2. Gene
  3. Col27a1 - collagen, type XXVII, alpha 1 Gene

Col27a1 - collagen, type XXVII, alpha 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as 5730512J02Rik

Gene ID: 373864 | Gene type: protein coding

About Col27a1

Summary

This gene encodes the alpha-1 subunit of type XXVII Collagen, one of the low abundance fibril-forming collagens found in cartilage. The encoded protein forms a homotrimeric triple helical procollagen that undergoes proteolytic processing during fibril formation. Transgenic mice lacking a portion of the collagenous domain in the encoded protein exhibit skeletal abnormalities, chondrodysplasia and die at birth because of a lung defect. [provided by RefSeq, Dec 2015]

Col27a1 Products(1)

mRNA Protein Name
NM_025685.3 NP_079961.3 collagen alpha-1(XXVII) chain preproprotein
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables extracellular matrix structural constituent IDA
IDA: Inferred from direct assay
22206015 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within extracellular matrix organization IMP
IMP: Inferred from mutant phenotype
22206015 MGI
acts upstream of or within growth plate cartilage chondrocyte development IMP
IMP: Inferred from mutant phenotype
22206015 MGI
Cellular Component GO Annotation Evidence Reference Source
part of fibrillar collagen trimer IDA
IDA: Inferred from direct assay
17331945 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

collagen alpha-1(XXVII) chain

procollagen, type XXVII, alpha 1

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS02979 COL27A1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Col27a1 NCBI NCBI:85301