Ttll1 - tubulin tyrosine ligase-like 1 Gene

Mus musculus

Also known as 6330444E16Rik

Gene ID: 319953 | Gene type: protein coding

About Ttll1

Summary

Enables tubulin-glutamic acid Ligase activity. Acts upstream of or within several processes, including cerebellar Purkinje cell differentiation; mucociliary clearance; and protein polyglutamylation. Located in ciliary basal body. Used to study primary ciliary dyskinesia. Orthologous to human TTLL1 (tubulin tyrosine Ligase like 1). [provided by Alliance of Genome Resources, Apr 2022]

Ttll1 Products(2)

mRNA	Protein	Name
NM_001357953.1	NP_001344882.1	polyglutamylase complex subunit TTLL1
NM_178869.4	NP_849200.2	polyglutamylase complex subunit TTLL1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	17360631	MGI
enables tubulin-glutamic acid ligase activity	EXP EXP: Inferred from Experiment	15890843	MGI
enables tubulin-glutamic acid ligase activity	IDA IDA: Inferred from direct assay	30420556	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within axoneme assembly	IMP IMP: Inferred from mutant phenotype	20498047	MGI
acts upstream of or within cerebellar Purkinje cell differentiation	IGI IGI: Inferred from genetic interaction	30420556	MGI
acts upstream of or within epithelial cilium movement involved in extracellular fluid movement	IMP IMP: Inferred from mutant phenotype	20442420	MGI
acts upstream of or within flagellated sperm motility	IMP IMP: Inferred from mutant phenotype	20442420	MGI
acts upstream of or within immune response in nasopharyngeal-associated lymphoid tissue	IMP IMP: Inferred from mutant phenotype	29440671	MGI
acts upstream of or within mucociliary clearance	IMP IMP: Inferred from mutant phenotype	29440671	MGI
acts upstream of or within protein polyglutamylation	IDA IDA: Inferred from direct assay	29593216	MGI
acts upstream of or within protein polyglutamylation	IMP IMP: Inferred from mutant phenotype	20498047	MGI
acts upstream of or within regulation of blastocyst development	IMP IMP: Inferred from mutant phenotype	29593216	MGI
acts upstream of or within sperm axoneme assembly	IMP IMP: Inferred from mutant phenotype	20442420	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in ciliary basal body	IDA IDA: Inferred from direct assay	17499049	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

polyglutamylase complex subunit TTLL1

probable tubulin polyglutamylase TTLL1

PGs3	p49
tubulin polyglutamylase TTLL1	tubulin polyglutamylase complex subunit 3
tubulin--tyrosine ligase-like protein 1

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15228	TTLL1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ttll1	NCBI	NCBI:25809

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