Ttll1 - tubulin tyrosine ligase-like 1 Gene

Also Known as 6330444E16Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 319953

Summary

Enables tubulin-glutamic acid Ligase activity. Acts upstream of or within several processes, including cerebellar Purkinje cell differentiation; mucociliary clearance; and protein polyglutamylation. Located in ciliary basal body. Used to study primary ciliary dyskinesia. Orthologous to human TTLL1 (tubulin tyrosine Ligase like 1). [provided by Alliance of Genome Resources, Apr 2022]

Ttll1 Products (2)

mRNA Protein Name
NM_001357953.1 NP_001344882.1 polyglutamylase complex subunit TTLL1
NM_178869.4 NP_849200.2 polyglutamylase complex subunit TTLL1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
17360631 MGI
enables tubulin-glutamic acid ligase activity EXP
EXP: Inferred from Experiment
15890843 MGI
enables tubulin-glutamic acid ligase activity IDA
IDA: Inferred from direct assay
30420556 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within axoneme assembly IMP
IMP: Inferred from mutant phenotype
20498047 MGI
acts upstream of or within cerebellar Purkinje cell differentiation IGI
IGI: Inferred from genetic interaction
30420556 MGI
acts upstream of or within epithelial cilium movement involved in extracellular fluid movement IMP
IMP: Inferred from mutant phenotype
20442420 MGI
acts upstream of or within flagellated sperm motility IMP
IMP: Inferred from mutant phenotype
20442420 MGI
acts upstream of or within immune response in nasopharyngeal-associated lymphoid tissue IMP
IMP: Inferred from mutant phenotype
29440671 MGI
acts upstream of or within mucociliary clearance IMP
IMP: Inferred from mutant phenotype
29440671 MGI
acts upstream of or within protein polyglutamylation IDA
IDA: Inferred from direct assay
29593216 MGI
acts upstream of or within protein polyglutamylation IMP
IMP: Inferred from mutant phenotype
20498047 MGI
acts upstream of or within regulation of blastocyst development IMP
IMP: Inferred from mutant phenotype
29593216 MGI
acts upstream of or within sperm axoneme assembly IMP
IMP: Inferred from mutant phenotype
20442420 MGI
Cellular Component GO Annotation Evidence References Source
located in ciliary basal body IDA
IDA: Inferred from direct assay
17499049 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

polyglutamylase complex subunit TTLL1

probable tubulin polyglutamylase TTLL1

  • PGs3

  • p49

  • tubulin polyglutamylase TTLL1

  • tubulin polyglutamylase complex subunit 3

  • tubulin--tyrosine ligase-like protein 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15228 TTLL1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ttll1 NCBI NCBI:25809