPase present on the plasma membrane. Although the Na,K-ATPase does not depend on the gamma subunit to be functional, it is thought that the gamma subunit modulates the enzyme's activity by inducing ion channel activity. Two transcript variants have been described for this gene that encode distinct isoforms. [provided by RefSeq, Jan 2010]

Fxyd2 Products(4)

mRNA	Protein	Name
NM_017349.3	NP_059045.2	sodium/potassium-transporting ATPase subunit gamma isoform b
NM_145717.2	NP_663769.1	sodium/potassium-transporting ATPase subunit gamma isoform a
NM_017349.3	NP_059045.2	sodium/potassium-transporting ATPase subunit gamma isoform b
NM_145717.2	NP_663769.1	sodium/potassium-transporting ATPase subunit gamma isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16373350	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular hyperosmotic salinity response	IEP IEP: Inferred from expression pattern	15280368	RGD
involved in inorganic cation transmembrane transport	IDA IDA: Inferred from direct assay	12626497	RGD
involved in negative regulation of P-type sodium:potassium-exchanging transporter activity	IMP IMP: Inferred from mutant phenotype	15280368	RGD
involved in negative regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	15280368	RGD
involved in regulation of P-type sodium:potassium-exchanging transporter activity	IDA IDA: Inferred from direct assay	11756431	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in basolateral plasma membrane	IDA IDA: Inferred from direct assay	16757733	RGD
part of sodium:potassium-exchanging ATPase complex	IDA IDA: Inferred from direct assay	12626497	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

sodium/potassium-transporting ATPase subunit gamma

ATPase, Na+/K+ transporting, gamma 1 polypeptide	FXTD domain-containing ion transport regulator 2
Na(+)/K(+) ATPase subunit gamma	gamma subunit of sodium potassium ATPase
sodium pump gamma chain	sodium/potassium-transporting ATPase gamma chain

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05166	FXYD2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Fxyd2	NCBI	NCBI:486

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