Parp4 - poly (ADP-ribose) polymerase family, member 4 Gene

Also Known as Adprtl1

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 361046

About Parp4

Primary_assembly 15: 30,686,613-30,828,810 forward strand.mRatBN7.2:CM026988.1

This gene has 5 transcripts (splice variants), 186 orthologues, 12 paralogues and is associated with 1 phenotype. Biased expression in Thymus (RPKM 164.7), Spleen (RPKM 138.1) and 9 other tissues.

Summary

Predicted to enable NAD+ ADP-ribosyltransferase activity; enzyme binding activity; and protein ADP-ribosylase activity. Predicted to be involved in several processes, including inflammatory response; protein mono-ADP-ribosylation; and regulation of Telomerase activity. Predicted to be located in cytosol and spindle microtubule. Orthologous to human PARP4 (poly(ADP-ribose) polymerase family member 4). [provided by Alliance of Genome Resources, Apr 2022]

Parp4 Products (2)

mRNA Protein Name
XM_039093848.1 XP_038949776.1 protein mono-ADP-ribosyltransferase PARP4 isoform X2
XM_039093847.1 XP_038949775.1 protein mono-ADP-ribosyltransferase PARP4 isoform X1

Parp4 Protein Structure

BRCT

BRCT: cl00038 (4 - 87)

parp_like

parp_like: cd01437 (259 - 572)

VIT

VIT: pfam08487 (631 - 741)

vWFA

vWFA: cl00057 (884 - 1053)

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  • 1500
  • 1806 a.a.
Protein Preferred Names Protein Names

poly [ADP-ribose] polymerase 4

protein mono-ADP-ribosyltransferase PARP4

  • ADP-ribosyltransferase (NAD+

  • ADP-ribosyltransferase (NAD+

  • poly (ADP-ribose) polymerase)-like 1

  • poly (ADP-ribose) polymerase)-like 1

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (4)
Cat. No. Nom du produit Effect
Pureté Rare Diseases
HY-10619 Niraparib Inhibitor 99.96% Yes
HY-10619A Niraparib hydrochloride Inhibitor 99.41% Yes
HY-10619B Niraparib tosylate Inhibitor 99.99% Yes
HY-10619E Niraparib tosylate hydrate Inhibitor 99.97% Yes

Clinical Phase

Bioactive Molecules (1)
Cat. No. Nom du produit Effect
Pureté Phase
HY-150207 RBN-3143 Inhibitor 99.29% Phase 1

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-136979 RBN012759 Inhibitor 99.33% Unkown
HY-148566 OUL232 Inhibitor 99.86% Unkown
HY-148754 PARP10-IN-3 Inhibitor 98.72% Unkown
HY-148753 PARP10-IN-2 Inhibitor 98.07% Unkown
HY-155993 YCH1899 Inhibitor 99.39% Unkown
HY-W294889 OUL245 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Parp4 NCBI NCBI:143