Rbfox2 - RNA binding fox-1 homolog 2 Gene

Rattus norvegicus

Also known as Rbm9

Gene ID: 362950 | Gene type: protein coding

About Rbfox2

Summary

Predicted to enable DNA-binding transcription factor binding activity; mRNA binding activity; and transcription corepressor activity. Predicted to be involved in several processes, including intracellular Estrogen receptor signaling pathway; regulation of RNA metabolic process; and regulation of definitive erythrocyte differentiation. Predicted to act upstream of or within several processes, including alternative mRNA splicing, via spliceosome; nervous system development; and regulation of heart rate by cardiac conduction. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in cytoplasm and nucleus. Orthologous to human RBFOX2 (RNA binding fox-1 homolog 2). [provided by Alliance of Genome Resources, Apr 2022]

Rbfox2 Products(1)

mRNA	Protein	Name
NM_001079895.1	NP_001073364.1	RNA binding protein fox-1 homolog 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables single-stranded RNA binding	IDA IDA: Inferred from direct assay	35641779	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to angiotensin	IEP IEP: Inferred from expression pattern	28993448	RGD
involved in cellular response to endothelin	IEP IEP: Inferred from expression pattern	28993448	RGD
involved in cellular response to hydrogen peroxide	IEP IEP: Inferred from expression pattern	35641779	RGD
involved in cellular response to retinoic acid	IEP IEP: Inferred from expression pattern	24151077	RGD
involved in heart development	IEP IEP: Inferred from expression pattern	24151077	RGD
involved in mRNA alternative polyadenylation	IMP IMP: Inferred from mutant phenotype	34731606	RGD
involved in negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	35641779	RGD
involved in negative regulation of membrane hyperpolarization	IMP IMP: Inferred from mutant phenotype	28993448	RGD
involved in negative regulation of mitochondrial depolarization	IMP IMP: Inferred from mutant phenotype	34731606	RGD
involved in positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	34731606	RGD
involved in positive regulation of vasoconstriction	IMP IMP: Inferred from mutant phenotype	28993448	RGD
involved in regulation of alternative mRNA splicing, via spliceosome	IMP IMP: Inferred from mutant phenotype	27239029	RGD
involved in regulation of mitochondrial gene expression	IMP IMP: Inferred from mutant phenotype	34731606	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	27485310	RGD
located in nucleus	IDA IDA: Inferred from direct assay	27485310	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

RNA binding protein fox-1 homolog 2

RNA binding protein, fox-1 homolog 2	RNA-binding motif protein 9
RNA-binding protein 9	RNA-binding protein FOX2
fox-1 homolog B

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11725	RBFOX2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Rbfox2	NCBI	NCBI:23543

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