Chmp2b - charged multivesicular body protein 2B Gene

Also Known as RGD1306781

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 363720

Summary

Predicted to enable protein domain specific binding activity. Involved in regulation of modification of postsynaptic structure and regulation of postsynapse organization. Is active in glutamatergic synapse and postsynaptic density. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis; chromosome 3-linked frontotemporal dementia; and frontotemporal dementia. Orthologous to human CHMP2B (charged multivesicular body protein 2B). [provided by Alliance of Genome Resources, Apr 2022]

Chmp2b Products (1)

mRNA Protein Name
NM_001398813.1 NP_001385742.1 charged multivesicular body protein 2b

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
involved in modulation of chemical synaptic transmission IDA
IDA: Inferred from direct assay
25698751 RGD
involved in modulation of chemical synaptic transmission IMP
IMP: Inferred from mutant phenotype
25698751 RGD
involved in regulation of modification of postsynaptic structure IDA
IDA: Inferred from direct assay
25698751 RGD
involved in regulation of modification of postsynaptic structure IMP
IMP: Inferred from mutant phenotype
25698751 RGD
involved in regulation of postsynapse organization IDA
IDA: Inferred from direct assay
25698751 RGD
involved in regulation of postsynapse organization IMP
IMP: Inferred from mutant phenotype
25698751 RGD
Cellular Component GO Annotation Evidence References Source
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
25698751 RGD
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
25698751 RGD
is active in postsynaptic density EXP
EXP: Inferred from Experiment
25698751 RGD
is active in postsynaptic density IDA
IDA: Inferred from direct assay
25698751 RGD
is active in postsynaptic density IMP
IMP: Inferred from mutant phenotype
25698751 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

charged multivesicular body protein 2b

  • chromatin modifying protein 2B

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P10404 PDpep1.3 Antagonist / Unkown
HY-RS02641 CHMP2B Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Chmp2b NCBI NCBI:25978