Fa2h - fatty acid 2-hydroxylase Gene

Also Known as FAAH; Faxdc1; G630055L08Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 338521

Summary

Enables fatty acid alpha-hydroxylase activity. Involved in galactosylceramide biosynthetic process; glucosylceramide biosynthetic process; and plasma membrane raft organization. Acts upstream of or within several processes, including lipid modification; myelin maintenance; and sebaceous gland cell differentiation. Located in endoplasmic reticulum. Is expressed in back skin; sebaceous gland; skin; and vibrissa. Used to study hereditary spastic paraplegia 35. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 35. Orthologous to human FA2H (fatty acid 2-hydroxylase). [provided by Alliance of Genome Resources, Apr 2022]

Fa2h Products (1)

mRNA Protein Name
NM_178086.3 NP_835187.2 fatty acid 2-hydroxylase

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables fatty acid 2-hydroxylase activity IDA
IDA: Inferred from direct assay
15658937 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within central nervous system myelin maintenance IMP
IMP: Inferred from mutant phenotype
18815260 MGI
involved in ceramide biosynthetic process IMP
IMP: Inferred from mutant phenotype
22517924 MGI
acts upstream of or within fatty acid metabolic process IDA
IDA: Inferred from direct assay
16998236 MGI
involved in galactosylceramide biosynthetic process IDA
IDA: Inferred from direct assay
15658937 MGI
involved in galactosylceramide biosynthetic process IMP
IMP: Inferred from mutant phenotype
18815260 MGI
involved in glucosylceramide biosynthetic process IMP
IMP: Inferred from mutant phenotype
21628453 MGI
acts upstream of or within lipid modification IDA
IDA: Inferred from direct assay
15658937 MGI
acts upstream of or within lipid modification IMP
IMP: Inferred from mutant phenotype
18815260 MGI
acts upstream of or within peripheral nervous system myelin maintenance IMP
IMP: Inferred from mutant phenotype
18815260 MGI
involved in plasma membrane raft organization IMP
IMP: Inferred from mutant phenotype
22517924 MGI
acts upstream of or within regulation of acinar cell proliferation IMP
IMP: Inferred from mutant phenotype
21628453 MGI
acts upstream of or within regulation of hair cycle IMP
IMP: Inferred from mutant phenotype
21628453 MGI
acts upstream of or within regulation of sebum secreting cell proliferation IMP
IMP: Inferred from mutant phenotype
21628453 MGI
acts upstream of or within sebaceous gland cell differentiation IMP
IMP: Inferred from mutant phenotype
21628453 MGI
Cellular Component GO Annotation Evidence References Source
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
15658937 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

fatty acid 2-hydroxylase

  • fatty acid alpha-hydroxylase

  • fatty acid hydroxylase domain containing 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04649 FA2H Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Fa2h NCBI NCBI:79152