Mcph1 - microcephalin 1 Gene

Predicted to enable identical protein binding activity. Predicted to be involved in mitotic cell cycle and negative regulation of transcription by RNA polymerase II. Predicted to act upstream of or within several processes, including establishment of mitotic spindle orientation; neuronal stem cell population maintenance; and protein localization to centrosome. Predicted to be located in microtubule organizing center. Human ortholog(s) of this gene implicated in breast cancer; endometrial cancer; microcephaly; primary autosomal recessive microcephaly; and primary autosomal recessive microcephaly 1. Orthologous to human MCPH1 (microcephalin 1). [provided by Alliance of Genome Resources, Apr 2022]