2. Gene
  3. Diaph1 - diaphanous-related formin 1 Gene

Diaph1 - diaphanous-related formin 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as DRF1; Diap1; mDIA1

Gene ID: 307483 | Gene type: protein coding

About Diaph1

Summary

Predicted to enable several functions, including profilin binding activity; small GTPase binding activity; and transmembrane transporter binding activity. Involved in positive regulation of cell migration. Predicted to be located in several cellular components, including brush border; mitotic spindle; and ruffle membrane. Predicted to colocalize with spindle microtubule. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 1 and sensorineural hearing loss. Orthologous to human DIAPH1 (diaphanous related formin 1). [provided by Alliance of Genome Resources, Apr 2022]

Diaph1 Products(2)

mRNA Protein Name
NM_001107393.3 NP_001100863.3 protein diaphanous homolog 1 isoform 1
NM_001395102.1 NP_001382031.1 protein diaphanous homolog 1 isoform 2
Gene Ontology
  • Biological Process
Biological Process GO Annotation Evidence Reference Source
involved in positive regulation of cell migration IMP
IMP: Inferred from mutant phenotype
16943426 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

protein diaphanous homolog 1

diaphanous homolog 1

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-147329 RAGE 229 99.89% Unkown
HY-178926 RAGE406R Inhibitor / Unkown
HY-RS03763 DIAPH1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Diaph1 NCBI NCBI:1729