Cyfip1 - cytoplasmic FMR1 interacting protein 1 Gene

Rattus norvegicus

Gene ID: 308666 | Gene type: protein coding

About Cyfip1

Summary

Enables RNA 7-methylguanosine cap binding activity. Involved in several processes, including cellular response to Insulin stimulus; negative regulation of synaptic vesicle recycling; and positive regulation of cell projection organization. Located in several cellular components, including dendritic spine; distal axon; and filopodium tip. Biomarker of temporal lobe epilepsy. Human ortholog(s) of this gene implicated in autism spectrum disorder and schizophrenia. Orthologous to human CYFIP1 (cytoplasmic FMR1 interacting protein 1). [provided by Alliance of Genome Resources, Apr 2022]

Cyfip1 Products(1)

mRNA	Protein	Name
NM_001107517.1	NP_001100987.1	cytoplasmic FMR1-interacting protein 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables RNA 7-methylguanosine cap binding	IDA IDA: Inferred from direct assay	25453757	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to insulin stimulus	IMP IMP: Inferred from mutant phenotype	16260607	RGD
involved in negative regulation of synaptic vesicle recycling	IMP IMP: Inferred from mutant phenotype	26843638	RGD
involved in positive regulation of axon extension	IMP IMP: Inferred from mutant phenotype	16260607	RGD
involved in positive regulation of axonogenesis	IMP IMP: Inferred from mutant phenotype	16260607	RGD
involved in positive regulation of dendrite development	IMP IMP: Inferred from mutant phenotype	16260607	RGD
involved in positive regulation of ruffle assembly	IMP IMP: Inferred from mutant phenotype	16260607	RGD
involved in regulation of myelination	IMP IMP: Inferred from mutant phenotype	31371763	RGD
involved in response to electrical stimulus	IDA IDA: Inferred from direct assay	25453757	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in axonal growth cone	IDA IDA: Inferred from direct assay	16260607	RGD
located in central region of growth cone	IDA IDA: Inferred from direct assay	16260607	RGD
located in dendritic growth cone	IDA IDA: Inferred from direct assay	16260607	RGD
located in dendritic spine	IDA IDA: Inferred from direct assay	24667445	RGD
located in excitatory synapse	IDA IDA: Inferred from direct assay	24667445	RGD
located in filopodium tip	IDA IDA: Inferred from direct assay	16260607	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	16260607	RGD
located in peripheral region of growth cone	IDA IDA: Inferred from direct assay	16260607	RGD
located in terminal bouton	IDA IDA: Inferred from direct assay	26843638	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

cytoplasmic FMR1-interacting protein 1

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03430	CYFIP1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Cyfip1	NCBI	NCBI:23191

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