2. Gene
  3. Mir18 - microRNA 18 Gene

Mir18 - microRNA 18 Gene

  • Gene
  • Agent
Mus musculus

Also known as Mirn18; mir-18a; mmu-mir-18; mmu-mir-18a

Gene ID: 387135 | Gene type: ncRNA

About Mir18

Summary

MicroRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted MicroRNA stem-loop. [provided by RefSeq, Sep 2009]

Gene Ontology
  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within B cell apoptotic process IGI
IGI: Inferred from genetic interaction
18329372 MGI
acts upstream of or within cellular response to estrogen stimulus IDA
IDA: Inferred from direct assay
18791161 MGI
acts upstream of or within cellular response to forskolin IEP
IEP: Inferred from expression pattern
21993888 MGI
acts upstream of or within cellular response to leukemia inhibitory factor IEP
IEP: Inferred from expression pattern
20439489 MGI
acts upstream of gene expression IDA
IDA: Inferred from direct assay
23152446 MGI
acts upstream of gene expression IMP
IMP: Inferred from mutant phenotype
23152446 MGI
acts upstream of or within in utero embryonic development IGI
IGI: Inferred from genetic interaction
18329372 MGI
acts upstream of or within lung development IGI
IGI: Inferred from genetic interaction
18329372 MGI
acts upstream of or within negative regulation of apoptotic process IGI
IGI: Inferred from genetic interaction
18329372 MGI
acts upstream of or within negative regulation of gene expression IDA
IDA: Inferred from direct assay
23152446 MGI
acts upstream of or within positive regulation of gene expression IDA
IDA: Inferred from direct assay
23152446 MGI
acts upstream of or within positive regulation of gene expression IMP
IMP: Inferred from mutant phenotype
23152446 MGI
acts upstream of or within pre-B cell differentiation IGI
IGI: Inferred from genetic interaction
18329372 MGI
acts upstream of or within response to bacterium IEP
IEP: Inferred from expression pattern
24205035 MGI
acts upstream of or within spinal cord motor neuron differentiation IGI
IGI: Inferred from genetic interaction
21338882 MGI
acts upstream of or within ventricular septum morphogenesis IGI
IGI: Inferred from genetic interaction
18329372 MGI
Cellular Component GO Annotation Evidence Reference Source
located in axon IDA
IDA: Inferred from direct assay
17656374 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Related Agents

Pre-clinical Phase
Bioactive Molecules (32)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-R00353 hsa-miR-18a-5p mimic 92.48% Unkown
HY-RI00353 hsa-miR-18a-5p inhibitor 99.48% Unkown
HY-RI02722 mmu-miR-18a-3p inhibitor 94.40% Unkown
HY-R00352 hsa-miR-18a-3p mimic 93.58% Unkown
HY-R00352A hsa-miR-18a-3p agomir / Unkown
HY-R00353A hsa-miR-18a-5p agomir / Unkown
HY-R00354 hsa-miR-18b-3p mimic / Unkown
HY-R00354A hsa-miR-18b-3p agomir / Unkown
HY-R00355 hsa-miR-18b-5p mimic / Unkown
HY-R00355A hsa-miR-18b-5p agomir / Unkown
HY-R02722 mmu-miR-18a-3p mimic / Unkown
HY-R02722A mmu-miR-18a-3p agomir / Unkown
HY-R02723 mmu-miR-18b-3p mimic / Unkown
HY-R02723A mmu-miR-18b-3p agomir / Unkown
HY-R02724 mmu-miR-18b-5p mimic / Unkown
HY-R02724A mmu-miR-18b-5p agomir / Unkown
HY-R04263 rno-miR-18a-3p mimic / Unkown
HY-R04263A rno-miR-18a-3p agomir / Unkown
HY-RI00352 hsa-miR-18a-3p inhibitor / Unkown
HY-RI00352A hsa-miR-18a-3p antagomir / Unkown
HY-RI00353A hsa-miR-18a-5p antagomir / Unkown
HY-RI00354 hsa-miR-18b-3p inhibitor / Unkown
HY-RI00354A hsa-miR-18b-3p antagomir / Unkown
HY-RI00355 hsa-miR-18b-5p inhibitor / Unkown
HY-RI00355A hsa-miR-18b-5p antagomir / Unkown
HY-RI02722A mmu-miR-18a-3p antagomir / Unkown
HY-RI02723 mmu-miR-18b-3p inhibitor / Unkown
HY-RI02723A mmu-miR-18b-3p antagomir / Unkown
HY-RI02724 mmu-miR-18b-5p inhibitor / Unkown
HY-RI02724A mmu-miR-18b-5p antagomir / Unkown
HY-RI04263 rno-miR-18a-3p inhibitor / Unkown
HY-RI04263A rno-miR-18a-3p antagomir / Unkown