Ndufs6 - NADH:ubiquinone oxidoreductase core subunit S6 Gene

Mus musculus

Also known as IP13

Gene ID: 407785 | Gene type: protein coding

About Ndufs6

Summary

Acts upstream of or within several processes, including mitochondrion organization; multicellular organism aging; and respiratory electron transport chain. Located in mitochondrion. Part of mitochondrial respiratory chain complex I. Is expressed in limb; respiratory system; and skeleton. Used to study mitochondrial complex I deficiency. Human ortholog(s) of this gene implicated in cervical Cancer and nuclear type mitochondrial complex I deficiency 9. Orthologous to human NDUFS6 (NADH:ubiquinone oxidoreductase subunit S6). [provided by Alliance of Genome Resources, Apr 2022]

Ndufs6 Products(1)

mRNA	Protein	Name
NM_010888.2	NP_035018.1	NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial precursor

Gene Ontology

Biological Process
Cellular Component

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within DNA damage response, signal transduction by p53 class mediator	IMP IMP: Inferred from mutant phenotype	33323934	MGI
acts upstream of or within cell growth	IDA IDA: Inferred from direct assay	33323934	MGI
acts upstream of or within cell growth	IMP IMP: Inferred from mutant phenotype	33323934	MGI
acts upstream of or within cellular senescence	IDA IDA: Inferred from direct assay	33323934	MGI
acts upstream of or within cellular senescence	IMP IMP: Inferred from mutant phenotype	33323934	MGI
acts upstream of or within circulatory system development	IMP IMP: Inferred from mutant phenotype	22474353	MGI
acts upstream of or within fatty acid metabolic process	IMP IMP: Inferred from mutant phenotype	22474353	MGI
acts upstream of or within gene expression	IMP IMP: Inferred from mutant phenotype	33323934	MGI
acts upstream of or within kidney development	IMP IMP: Inferred from mutant phenotype	23320803	MGI
acts upstream of or within mesenchymal stem cell differentiation	IDA IDA: Inferred from direct assay	33323934	MGI
acts upstream of or within mesenchymal stem cell differentiation	IMP IMP: Inferred from mutant phenotype	33323934	MGI
acts upstream of or within mesenchymal stem cell proliferation	IDA IDA: Inferred from direct assay	33323934	MGI
acts upstream of or within mesenchymal stem cell proliferation	IMP IMP: Inferred from mutant phenotype	33323934	MGI
acts upstream of or within mitochondrial respiratory chain complex I assembly	IMP IMP: Inferred from mutant phenotype	23320803	MGI
acts upstream of or within mitochondrion organization	IMP IMP: Inferred from mutant phenotype	22474353	MGI
acts upstream of or within multicellular organism growth	IMP IMP: Inferred from mutant phenotype	22474353	MGI
acts upstream of or within muscle contraction	IMP IMP: Inferred from mutant phenotype	22474353	MGI
acts upstream of or within reactive oxygen species metabolic process	IMP IMP: Inferred from mutant phenotype	33323934	MGI
acts upstream of or within regulation of membrane potential	IMP IMP: Inferred from mutant phenotype	33323934	MGI
acts upstream of or within regulation of mitochondrial membrane potential	IMP IMP: Inferred from mutant phenotype	33323934	MGI
acts upstream of or within reproductive system development	IMP IMP: Inferred from mutant phenotype	22474353	MGI
acts upstream of or within respiratory electron transport chain	IMP IMP: Inferred from mutant phenotype	22474353	MGI
acts upstream of or within stem cell division	IDA IDA: Inferred from direct assay	33323934	MGI
acts upstream of or within stem cell division	IMP IMP: Inferred from mutant phenotype	33323934	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
is active in intracellular anatomical structure	IMP IMP: Inferred from mutant phenotype	33323934	MGI
is active in mitochondrion	IDA IDA: Inferred from direct assay	33323934	MGI
located in mitochondrion	IDA IDA: Inferred from direct assay	22474353	MGI
is active in mitochondrion	IMP IMP: Inferred from mutant phenotype	33323934	MGI
part of respiratory chain complex I	IDA IDA: Inferred from direct assay	23320803	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial

CI-13kD-A	NADH dehydrogenase (ubiquinone) Fe-S protein 6
NADH dehydrogenase Fe-S protein 6	NADH-ubiquinone oxidoreductase 13 kDa-A subunit
complex I-13kD-A

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09162	NDUFS6 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ndufs6	NCBI	NCBI:4726

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