Foxl2 - forkhead box L2 Gene

Predicted to enable several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; Estrogen receptor binding activity; and ubiquitin conjugating enzyme binding activity. Predicted to be involved in several processes, including apoptotic DNA fragmentation; extraocular skeletal muscle development; and positive regulation of cysteine-type endopeptidase activity involved in apoptotic process. Predicted to act upstream of or within several processes, including positive regulation of gonadotropin secretion; regulation of transcription by RNA polymerase II; and reproductive structure development. Predicted to be located in Flemming body and nucleoplasm. Human ortholog(s) of this gene implicated in blepharophimosis, ptosis, and epicanthus inversus syndrome and primary ovarian insufficiency 3. Orthologous to human FOXL2 (forkhead box L2). [provided by Alliance of Genome Resources, Apr 2022]