Kcnab1 - potassium voltage-gated channel subfamily A regulatory beta subunit 1 Gene

Also Known as KvBeta3

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 29737

Summary

Enables aldo-keto reductase (NADP) activity; Potassium Channel regulator activity; and transmembrane transporter binding activity. Involved in animal organ development; myoblast differentiation; and negative regulation of delayed rectifier Potassium Channel activity. Located in several cellular components, including dendrite; juxtaparanode region of axon; and perikaryon. Part of voltage-gated Potassium Channel complex. Biomarker of hypertension. Human ortholog(s) of this gene implicated in temporal lobe epilepsy. Orthologous to human KCNAB1 (potassium voltage-gated channel subfamily A regulatory beta subunit 1). [provided by Alliance of Genome Resources, Apr 2022]

Kcnab1 Products (1)

mRNA Protein Name
NM_017303.3 NP_058999.1 voltage-gated potassium channel subunit beta-1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables aldo-keto reductase (NADPH) activity IDA
IDA: Inferred from direct assay
18222921 RGD
enables potassium channel regulator activity IDA
IDA: Inferred from direct assay
8183366 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
10585425 RGD
enables transmembrane transporter binding IPI
IPI: Inferred from physical interaction
8756417 RGD
Biological Process GO Annotation Evidence References Source
involved in diaphragm development IEP
IEP: Inferred from expression pattern
12652645 RGD
involved in heart development IEP
IEP: Inferred from expression pattern
12652645 RGD
involved in myoblast differentiation IEP
IEP: Inferred from expression pattern
12652645 RGD
involved in negative regulation of delayed rectifier potassium channel activity IDA
IDA: Inferred from direct assay
8183366 RGD
involved in negative regulation of delayed rectifier potassium channel activity IMP
IMP: Inferred from mutant phenotype
8799886 RGD
involved in regulation of delayed rectifier potassium channel activity IDA
IDA: Inferred from direct assay
8183366 RGD
involved in skeletal muscle tissue development IEP
IEP: Inferred from expression pattern
12652645 RGD
Cellular Component GO Annotation Evidence References Source
located in axon IDA
IDA: Inferred from direct assay
8756417 RGD
located in dendrite cytoplasm IDA
IDA: Inferred from direct assay
8756417 RGD
located in juxtaparanode region of axon IDA
IDA: Inferred from direct assay
8756417 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
8756417 RGD
located in perikaryon IDA
IDA: Inferred from direct assay
8756417 RGD
part of potassium channel complex IDA
IDA: Inferred from direct assay
9334400 RGD
located in proximal dendrite IDA
IDA: Inferred from direct assay
8756417 RGD
part of voltage-gated potassium channel complex IDA
IDA: Inferred from direct assay
8756417 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

voltage-gated potassium channel subunit beta-1

  • K(+) channel subunit beta-1

  • Kvbeta1.1

  • Kvbeta1.2

  • Kvbeta1.3

  • kv-beta-1

  • potassium channel, voltage gated subfamily A regulatory beta subunit 1

  • potassium channel, voltage-gated shaker related subfamily A regulatory beta subunit 1

  • potassium voltage-gated

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07103 KCNAB1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Kcnab1 NCBI NCBI:7881