MIR149 - microRNA 149 Gene
Also Known as MIRN149; mir-149
Species: Homo sapiens
About MIR149
This gene has 1 transcript (splice variant).
Summary
MicroRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted MicroRNA stem-loop. [provided by RefSeq, Sep 2009]
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Pituitary Adenoma |
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| Follicular Lymphoma |
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| Diffuse Large B-Cell Lymphoma |
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| Eyelid Carcinoma |
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| Melanoma |
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| Glioblastoma |
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| Prostate Cancer |
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| Breast Cancer |
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| Corneal Dystrophy, Congenital Stromal |
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| Stomach Disease |
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| Larynx Cancer |
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| Oral Cavity Cancer |
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| Bladder Disease |
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| Large Intestine Cancer |
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| Stromal Dystrophy |
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| Gastrointestinal System Cancer |
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| Cervix Carcinoma |
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| Intestinal Disease |
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| Respiratory System Cancer |
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| Esophageal Disease |
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| Thoracic Cancer |
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| Gastrointestinal System Disease |
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| Male Reproductive Organ Cancer |
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| Endocrine Gland Cancer |
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| Autonomic Nervous System Neoplasm |
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| Peripheral Nervous System Neoplasm |
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| Thyroid Gland Medullary Carcinoma |
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| Male Reproductive System Disease |
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| Nasopharyngeal Disease |
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| Respiratory System Disease |
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| Cervix Disease |
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| Uterine Anomalies |
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| Reproductive System Disease |
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| Female Reproductive System Disease |
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| Laryngeal Disease |
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| Nasopharyngeal Carcinoma |
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| Pharynx Cancer |
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| Upper Respiratory Tract Disease |
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| Renal Cell Carcinoma, Nonpapillary |
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| Skin Carcinoma |
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| Human Papillomavirus Infectious Disease |
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| Liver Disease |
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| Urinary System Disease |
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| Colonic Disease |
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| Endocrine System Disease |
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| Connective Tissue Cancer |
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| Prostate Disease |
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| Head And Neck Cancer |
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| Tongue Disease |
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| Cervical Cancer |
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| Lung Cancer |
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| Bone Sarcoma |
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| Breast Disease |
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| Malignant Astrocytoma |
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| Tongue Squamous Cell Carcinoma |
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| Bone Inflammation Disease |
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| Spinal Disease |
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| Lymphatic System Cancer |
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| Bone Cancer |
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| Hormone Producing Pituitary Cancer |
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| Bone Resorption Disease |
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| Pancreas Disease |
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| Lymphatic System Disease |
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| Colorectal Cancer |
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| Central Nervous System Cancer |
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| Biliary Tract Cancer |
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| Colorectal Adenoma |
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| Arteries, Anomalies Of |
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| Bone Remodeling Disease |
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| Immune System Disease |
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| Bile Duct Adenocarcinoma |
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| Gallbladder Disease |
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| Heart Disease |
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| Charcot-Marie-Tooth Disease |
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| Biliary Tract Disease |
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| Ovary Epithelial Cancer |
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| Mouth Disease |
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| Bile Duct Disease |
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| Oral Squamous Cell Carcinoma |
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| Esophageal Cancer |
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| Connective Tissue Disease |
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| Central Nervous System Disease |
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| Melanoma, Uveal |
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| Peripheral Nervous System Disease |
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| Gastric Cancer |
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| Hematologic Cancer |
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| Hepatocellular Carcinoma |
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| Cortical Dysplasia, Complex, With Other Brain Malformations 6 |
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| Integumentary System Disease |
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| Nervous System Disease |
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| Lymphoma, Non-Hodgkin, Familial |
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| Lung Cancer Susceptibility 3 |
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| Squamous Cell Carcinoma, Head And Neck |
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| Melanoma, Cutaneous Malignant 1 |
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| Leukemia, Acute Myeloid |
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| Eye Disease |
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| Leukemia, Acute Lymphoblastic |
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| Skin Disease |
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| Body Mass Index Quantitative Trait Locus 11 |
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| Type 2 Diabetes Mellitus |
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