Mical2 - microtubule associated monooxygenase, calponin and LIM domain containing 2 Gene

Also Known as MICAL-2; Micalcl; mKIAA0750; 9530064J02; 4921517J23Rik; 5330438E18Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 320878

Summary

Enables several functions, including NAD(P)H oxidase H2O2-forming activity; actin binding activity; and mitogen-activated protein kinase binding activity. Involved in actin filament depolymerization and sulfur oxidation. Located in cytoplasm. Is expressed in lower jaw molar and upper jaw molar. Orthologous to human MICAL2 (microtubule associated monooxygenase, calponin and LIM domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]

Mical2 Products (4)

mRNA Protein Name
NM_001193305.1 NP_001180234.1 [F-actin]-monooxygenase MICAL2 isoform A
NM_001381862.1 NP_001368791.1 [F-actin]-monooxygenase MICAL2 isoform D
NM_001395864.1 NP_001382793.1 [F-actin]-monooxygenase MICAL2 isoform C
NM_177282.5 NP_796256.1 [F-actin]-monooxygenase MICAL2 isoform B

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables NAD(P)H oxidase H2O2-forming activity IDA
IDA: Inferred from direct assay
23927065 MGI
enables actin binding IDA
IDA: Inferred from direct assay
23911929 MGI
enables mitogen-activated protein kinase binding IPI
IPI: Inferred from physical interaction
18241670 MGI
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen IDA
IDA: Inferred from direct assay
23911929 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
18590835 MGI
Biological Process GO Annotation Evidence References Source
involved in actin filament depolymerization IDA
IDA: Inferred from direct assay
23911929 MGI
involved in sulfur oxidation IDA
IDA: Inferred from direct assay
23911929 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
18241670 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

F-actin-monooxygenase MICAL2

[F-actin]-monooxygenase MICAL2

  • ERK2-binding testicular protein 1

  • MICAL C-terminal like

  • MICAL C-terminal-like protein

  • MICAL C-terminal-like protein-like

  • [F-actin]-methionine sulfoxide oxidase MICAL2

  • ebitein-1

  • ebitein1

  • mMical2

  • mical-cL

  • microtubule associated monoxygenase, calpon

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-P0107 RC-3095 Antagonist 99.43% Phase 2

Pre-clinical Phase

Bioactive Molecules (27)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P0107A RC-3095 TFA Antagonist 99.66% Unkown
HY-103316A Ned 19 Inhibitor 99.92% Unkown
HY-12736A GSK143 dihydrochloride Inhibitor 99.37% Unkown
HY-109506S DPPC-d62 99.0% Unkown
HY-145119S Mindeudesivir 98.20% Unkown
HY-W010516 2-Methylvaleric acid 99.98% Unkown
HY-W654264 2-Methylbutyrylcarnitine chloride Activator 98.92% Unkown
HY-N1393 2-Methoxybenzoic acid Inhibitor 99.86% Unkown
HY-75625 2-Hydroxy-4-methoxybenzoic acid 99.64% Unkown
HY-109506S1 DPPC-d9 98.0% Unkown
HY-109506S3 DPPC-d9-1 ≥99.0% Unkown
HY-109506S9 DPPC-13C2 95.0% Unkown
HY-131102 Mequindox Inhibitor 99.62% Unkown
HY-N1393R 2-Methoxybenzoic acid (Standard) / Unkown
HY-101139 Xanthine amine congener Antagonist / Unkown
HY-113902 (2-(β-Piperidinoethyl)-9-hydroxyellipticinium chloride Inhibitor / Unkown
HY-12736 GSK143 Inhibitor / Unkown
HY-162720 NNRT-IN-4 Inhibitor / Unkown
HY-B0448S1 Phenytoin-15N2,13C 99.84% Unkown
HY-D0195S Acesulfame-d4 potassium 99.72% Unkown
HY-N1393S1 2-Methoxybenzoic acid-d3 / Unkown
HY-RS08426 MICAL2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-109506S2 (Rac)-DPPC-d6 98.0% Unkown
HY-B0281AS Ranitidine-d6 hydrochloride Antagonist 97.00% Unkown
HY-N1393S 2-Methoxybenzoic acid-13C6 / Unkown
HY-RS20179 Mical2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26683 Mical2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mical2 NCBI NCBI:9645