MIR150 - microRNA 150 Gene
Also Known as MIRN150; mir-150; miRNA150
Species: Homo sapiens
About MIR150
This gene has 1 transcript (splice variant) and 41 orthologues.
Summary
MicroRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted MicroRNA stem-loop. [provided by RefSeq, Sep 2009]
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables mRNA base-pairing translational repressor activity |
IDA
IDA: Inferred from direct assay
|
18667440 | GOA |
| Biological Process GO Annotation | Evidence | References | Source |
|---|---|---|---|
| involved in miRNA-mediated post-transcriptional gene silencing |
IDA
IDA: Inferred from direct assay
|
18667440 | GOA |
| involved in positive regulation of endothelial cell differentiation |
IDA
IDA: Inferred from direct assay
|
23765923 | GOA |
| involved in positive regulation of mesodermal cell differentiation |
IDA
IDA: Inferred from direct assay
|
23765923 | GOA |
| NOT involved in regulation of vascular endothelial cell proliferation |
IDA
IDA: Inferred from direct assay
|
23765923 | GOA |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Rheumatoid Arthritis |
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| Gastric Cancer |
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| Primary Biliary Cholangitis |
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| Polycythemia Vera |
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| Leiomyoma, Uterine |
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| Diffuse Large B-Cell Lymphoma |
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| Kidney Cancer |
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| Endometriosis |
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| Systemic Lupus Erythematosus |
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| Leukemia, Chronic Lymphocytic |
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| Pancreatic Ductal Adenocarcinoma |
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| Lung Cancer |
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| Hepatocellular Carcinoma |
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| Intestinal Schistosomiasis |
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| Bile Duct Disease |
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| Biliary Tract Disease |
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| Lymphatic System Disease |
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| Immune System Disease |
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| Arteries, Anomalies Of |
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| Intermediate Coronary Syndrome |
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| Urinary System Disease |
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| Large Intestine Cancer |
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| Lymphatic System Cancer |
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| Intestinal Disease |
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| Ovary Epithelial Cancer |
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| Respiratory System Disease |
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| Head And Neck Cancer |
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| Bile Duct Cancer |
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| Inherited Metabolic Disorder |
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| Male Reproductive Organ Cancer |
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| Gastrointestinal System Disease |
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| Gastrointestinal System Cancer |
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| Respiratory System Cancer |
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| Colonic Disease |
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| Nasopharyngeal Carcinoma |
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| Stomach Disease |
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| Myocardial Infarction |
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| Endocrine System Disease |
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| Male Reproductive System Disease |
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| Carbohydrate Metabolic Disorder |
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| Bile Duct Adenocarcinoma |
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| Glucose Metabolism Disease |
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| Bladder Disease |
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| Endocrine Gland Cancer |
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| Pharynx Cancer |
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| Bone Marrow Cancer |
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| Esophageal Disease |
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| Reproductive System Disease |
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| Biliary Tract Cancer |
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| Lipoprotein Quantitative Trait Locus |
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| Burkitt Lymphoma |
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| Female Reproductive System Disease |
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| Pancreas Disease |
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| Thoracic Cancer |
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| Nasopharyngeal Disease |
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| Non-Alcoholic Steatohepatitis |
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| Aortic Valve Disease 2 |
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| Rectum Cancer |
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| Prostate Disease |
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| Oral Cavity Cancer |
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| Upper Respiratory Tract Disease |
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| Malignant Exocrine Pancreas Neoplasm |
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| Lymph Node Disease |
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| Disease By Infectious Agent |
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| Ovarian Disease |
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| Colorectal Cancer |
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| Connective Tissue Cancer |
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| Bone Inflammation Disease |
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| Bone Resorption Disease |
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| Malignant Ovarian Surface Epithelial-Stromal Neoplasm |
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| Breast Disease |
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| Lipid Storage Disease |
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| Hematologic Cancer |
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| Central Nervous System Disease |
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| Tongue Squamous Cell Carcinoma |
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| Cervix Disease |
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| Bone Remodeling Disease |
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| Cell Type Benign Neoplasm |
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| Cerebrovascular Disease |
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| Spinal Disease |
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| Malignant Astrocytoma |
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| Myelodysplastic Syndrome |
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| Central Nervous System Cancer |
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| Cardiovascular System Disease |
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| Connective Tissue Disease |
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| Lung Squamous Cell Carcinoma |
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| Esophageal Cancer |
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| Uterine Anomalies |
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| Pleural Disease |
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| Acquired Metabolic Disease |
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| Lysosomal Storage Disease |
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| Overnutrition |
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| Renal Cell Carcinoma, Nonpapillary |
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| Nervous System Disease |
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| Leukemia, Acute Myeloid |
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| Sarcoidosis 1 |
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| Hypertension, Essential |
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| Squamous Cell Carcinoma, Head And Neck |
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| Oral Squamous Cell Carcinoma |
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| Immune Deficiency Disease |
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| Eye Disease |
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| Lung Cancer Susceptibility 3 |
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| Body Mass Index Quantitative Trait Locus 11 |
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| Hirschsprung Disease 1 |
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| Type 2 Diabetes Mellitus |
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Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Mus musculus | MIR150 | MGD | MGI:2676835 |
| Rattus norvegicus | MIR150 | RGD | RGD:2325455 |