Phox2b - paired-like homeobox 2b Gene

Also Known as NBPhox

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 364152

Summary

Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in several processes, including nervous system development; positive regulation of cold-induced thermogenesis; and regulation of respiratory gaseous exchange by nervous system process. Predicted to act upstream of or within several processes, including nervous system development; regulation of neuron differentiation; and skeletal muscle cell differentiation. Located in nucleus. Human ortholog(s) of this gene implicated in congenital central hypoventilation syndrome. Orthologous to human PHOX2B (paired like homeobox 2B). [provided by Alliance of Genome Resources, Apr 2022]

Phox2b Products (1)

mRNA Protein Name
XM_008770167.3 XP_008768389.3 paired mesoderm homeobox protein 2B

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
involved in cellular response to carbon dioxide IEP
IEP: Inferred from expression pattern
19036978 RGD
involved in membrane depolarization IEP
IEP: Inferred from expression pattern
19036978 RGD
involved in response to activity IEP
IEP: Inferred from expression pattern
24286756 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

paired mesoderm homeobox protein 2B

  • neuroblastoma Phox

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10452 PHOX2B Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Phox2b NCBI NCBI:8929