Fa2h - fatty acid 2-hydroxylase Gene

Mus musculus

Also known as FAAH; Faxdc1; G630055L08Rik

Gene ID: 338521 | Gene type: protein coding

About Fa2h

Summary

Enables fatty acid alpha-hydroxylase activity. Involved in galactosylceramide biosynthetic process; glucosylceramide biosynthetic process; and plasma membrane raft organization. Acts upstream of or within several processes, including lipid modification; myelin maintenance; and sebaceous gland cell differentiation. Located in endoplasmic reticulum. Is expressed in back skin; sebaceous gland; skin; and vibrissa. Used to study hereditary spastic paraplegia 35. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 35. Orthologous to human FA2H (fatty acid 2-hydroxylase). [provided by Alliance of Genome Resources, Apr 2022]

Fa2h Products(1)

mRNA	Protein	Name
NM_178086.3	NP_835187.2	fatty acid 2-hydroxylase

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables fatty acid 2-hydroxylase activity	IDA IDA: Inferred from direct assay	15658937	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within central nervous system myelin maintenance	IMP IMP: Inferred from mutant phenotype	18815260	MGI
involved in ceramide biosynthetic process	IMP IMP: Inferred from mutant phenotype	22517924	MGI
acts upstream of or within fatty acid metabolic process	IDA IDA: Inferred from direct assay	16998236	MGI
involved in galactosylceramide biosynthetic process	IDA IDA: Inferred from direct assay	15658937	MGI
involved in galactosylceramide biosynthetic process	IMP IMP: Inferred from mutant phenotype	18815260	MGI
involved in glucosylceramide biosynthetic process	IMP IMP: Inferred from mutant phenotype	21628453	MGI
acts upstream of or within lipid modification	IDA IDA: Inferred from direct assay	15658937	MGI
acts upstream of or within lipid modification	IMP IMP: Inferred from mutant phenotype	18815260	MGI
acts upstream of or within peripheral nervous system myelin maintenance	IMP IMP: Inferred from mutant phenotype	18815260	MGI
involved in plasma membrane raft organization	IMP IMP: Inferred from mutant phenotype	22517924	MGI
acts upstream of or within regulation of acinar cell proliferation	IMP IMP: Inferred from mutant phenotype	21628453	MGI
acts upstream of or within regulation of hair cycle	IMP IMP: Inferred from mutant phenotype	21628453	MGI
acts upstream of or within regulation of sebum secreting cell proliferation	IMP IMP: Inferred from mutant phenotype	21628453	MGI
acts upstream of or within sebaceous gland cell differentiation	IMP IMP: Inferred from mutant phenotype	21628453	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	15658937	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

fatty acid 2-hydroxylase

fatty acid alpha-hydroxylase

fatty acid hydroxylase domain containing 1

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04649	FA2H Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Fa2h	NCBI	NCBI:79152

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