Gnat1 - G protein subunit alpha transducin 1 Gene

Rattus norvegicus

Also known as Hg1f

Gene ID: 363143 | Gene type: protein coding

About Gnat1

Summary

Enables GTP binding activity. Involved in several processes, including detection of chemical stimulus involved in sensory perception of bitter taste; positive regulation of cyclic-nucleotide phosphodiesterase activity; and rhodopsin mediated signaling pathway. Located in several cellular components, including apical plasma membrane; photoreceptor inner segment; and photoreceptor outer segment. Part of heterotrimeric G-protein complex. Human ortholog(s) of this gene implicated in congenital stationary night blindness 1G; congenital stationary night blindness autosomal dominant 3; and night blindness. Orthologous to human GNAT1 (G protein subunit alpha transducin 1). [provided by Alliance of Genome Resources, Apr 2022]

Gnat1 Products(1)

mRNA	Protein	Name
NM_001108780.2	NP_001102250.2	guanine nucleotide-binding protein G(t) subunit alpha-1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables GTP binding	IDA IDA: Inferred from direct assay	7596440	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	18028335	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in G protein-coupled opsin signaling pathway	IMP IMP: Inferred from mutant phenotype	11931744	RGD
involved in detection of chemical stimulus involved in sensory perception of bitter taste	IDA IDA: Inferred from direct assay	7596440	RGD
involved in positive regulation of cyclic-nucleotide phosphodiesterase activity	IDA IDA: Inferred from direct assay	7878085	RGD
involved in response to light intensity	IDA IDA: Inferred from direct assay	11931744	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in apical plasma membrane	IDA IDA: Inferred from direct assay	17495045	RGD
part of heterotrimeric G-protein complex	IDA IDA: Inferred from direct assay	11931744	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	11931744	RGD
located in photoreceptor inner segment	IDA IDA: Inferred from direct assay	11931744	RGD
located in photoreceptor outer segment	IDA IDA: Inferred from direct assay	10396627	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

guanine nucleotide-binding protein G(t) subunit alpha-1

guanine nucleotide binding protein (G protein), alpha transducing 1	guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 1
guanine nucleotide binding protein, alpha transducing 1	heterotrimeric guanine nucleotide-bindi

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05541	GNAT1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Gnat1	NCBI	NCBI:2779

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