2. Gene
  3. Mir208a - microRNA 208a Gene

Mir208a - microRNA 208a Gene

  • Gene
  • Agent
  • Ortholog
Mus musculus

Also known as Mirn208; mir-208; Mirn208a; mir-208a; mmu-mir-208

Gene ID: 387204 | Gene type: ncRNA

About Mir208a

Summary

MicroRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted MicroRNA stem-loop. [provided by RefSeq, Sep 2009]

Gene Ontology
  • Biological Process
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within cardiac conduction IMP
IMP: Inferred from mutant phenotype
19726871 MGI
acts upstream of or within cardiac muscle cell development IMP
IMP: Inferred from mutant phenotype
17379774 MGI
acts upstream of or within cellular response to mechanical stimulus IMP
IMP: Inferred from mutant phenotype
17379774 MGI
acts upstream of or within heart growth IMP
IMP: Inferred from mutant phenotype
17379774 MGI
acts upstream of or within muscle cell development IMP
IMP: Inferred from mutant phenotype
19922871 MGI
acts upstream of or within regulation of gene expression IMP
IMP: Inferred from mutant phenotype
19726871 MGI
acts upstream of or within regulation of heart growth IDA
IDA: Inferred from direct assay
19726871 MGI
acts upstream of or within response to oxygen levels IDA
IDA: Inferred from direct assay
19188439 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Related Agents

Pre-clinical Phase
Bioactive Molecules (8)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-R00422 hsa-miR-208a-3p mimic 92.56% Unkown
HY-R00422A hsa-miR-208a-3p agomir / Unkown
HY-R04295 rno-miR-208a-3p mimic / Unkown
HY-R04295A rno-miR-208a-3p agomir / Unkown
HY-RI00422 hsa-miR-208a-3p inhibitor / Unkown
HY-RI00422A hsa-miR-208a-3p antagomir / Unkown
HY-RI04295 rno-miR-208a-3p inhibitor / Unkown
HY-RI04295A rno-miR-208a-3p antagomir / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mir208a NCBI NCBI:406990