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POLN - DNA polymerase nu Gene

Also Known as POL4P

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 353497

About POLN

Cytogenetic location: 4p16.3 Genomic coordinates (GRCh38): 4:2,071,918-2,242,121 (from NCBI)

This gene has 13 transcripts (splice variants) and 160 orthologues. Broad expression in testis (RPKM 2.1), fat (RPKM 1.9) and 24 other tissues.

Summary

This gene encodes a DNA Polymerase type-A family member. The encoded protein plays a role in DNA repair and homologous recombination. This gene shares its 5' exons with some transcripts from overlapping GeneID: 79441, which encodes an augmentin-like protein complex subunit. [provided by RefSeq, Dec 2014]

POLN Products (1)

mRNA	Protein	Name
NM_181808.4	NP_861524.2	DNA polymerase nu

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA-directed DNA polymerase activity	IDA IDA: Inferred from direct assay	12794064	GOA
enables cyclin binding	IPI IPI: Inferred from physical interaction	19995904	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	19995904	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in double-strand break repair via homologous recombination	IMP IMP: Inferred from mutant phenotype	19995904	GOA
involved in interstrand cross-link repair	IMP IMP: Inferred from mutant phenotype	19908865	GOA
involved in translesion synthesis	IDA IDA: Inferred from direct assay	20102227	GOA
involved in translesion synthesis	IMP IMP: Inferred from mutant phenotype	19908865	GOA

Cellular Component GO Annotation	Evidence	References	Source
NOT located in nucleolus	IDA IDA: Inferred from direct assay	12794064	GOA
located in nucleus	IDA IDA: Inferred from direct assay	12794064	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

POLN Protein Structure

DNA_pol_A

0
200
400
600
800
900 a.a.

Protein Preferred Names	Protein Names
DNA polymerase nu	DNA polymerase N

Related Diseases

Diseases	Alias
Poland Syndrome	Poland Anomaly Poland Sequence Poland Syndactyly Poland'S Syndrome Poland'S Anomaly Poland'S Syndactyly Acro-Pectoro-Renal Field Defect Brachydactyly, Absent Pectoral Muscles And Agenesis/Hypoplasia Of Kidneys Unilateral Defect Of Pectoralis Muscle And Syndactyly Of The Hand Unilateral Defect Of Pectoralis Major And Syndactyly Of The Hand
Xeroderma Pigmentosum, Variant Type	Xeroderma Pigmentosum XPV Xeroderma Pigmentosum Variant Type Xeroderma Pigmentosum With Normal Dna Repair Rates Photosensitivity With Defective Dna Synthesis Xp De Sanctis-Cacchione Syndrome Desanctis-Cacchione Syndrome Xeroderma Pigmentosa Xerodermic Idiocy Xeroderma Pigmentosum Variant Xp - [Xeroderma Pigmentosum] Atrophoderma Pigmentosum
Hereditary Breast Ovarian Cancer Syndrome	Hereditary Breast And Ovarian Cancer Syndrome Brca1- And Brca2-Associated Hereditary Breast And Ovarian Cancer Breast And/Or Ovarian Cancer Breast And Ovarian Cancer Syndrome Hboc Syndrome Hereditary Breast And Ovarian Cancer Brca1- Brca2-Associated Hboc

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10835	POLN Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	POLN	VGNC	VGNC:44787
Macaca mulatta	POLN	VGNC	VGNC:76068
Mus musculus	POLN	MGD	MGI:2675617
Bos taurus	POLN	VGNC	VGNC:33129
Rattus norvegicus	POLN	RGD	RGD:7675413
Others	POLN	NCBI