Abca12 - ATP binding cassette subfamily A member 12 Gene

Predicted to enable ATPase-coupled transmembrane transporter activity; Apolipoprotein A-I receptor binding activity; and lipid transporter activity. Predicted to be involved in several processes, including corneocyte desquamation; phospholipid efflux; and positive regulation of intracellular lipid transport. Predicted to act upstream of or within several processes, including positive regulation of Cholesterol efflux; positive regulation of protein localization to cell surface; and skin development. Predicted to be located in bounding membrane of organelle; cytosol; and plasma membrane. Predicted to be active in intracellular membrane-bounded organelle. Human ortholog(s) of this gene implicated in autosomal recessive congenital ichthyosis 1; autosomal recessive congenital ichthyosis 4A; and autosomal recessive congenital ichthyosis 4B. Orthologous to human ABCA12 (ATP binding cassette subfamily A member 12). [provided by Alliance of Genome Resources, Apr 2022]