MIR142 - microRNA 142 Gene
Also Known as MIRN142; mir-142
Species: Homo sapiens
About MIR142
This gene has 1 transcript (splice variant) and 142 orthologues.
Summary
MicroRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted MicroRNA stem-loop. [provided by RefSeq, Sep 2009]
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables mRNA 3'-UTR binding |
IDA
IDA: Inferred from direct assay
|
27277258 | GOA |
| enables mRNA base-pairing translational repressor activity |
IDA
IDA: Inferred from direct assay
|
22870299 | GOA |
| Cellular Component GO Annotation | Evidence | References | Source |
|---|---|---|---|
| located in extracellular space |
IDA
IDA: Inferred from direct assay
|
25203061 | GOA |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Brain Cancer |
|
|
| Multiple Sclerosis |
|
|
| Psoriasis |
|
|
| Endometriosis |
|
|
| Systemic Lupus Erythematosus |
|
|
| Squamous Cell Carcinoma, Head And Neck |
|
|
| Leukemia, Acute Myeloid |
|
|
| Ovarian Cancer |
|
|
| Systemic Scleroderma |
|
|
| Autoimmune Disease Of Central Nervous System |
|
|
| Hepatocellular Carcinoma |
|
|
| Oral Cavity Cancer |
|
|
| Retinitis Pigmentosa |
|
|
| Lichen Disease |
|
|
| Connective Tissue Cancer |
|
|
| Autoimmune Disease Of Musculoskeletal System |
|
|
| Immune System Disease |
|
|
| Bile Duct Adenocarcinoma |
|
|
| Lymphatic System Cancer |
|
|
| Lymphatic System Disease |
|
|
| Biliary Atresia |
|
|
| Respiratory System Cancer |
|
|
| Respiratory System Disease |
|
|
| Gastrointestinal System Disease |
|
|
| Upper Respiratory Tract Disease |
|
|
| Carbohydrate Metabolic Disorder |
|
|
| Integumentary System Disease |
|
|
| Bone Inflammation Disease |
|
|
| Lichen Planus |
|
|
| Urinary System Disease |
|
|
| Glucose Metabolism Disease |
|
|
| Nasopharyngeal Disease |
|
|
| Large Intestine Cancer |
|
|
| Inherited Metabolic Disorder |
|
|
| Colonic Disease |
|
|
| Gastrointestinal System Cancer |
|
|
| Intestinal Disease |
|
|
| Arteriosclerosis |
|
|
| Ovarian Disease |
|
|
| Bile Duct Cancer |
|
|
| Anterolateral Myocardial Infarction |
|
|
| Galloway-Mowat Syndrome 2 |
|
|
| Bile Duct Disease |
|
|
| Arteriosclerosis Obliterans |
|
|
| Endocrine System Disease |
|
|
| Larynx Cancer |
|
|
| Bronchial Disease |
|
|
| Leukocyte Disease |
|
|
| Reproductive System Disease |
|
|
| Female Reproductive System Disease |
|
|
| Central Nervous System Cancer |
|
|
| Stomach Disease |
|
|
| Spinal Disease |
|
|
| Pharynx Cancer |
|
|
| Male Reproductive Organ Cancer |
|
|
| Thoracic Cancer |
|
|
| Arteries, Anomalies Of |
|
|
| Cervix Disease |
|
|
| Biliary Tract Disease |
|
|
| Pleural Cancer |
|
|
| Male Reproductive System Disease |
|
|
| Secondary Progressive Multiple Sclerosis |
|
|
| Endocrine Gland Cancer |
|
|
| Sensory System Disease |
|
|
| Mature B-Cell Neoplasm |
|
|
| Atypical Teratoid Rhabdoid Tumor |
|
|
| Uterine Anomalies |
|
|
| Cell Type Benign Neoplasm |
|
|
| Periodontitis |
|
|
| Malignant Astrocytoma |
|
|
| Intrinsic Cardiomyopathy |
|
|
| Ureteral Disease |
|
|
| Malignant Exocrine Pancreas Neoplasm |
|
|
| Marginal Zone B-Cell Lymphoma |
|
|
| Pancreas Disease |
|
|
| Bone Marrow Cancer |
|
|
| Acquired Metabolic Disease |
|
|
| Autoimmune Disease Of Skin And Connective Tissue |
|
|
| Disease Of Mental Health |
|
|
| Fatty Liver Disease |
|
|
| Central Nervous System Disease |
|
|
| Pleural Disease |
|
|
| Autoimmune Disease Of Gastrointestinal Tract |
|
|
| Gastrointestinal System Benign Neoplasm |
|
|
| Granulomatosis With Polyangiitis |
|
|
| Spinal Cord Disease |
|
|
| Tongue Disease |
|
|
| Primary Progressive Multiple Sclerosis |
|
|
| Bone Resorption Disease |
|
|
| Laryngeal Disease |
|
|
| Overnutrition |
|
|
| Disease By Infectious Agent |
|
|
| Biliary Tract Cancer |
|
|
| Head And Neck Cancer |
|
|
| Intermediate Coronary Syndrome |
|
|
| Colorectal Adenoma |
|
|
| Lymphoma, Mucosa-Associated Lymphoid Type |
|
|
| Nasopharyngeal Carcinoma |
|
|
| Autoimmune Disease Of Endocrine System |
|
|
| Retinal Cancer |
|
|
| Bone Cancer |
|
|
| Bone Sarcoma |
|
|
| Bone Remodeling Disease |
|
|
| Retinitis Pigmentosa 60 |
|
|
| Liver Disease |
|
|
| Retinal Disease |
|
|
| Intestinal Benign Neoplasm |
|
|
| Prostate Disease |
|
|
| Autonomic Nervous System Neoplasm |
|
|
| Bladder Disease |
|
|
| Autoimmune Disease Of Exocrine System |
|
|
| Demyelinating Disease |
|
|
| Muscular Disease |
|
|
| Gallbladder Disease |
|
|
| Gastric Lymphoma |
|
|
| Breast Disease |
|
|
| Ocular Cancer |
|
|
| Renal Cell Carcinoma, Nonpapillary |
|
|
| Peripheral Nervous System Neoplasm |
|
|
| Lung Cancer |
|
|
| Lipid Storage Disease |
|
|
| Esophageal Disease |
|
|
| Myocardial Infarction |
|
|
| Muscle Tissue Disease |
|
|
| Hematologic Cancer |
|
|
| Colorectal Cancer |
|
|
| Tongue Squamous Cell Carcinoma |
|
|
| Relapsing-Remitting Multiple Sclerosis |
|
|
| Urinary Tract Obstruction |
|
|
| Prion Disease |
|
|
| Esophageal Cancer |
|
|
| Intrahepatic Cholangiocarcinoma |
|
|
| Chronic Fatigue Syndrome |
|
|
| Extrinsic Cardiomyopathy |
|
|
| Low Grade Glioma |
|
|
| Syphilis |
|
|
| Cervix Carcinoma |
|
|
| Pre-Malignant Neoplasm |
|
|
| Renal Fibrosis |
|
|
| Lymphoma, Non-Hodgkin, Familial |
|
|
| Focal Epilepsy |
|
|
| Uveal Disease |
|
|
| Connective Tissue Disease |
|
|
| Mouth Disease |
|
|
| Chromosomal Disease |
|
|
| Ovary Epithelial Cancer |
|
|
| Chromosomal Deletion Syndrome |
|
|
| Adult T-Cell Leukemia/Lymphoma |
|
|
| Central Nervous System Benign Neoplasm |
|
|
| Primary Bacterial Infectious Disease |
|
|
| Interstitial Lung Disease |
|
|
| Bone Disease |
|
|
| Peripheral Nervous System Disease |
|
|
| Crohn'S Disease |
|
|
| Pancreatic Ductal Adenocarcinoma |
|
|
| Cerebrovascular Disease |
|
|
| Mastitis |
|
|
| Infratentorial Cancer |
|
|
| Retinitis Pigmentosa 11 |
|
|
| Contact Dermatitis |
|
|
| Rectum Cancer |
|
|
| In Situ Carcinoma |
|
|
| Nervous System Disease |
|
|
| Toxic Encephalopathy |
|
|
| Kidney Cancer |
|
|
| Immune Deficiency Disease |
|
|
| Cardiovascular System Disease |
|
|
| Interstitial Lung Disease 2 |
|
|
| Gallbladder Cancer |
|
|
| Heart Conduction Disease |
|
|
| Blood Coagulation Disease |
|
|
| Human Papillomavirus Infectious Disease |
|
|
| Lysosomal Storage Disease |
|
|
| Allergic Contact Dermatitis |
|
|
| Oral Squamous Cell Carcinoma |
|
|
| Respiratory Allergy |
|
|
| Diffuse Large B-Cell Lymphoma |
|
|
| Eye Disease |
|
|
| Mild Cognitive Impairment |
|
|
| Heart Valve Disease |
|
|
| Physical Disorder |
|
|
| Aortic Disease |
|
|
| Thyroid Gland Disease |
|
|
| Wilms Tumor 1 |
|
|
| Hashimoto Thyroiditis |
|
|
| Non-Alcoholic Steatohepatitis |
|
|
| Pulmonary Disease, Chronic Obstructive |
|
|
| Pancreatic Cancer |
|
|
| Heart Disease |
|
|
| Mental Depression |
|
|
| Endocrine Organ Benign Neoplasm |
|
|
| Thymus Gland Disease |
|
|
| Skin Disease |
|
|
| Reproductive Organ Benign Neoplasm |
|
|
| High Grade Glioma |
|
|
| Thymus Cancer |
|
|
| Colorectal Adenocarcinoma |
|
|
| Parasitic Protozoa Infectious Disease |
|
|
| Gastric Cancer |
|
|
| Melanoma, Uveal |
|
|
| Eye Degenerative Disease |
|
|
| Leukemia, Chronic Lymphocytic |
|
|
| Plasma Cell Neoplasm |
|
|
| Blood Platelet Disease |
|
|
| Lung Cancer Susceptibility 3 |
|
|
| Motor Neuron Disease |
|
|
| Lipoprotein Quantitative Trait Locus |
|
|
| Leukemia, Chronic Myeloid |
|
|
| Respiratory Failure |
|
|
| Hypertrophic Cardiomyopathy |
|
|
| Leukemia, Acute Lymphoblastic |
|
|
| Dilated Cardiomyopathy |
|
|
| Body Mass Index Quantitative Trait Locus 11 |
|
|
| T-Cell Acute Lymphoblastic Leukemia |
|
|
| Amyotrophic Lateral Sclerosis 1 |
|
|
| Alzheimer Disease, Familial, 1 |
|
|
| Breast Cancer |
|
|
| Dermatitis, Atopic |
|
|
| Myeloma, Multiple |
|
|
| Primary Biliary Cholangitis |
|
|
| Myelodysplastic Syndrome |
|
|
| Parkinson Disease, Late-Onset |
|
|
| Type 2 Diabetes Mellitus |
|
|
| Myopathy |
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Mus musculus | MIR142 | MGD | MGI:2676827 |
| Rattus norvegicus | MIR142 | RGD | RGD:2325567 |