2. Gene
  3. Cngb1 - cyclic nucleotide gated channel beta 1 Gene

Cngb1 - cyclic nucleotide gated channel beta 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Garp2; Cngb1b; Gm1959

Gene ID: 333329 | Gene type: protein coding

About Cngb1

Summary

Enables cyclic nucleotide-gated ion channel activity. Involved in several processes, including detection of chemical stimulus involved in sensory perception of smell; ion channel modulating, G protein-coupled receptor signaling pathway; and response to odorant. Acts upstream of or within several processes, including photoreceptor cell maintenance; photoreceptor cell outer segment organization; and sensory perception of smell. Located in membrane and photoreceptor outer segment. Is expressed in several structures, including head mesenchyme; incisor; limb; sensory organ; and skeleton. Used to study retinitis pigmentosa. Human ortholog(s) of this gene implicated in retinitis pigmentosa and retinitis pigmentosa 45. Orthologous to human CNGB1 (cyclic nucleotide gated channel subunit beta 1). [provided by Alliance of Genome Resources, Apr 2022]

Cngb1 Products(2)

mRNA Protein Name
NM_001195413.1 NP_001182342.1 cyclic nucleotide-gated cation channel beta-1 isoform 1
NM_145601.1 NP_663576.1 cyclic nucleotide-gated cation channel beta-1 isoform 2
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables cyclic nucleotide-activated monoatomic ion channel activity IMP
IMP: Inferred from mutant phenotype
16980309 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within photoreceptor cell maintenance IMP
IMP: Inferred from mutant phenotype
15634774 MGI
acts upstream of or within photoreceptor cell outer segment organization IMP
IMP: Inferred from mutant phenotype
23178122 MGI
acts upstream of or within phototransduction IMP
IMP: Inferred from mutant phenotype
15634774 MGI
acts upstream of or within protein localization to organelle IMP
IMP: Inferred from mutant phenotype
16980309 MGI
acts upstream of or within sensory perception of smell IMP
IMP: Inferred from mutant phenotype
16980309 MGI
Cellular Component GO Annotation Evidence Reference Source
located in membrane IDA
IDA: Inferred from direct assay
15634774 MGI
located in photoreceptor outer segment IDA
IDA: Inferred from direct assay
22183407 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

cyclic nucleotide-gated cation channel beta-1

cyclic nucleotide-gated channel beta subunit 1

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS02883 CNGB1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cngb1 NCBI NCBI:1258