Ndufs6 - NADH:ubiquinone oxidoreductase core subunit S6 Gene

Also Known as IP13

Species: Mus musculus

Gene Type: protein coding
Gene ID: 407785

Summary

Acts upstream of or within several processes, including mitochondrion organization; multicellular organism aging; and respiratory electron transport chain. Located in mitochondrion. Part of mitochondrial respiratory chain complex I. Is expressed in limb; respiratory system; and skeleton. Used to study mitochondrial complex I deficiency. Human ortholog(s) of this gene implicated in cervical Cancer and nuclear type mitochondrial complex I deficiency 9. Orthologous to human NDUFS6 (NADH:ubiquinone oxidoreductase subunit S6). [provided by Alliance of Genome Resources, Apr 2022]

Ndufs6 Products (1)

mRNA Protein Name
NM_010888.2 NP_035018.1 NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial precursor

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
acts upstream of or within DNA damage response, signal transduction by p53 class mediator IMP
IMP: Inferred from mutant phenotype
33323934 MGI
acts upstream of or within cell growth IDA
IDA: Inferred from direct assay
33323934 MGI
acts upstream of or within cell growth IMP
IMP: Inferred from mutant phenotype
33323934 MGI
acts upstream of or within cellular senescence IDA
IDA: Inferred from direct assay
33323934 MGI
acts upstream of or within cellular senescence IMP
IMP: Inferred from mutant phenotype
33323934 MGI
acts upstream of or within circulatory system development IMP
IMP: Inferred from mutant phenotype
22474353 MGI
acts upstream of or within fatty acid metabolic process IMP
IMP: Inferred from mutant phenotype
22474353 MGI
acts upstream of or within gene expression IMP
IMP: Inferred from mutant phenotype
33323934 MGI
acts upstream of or within kidney development IMP
IMP: Inferred from mutant phenotype
23320803 MGI
acts upstream of or within mesenchymal stem cell differentiation IDA
IDA: Inferred from direct assay
33323934 MGI
acts upstream of or within mesenchymal stem cell differentiation IMP
IMP: Inferred from mutant phenotype
33323934 MGI
acts upstream of or within mesenchymal stem cell proliferation IDA
IDA: Inferred from direct assay
33323934 MGI
acts upstream of or within mesenchymal stem cell proliferation IMP
IMP: Inferred from mutant phenotype
33323934 MGI
acts upstream of or within mitochondrial respiratory chain complex I assembly IMP
IMP: Inferred from mutant phenotype
23320803 MGI
acts upstream of or within mitochondrion organization IMP
IMP: Inferred from mutant phenotype
22474353 MGI
acts upstream of or within multicellular organism growth IMP
IMP: Inferred from mutant phenotype
22474353 MGI
acts upstream of or within muscle contraction IMP
IMP: Inferred from mutant phenotype
22474353 MGI
acts upstream of or within reactive oxygen species metabolic process IMP
IMP: Inferred from mutant phenotype
33323934 MGI
acts upstream of or within regulation of membrane potential IMP
IMP: Inferred from mutant phenotype
33323934 MGI
acts upstream of or within regulation of mitochondrial membrane potential IMP
IMP: Inferred from mutant phenotype
33323934 MGI
acts upstream of or within reproductive system development IMP
IMP: Inferred from mutant phenotype
22474353 MGI
acts upstream of or within respiratory electron transport chain IMP
IMP: Inferred from mutant phenotype
22474353 MGI
acts upstream of or within stem cell division IDA
IDA: Inferred from direct assay
33323934 MGI
acts upstream of or within stem cell division IMP
IMP: Inferred from mutant phenotype
33323934 MGI
Cellular Component GO Annotation Evidence References Source
is active in intracellular anatomical structure IMP
IMP: Inferred from mutant phenotype
33323934 MGI
is active in mitochondrion IDA
IDA: Inferred from direct assay
33323934 MGI
located in mitochondrion IDA
IDA: Inferred from direct assay
22474353 MGI
is active in mitochondrion IMP
IMP: Inferred from mutant phenotype
33323934 MGI
part of respiratory chain complex I IDA
IDA: Inferred from direct assay
23320803 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial

  • CI-13kD-A

  • NADH dehydrogenase (ubiquinone) Fe-S protein 6

  • NADH dehydrogenase Fe-S protein 6

  • NADH-ubiquinone oxidoreductase 13 kDa-A subunit

  • complex I-13kD-A

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09162 NDUFS6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ndufs6 NCBI NCBI:4726