Kcnab1 - potassium voltage-gated channel subfamily A regulatory beta subunit 1 Gene

Rattus norvegicus

Also known as KvBeta3

Gene ID: 29737 | Gene type: protein coding

About Kcnab1

Summary

Enables aldo-keto reductase (NADP) activity; Potassium Channel regulator activity; and transmembrane transporter binding activity. Involved in animal organ development; myoblast differentiation; and negative regulation of delayed rectifier Potassium Channel activity. Located in several cellular components, including dendrite; juxtaparanode region of axon; and perikaryon. Part of voltage-gated Potassium Channel complex. Biomarker of hypertension. Human ortholog(s) of this gene implicated in temporal lobe epilepsy. Orthologous to human KCNAB1 (potassium voltage-gated channel subfamily A regulatory beta subunit 1). [provided by Alliance of Genome Resources, Apr 2022]

Kcnab1 Products(1)

mRNA	Protein	Name
NM_017303.3	NP_058999.1	voltage-gated potassium channel subunit beta-1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables aldo-keto reductase (NADPH) activity	IDA IDA: Inferred from direct assay	18222921	RGD
enables potassium channel regulator activity	IDA IDA: Inferred from direct assay	8183366	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	10585425	RGD
enables transmembrane transporter binding	IPI IPI: Inferred from physical interaction	8756417	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in diaphragm development	IEP IEP: Inferred from expression pattern	12652645	RGD
involved in heart development	IEP IEP: Inferred from expression pattern	12652645	RGD
involved in myoblast differentiation	IEP IEP: Inferred from expression pattern	12652645	RGD
involved in negative regulation of delayed rectifier potassium channel activity	IDA IDA: Inferred from direct assay	8183366	RGD
involved in negative regulation of delayed rectifier potassium channel activity	IMP IMP: Inferred from mutant phenotype	8799886	RGD
involved in regulation of delayed rectifier potassium channel activity	IDA IDA: Inferred from direct assay	8183366	RGD
involved in skeletal muscle tissue development	IEP IEP: Inferred from expression pattern	12652645	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in axon	IDA IDA: Inferred from direct assay	8756417	RGD
located in dendrite cytoplasm	IDA IDA: Inferred from direct assay	8756417	RGD
located in juxtaparanode region of axon	IDA IDA: Inferred from direct assay	8756417	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	8756417	RGD
located in perikaryon	IDA IDA: Inferred from direct assay	8756417	RGD
part of potassium channel complex	IDA IDA: Inferred from direct assay	9334400	RGD
located in proximal dendrite	IDA IDA: Inferred from direct assay	8756417	RGD
part of voltage-gated potassium channel complex	IDA IDA: Inferred from direct assay	8756417	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

voltage-gated potassium channel subunit beta-1

K(+) channel subunit beta-1	Kvbeta1.1
Kvbeta1.2	Kvbeta1.3
kv-beta-1	potassium channel, voltage gated subfamily A regulatory beta subunit 1
potassium channel, voltage-gated shaker related subfamily A regulatory beta subunit 1	potassium voltage-gated

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07103	KCNAB1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Kcnab1	NCBI	NCBI:7881

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