HOXD1 - homeobox D1 Gene

Also Known as HOX4; HOX4G; Hox-4.7

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 3231

About HOXD1

Cytogenetic location: 2q31.1 Genomic coordinates (GRCh38): 2:176,188,668-176,190,907 (from NCBI)

This gene has 1 transcript (splice variant), 110 orthologues and 42 paralogues. Broad expression in kidney (RPKM 1.7), lung (RPKM 1.6) and 16 other tissues.

Summary

This gene is a member of the Antp homeobox family and encodes a protein with a homeobox DNA-binding domain. This nuclear protein functions as a sequence-specific transcription factor that is involved in differentiation and limb development. Mutations in this gene have been associated with severe developmental defects on the anterior-posterior (a-p) limb axis. [provided by RefSeq, Jul 2008]

HOXD1 Products (1)

mRNA Protein Name
NM_024501.3 NP_078777.1 homeobox protein Hox-D1

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables sequence-specific double-stranded DNA binding IDA
IDA: Inferred from direct assay
28473536 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HOXD1 Protein Structure

Homeobox

Homeobox: Homeobox domain (233 - 286)

  • 0
  • 100
  • 200
  • 300
  • 328 a.a.
Protein Preferred Names Protein Names

homeobox protein Hox-D1

  • homeo box 4G

Related Diseases

Diseases Alias
Synpolydactyly

  • Syndactyly Type 2

  • Syndactyly, Type 2

  • Spd
Clubfoot

  • Congenital Talipes Equinovarus

  • Congenital Clubfoot

  • Congenital Equinovarus

  • Equinovarus Deformity Of Foot

  • Club Foot
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06322 HOXD1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus HOXD1 MGD MGI:96201
Rattus norvegicus HOXD1 RGD RGD:1309179
Macaca mulatta HOXD1 VGNC VGNC:104536
Bos taurus HOXD1 VGNC VGNC:29929
Canis familiaris HOXD1 VGNC VGNC:41761
Felis catus HOXD1 VGNC VGNC:107557
Others HOXD1 NCBI