Chmp2b - charged multivesicular body protein 2B Gene

Rattus norvegicus

Also known as RGD1306781

Gene ID: 363720 | Gene type: protein coding

About Chmp2b

Summary

Predicted to enable protein domain specific binding activity. Involved in regulation of modification of postsynaptic structure and regulation of postsynapse organization. Is active in glutamatergic synapse and postsynaptic density. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis; chromosome 3-linked frontotemporal dementia; and frontotemporal dementia. Orthologous to human CHMP2B (charged multivesicular body protein 2B). [provided by Alliance of Genome Resources, Apr 2022]

Chmp2b Products(1)

mRNA	Protein	Name
NM_001398813.1	NP_001385742.1	charged multivesicular body protein 2b

Gene Ontology

Biological Process
Cellular Component

Biological Process GO Annotation	Evidence	Reference	Source
involved in modulation of chemical synaptic transmission	IDA IDA: Inferred from direct assay	25698751	RGD
involved in modulation of chemical synaptic transmission	IMP IMP: Inferred from mutant phenotype	25698751	RGD
involved in regulation of modification of postsynaptic structure	IDA IDA: Inferred from direct assay	25698751	RGD
involved in regulation of modification of postsynaptic structure	IMP IMP: Inferred from mutant phenotype	25698751	RGD
involved in regulation of postsynapse organization	IDA IDA: Inferred from direct assay	25698751	RGD
involved in regulation of postsynapse organization	IMP IMP: Inferred from mutant phenotype	25698751	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	25698751	RGD
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	25698751	RGD
is active in postsynaptic density	EXP EXP: Inferred from Experiment	25698751	RGD
is active in postsynaptic density	IDA IDA: Inferred from direct assay	25698751	RGD
is active in postsynaptic density	IMP IMP: Inferred from mutant phenotype	25698751	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

charged multivesicular body protein 2b

chromatin modifying protein 2B

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P10404	PDpep1.3	Antagonist	/	Unkown
HY-RS02641	CHMP2B Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Chmp2b	NCBI	NCBI:25978

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