Arpc5 - actin related protein 2/3 complex, subunit 5 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 360854

Summary

Predicted to enable actin filament binding activity. Predicted to be a structural constituent of Cytoskeleton. Involved in several processes, including actin filament network formation; orbitofrontal cortex development; and smooth muscle cell migration. Located in endosome and growth cone. Biomarker of congenital hypothyroidism. Orthologous to human ARPC5 (actin related protein 2/3 complex subunit 5). [provided by Alliance of Genome Resources, Apr 2022]

Arpc5 Products (1)

mRNA Protein Name
NM_001025717.1 NP_001020888.1 actin-related protein 2/3 complex subunit 5

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
involved in actin filament network formation IMP
IMP: Inferred from mutant phenotype
21281821 RGD
involved in lamellipodium organization IMP
IMP: Inferred from mutant phenotype
21281821 RGD
involved in maintenance of cell polarity IMP
IMP: Inferred from mutant phenotype
21281821 RGD
involved in microtubule organizing center localization IMP
IMP: Inferred from mutant phenotype
21281821 RGD
involved in orbitofrontal cortex development IEP
IEP: Inferred from expression pattern
23459330 RGD
involved in smooth muscle cell migration IMP
IMP: Inferred from mutant phenotype
21281821 RGD
Cellular Component GO Annotation Evidence References Source
located in endosome IDA
IDA: Inferred from direct assay
17959830 RGD
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
25293574 RGD
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
25293574 RGD
located in growth cone IDA
IDA: Inferred from direct assay
18256280 RGD
is active in postsynaptic density IDA
IDA: Inferred from direct assay
25293574 RGD
is active in postsynaptic density IMP
IMP: Inferred from mutant phenotype
25293574 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

actin-related protein 2/3 complex subunit 5

  • arp2/3 complex 16 kDa subunit

  • p16-ARC

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-145269 AL-GDa62 Inhibitor / Unkown
HY-RS01022 ARPC5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS01023 ARPC5L Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Arpc5 NCBI NCBI:10092