MIR17HG - miR-17-92a-1 cluster host gene Gene

Also Known as MIHG1; MIRH1; FGLDS2; MIRHG1; C13orf25; LINC00048; miR-17-92; NCRNA00048

Species: Homo sapiens

Gene Type: ncRNA
Gene ID: 407975

About MIR17HG

Cytogenetic location: 13q31.3 Genomic coordinates (GRCh38): 13:91,347,820-91,354,575 (from NCBI)

This gene has 5 transcripts (splice variants) and is associated with 2 phenotypes. Ubiquitous expression in lymph node (RPKM 1.4), appendix (RPKM 1.3) and 25 other tissues.

Summary

This gene is the host gene for the MIR17-92 cluster, a group of at least six MicroRNAs (miRNAs) that may be involved in cell survival, proliferation, differentiation, and angiogenesis. Amplification of this gene has been found in several lymphomas and solid tumors. Two non-protein coding transcript variants have been found for this host gene, but only the longest is a polycistronic transcript containing the MIR17-92 cluster. [provided by RefSeq, May 2012]

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
involved in miRNA-mediated post-transcriptional gene silencing IDA
IDA: Inferred from direct assay
23271053 GOA
involved in positive regulation of muscle hyperplasia IDA
IDA: Inferred from direct assay
23271053 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Related Diseases

Diseases Alias
Feingold Syndrome 2

  • FGLDS2

  • Feingold Syndrome Type 2

  • Brachydactyly With Short Stature And Microcephaly

  • Brachydactyly-Short Stature-Microcephaly Syndrome

  • Brunner-Winter Syndrome Type 2

  • Fs2

  • Mmt Type 2

  • Microcephaly-Digital Anomalies-Normal Intelligence Syndrome Type 2

  • Microcephaly-Intellectual Disability-Tracheoesophageal Fistula Syndrome Type 2

  • Feingold Syndrome, Type 2
Diffuse Large B-Cell Lymphoma

  • Dlbcl

  • Diffuse Large B-Cell Lymphoma, Not Otherwise Specified

  • Large B-Cell Diffuse Lymphoma

  • Lymphoma, Large B-Cell, Diffuse

  • Dlbcl - [Diffuse Large B-Cell Lymphoma]

  • Diffuse Large Beta Cell Lymphoma
Glioblastoma

  • Glioblastoma Multiforme

  • Gbm

  • Adult Glioblastoma Multiforme

  • Grade Iv Adult Astrocytic Tumor

  • Primary Glioblastoma Multiforme

  • Spongioblastoma Multiforme

  • Adult Glioblastoma

  • Primary Glioblastoma
B-Cell Lymphoma

  • Lymphoma, B-Cell

  • B-Cell Lymphomas

  • B-Cell Lymphocytic Neoplasm

  • Lymphoma B-Cell

  • B-Cell Lymphoma Nos
Feingold Syndrome 1

  • Feingold Syndrome

  • Oculodigitoesophagoduodenal Syndrome

  • Oded Syndrome

  • Microcephaly-Oculo-Digito-Esophageal-Duodenal Syndrome

  • Digital Anomalies With Short Palpebral Fissures And Atresia Of Esophagus Or Duodenum

  • FGLDS1

  • Mmt Syndrome

  • Brunner-Winter Syndrome

  • Feingold Syndrome Type 1

  • Oded

  • Moded

  • Fglds

  • Microcephaly-Digital Anomalies-Normal Intelligence Syndrome

  • Moded Syndrome

  • Oculo-Digito-Esophageal-Duodenal Syndrome

  • Microcephaly, Mental Retardation, And Tracheoesophageal Fistula Syndrome

  • Microcephaly And Digital Abnormalities With Normal Intelligence

  • Digital Anomalies With Short Palpebral Fissures And Atresia Of Esophagus, Or Duodenum

  • Microcephaly-Mesobrachyphalangy-Tracheoesophageal Fistula Syndrome

  • Microcephaly-Oculo-Digito-Esophageal-Duodenal Syndrome

  • Oculo-Digito-Esophagoduodental Syndrome

  • Fs

  • Mmt

  • Microcephaly-Intellectual Disability-Tracheoesophageal Fistula Syndrome

  • Microcephaly-Oculo-Digito-Esophageal-Duodenal Syndrome Syndrome

  • Brunner-Winter Syndrome Type 1

  • Digital Anomalies With Short Palpebral Fissures And Atresia Of Esophagus Or Duodenum Type 1

  • Fs1

  • Mmt Type 1

  • Moded Syndrome Type 1

  • Microcephaly-Digital Anomalies-Normal Intelligence Syndrome Type 1

  • Microcephaly-Intellectual Disability-Tracheoesophageal Fistula Syndrome Type 1

  • Microcephaly-Oculo-Digito-Esophageal-Duodenal Syndrome Syndrome Type 1

  • Oded Syndrome Type 1

  • Oculo-Digito-Esophageal-Duodenal Syndrome Type 1

  • Feingold Syndrome, Type 1
Lung Cancer

  • Lung Carcinoma

  • Non-Small Cell Lung Carcinoma

  • Lung Cancer, Susceptibility To

  • Lung Cancer, Protection Against

  • Adenocarcinoma Of Lung, Somatic

  • Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

  • Nonsmall Cell Lung Cancer

  • Lung Neoplasm

  • Carcinoma Of Lung

  • Lung Non-Small Cell Carcinoma

  • Non-Small Cell Lung Cancer

  • Nsclc

  • Lung Neoplasms

  • Malignant Neoplasm Of Lung

  • Alveolar Cell Carcinoma

  • Nonsmall Cell Lung Cancer, Somatic

  • Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

  • Nonsmall Cell Lung Cancer, Susceptibility To

  • Lung Cancer, Somatic

  • Lung Cancer, Resistance To

  • Cancer Of Lung

  • Cancer Of Bronchus

  • Cancer Of The Lung

  • Lung Malignancies

  • Lung Malignant Tumors

  • Malignant Lung Tumor

  • Malignant Tumor Of Lung

  • Pulmonary Cancer

  • Pulmonary Carcinoma

  • Pulmonary Neoplasms

  • Respiratory Carcinoma

  • LNCR

  • Adenocarcinoma Of Lung

  • Neoplasm Of Lung

  • Cancer Lung

  • Carcinoma Non-Small Cell Lung

  • Carcinoma, Non-Small-Cell Lung

  • Lung Cancers

  • Lung Carcinomas

  • Cancer, Lung

  • Cancer, Lung, Non-Small Cell

  • Primary Malignant Neoplasm Of Lung

  • Bronchioloalveolar Adenocarcinoma
Lymphoma

  • Lymphoid Cancer

  • Lymphomas

  • Lymphoid Cancers

  • Lymphoid Neoplasm

  • Lymphoma Nos

  • Nhl - [Non-Hodgkin Lymphoma]

  • Non-Hodgkin Lymphoma

  • Non-Hodgkin Lymphoma, Nos

  • Non-Hodgkin Malignant Lymphoma Nos
Burkitt Lymphoma

  • Burkitt'S Lymphoma

  • BL

  • Burkitt Lymphoma, Somatic

  • Burkitt Lymphoma/Leukaemia

  • Burkitt'S Tumor

  • Burkitt'S Tumor Or Lymphoma

  • Malignant Lymphoma, Burkitt'S Type

  • Small Non-Cleaved Cell Lymphoma, Burkitt'S Type

  • Small Non-Cleaved Cell Lymphoma

  • Burkitt Tumor

  • Burkitts Lymphoma

  • Lymphoma, Small Noncleaved-Cell

  • Burkitt Tumour

  • Diffuse Small Noncleaved Malignant Burkitt Lymphoma

  • Malignant Burkitt Lymphoma

  • “Burkitt-Like” Lymphoma

  • Undifferentiated Burkitt Lymphoma

  • Small Noncleaved Cell Burkitt Lymphoma
Brachydactyly
Rhabdomyosarcoma
Medulloblastoma

  • MDB

  • Cpnet

  • Localized Primitive Neuroectodermal Tumor

  • Classic Medulloblastoma

  • Medulloblastoma Predisposition Syndrome

  • Medulloblastoma, Somatic

  • Brain Medulloblastoma

  • Cns Pnet

  • Infratentorial Primitive Neuroectodermal Tumor

  • Neuroectodermal Tumors, Primitive

  • Medulloblastomas

  • Desmoplastic Medulloblastoma

  • Medulloblastoma, With Extensive Nodularity

  • Medulloblastoma Of Unspecified Site

  • Medullomyoblastoma Of Unspecified Site
Microcephaly

  • Microencephaly

  • Microcephalus

  • Microcephalic

  • Nanocephaly

  • Congenital Microcephaly

  • Brain Hypoplasia

  • Brain Nondevelopment

  • Cephalic Hypoplasia

  • Undeveloped Cerebrum

  • Undeveloped Brain

  • Micrencephalon

  • Micrencephaly
Mantle Cell Lymphoma

  • Lymphoma, Mantle Cell

  • Lcm

  • Mcl

  • Mantle Zone Lymphoma

  • Lymphoma Mantle-Cell

  • Lymphoma, Mantle-Cell

  • Malignant Lymphoma, Lymphocytic, Intermediate Differentiation, Diffuse

  • Malignant Lymphoma - Lymphocytic, Intermediate Differentiation

  • Diffuse Small Cleaved-Cell Lymphoma

  • Diffuse Small Cleaved Cell Malignant Lymphoma

  • Small Cleaved Cell Non-Hodgkin Lymphoma

  • Diffuse Non-Hodgkin Small Cleaved Cell Lymphoma

  • Malignant Lymphomatous Polyposis

  • Malignant Small Cell, Noncleaved, Diffuse Lymphoma

  • Malignant Undifferentiated Cell, Non-Burkitt Lymphoma

  • Cleaved Cell Lymphoma

  • Small Cell Mantle Cell Lymphoma

  • Small Cleaved Cell Malignant Lymphoma
Leukemia, Chronic Lymphocytic

  • Chronic Lymphocytic Leukemia

  • B-Cell Chronic Lymphocytic Leukemia

  • CLL

  • B-Cell Chronic Lymphoid Leukemia

  • Chronic Lymphatic Leukemia

  • Chronic Lymphocytic Leukaemia

  • Lymphoplasmacytic Leukemia

  • Small Lymphocytic Lymphoma

  • Leukemia, Chronic Lymphatic

  • B-Cell Chronic Lymphocytic Leukaemia

  • Chronic Lymphatic Leukaemia

  • Lymphoplasmacytic Leukaemia

  • B Cell Chronic Lymphocytic Leukemia

  • Chronic B-Cell Lymphocytic Leukemia

  • Leukemia, Lymphocytic, Chronic

  • B-Cll

  • Chronic Lymphoid Leukemia

  • Leukemia Lymphocytic Chronic

  • Lymphoma Small Lymphocytic

  • Leukemia, Lymphocytic, Chronic, B-Cell
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Mus musculus MIR17HG MGD MGI:1923207