RGD1359108 - similar to RIKEN cDNA 3110043O21 Gene

Predicted to enable small GTPase binding activity. Predicted to contribute to guanyl-nucleotide exchange factor activity. Predicted to be involved in several processes, including negative regulation of GTP binding activity; regulation of organelle organization; and stress granule assembly. Predicted to be located in several cellular components, including Flemming body; axon; and cytoplasmic ribonucleoprotein granule. Predicted to be part of guanyl-nucleotide exchange factor complex. Predicted to be active in autophagosome and endosome. Human ortholog(s) of this gene implicated in frontotemporal dementia and/or amyotrophic lateral sclerosis-1. Orthologous to human C9orf72 (C9orf72-SMCR8 complex subunit). [provided by Alliance of Genome Resources, Apr 2022]