MIR17HG - miR-17-92a-1 cluster host gene Gene

Homo sapiens

Also known as MIHG1; MIRH1; FGLDS2; MIRHG1; C13orf25; LINC00048; miR-17-92; NCRNA00048

Gene ID: 407975 | Gene type: ncRNA

About MIR17HG

Cytogenetic location: 13q31.3 Genomic coordinates (GRCh38): 13:91,347,820-91,354,575 (from NCBI)

This gene has 5 transcripts (splice variants) and is associated with 2 phenotypes. Ubiquitous expression in lymph node (RPKM 1.4), appendix (RPKM 1.3) and 25 other tissues.

Summary

This gene is the host gene for the MIR17-92 cluster, a group of at least six MicroRNAs (miRNAs) that may be involved in cell survival, proliferation, differentiation, and angiogenesis. Amplification of this gene has been found in several lymphomas and solid tumors. Two non-protein coding transcript variants have been found for this host gene, but only the longest is a polycistronic transcript containing the MIR17-92 cluster. [provided by RefSeq, May 2012]

Gene Ontology

Biological Process

Biological Process GO Annotation	Evidence	Reference	Source
involved in miRNA-mediated post-transcriptional gene silencing	IDA IDA: Inferred from direct assay	23271053	GOA
involved in positive regulation of muscle hyperplasia	IDA IDA: Inferred from direct assay	23271053	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Related Diseases

Diseases

Alias

Feingold Syndrome 2

FGLDS2	Feingold Syndrome Type 2
Brachydactyly With Short Stature And Microcephaly	Brachydactyly-Short Stature-Microcephaly Syndrome
Brunner-Winter Syndrome Type 2	Fs2
Mmt Type 2	Microcephaly-Digital Anomalies-Normal Intelligence Syndrome Type 2
Microcephaly-Intellectual Disability-Tracheoesophageal Fistula Syndrome Type 2	Feingold Syndrome, Type 2

Diffuse Large B-Cell Lymphoma

Dlbcl	Diffuse Large B-Cell Lymphoma, Not Otherwise Specified
Large B-Cell Diffuse Lymphoma	Lymphoma, Large B-Cell, Diffuse
Dlbcl - [Diffuse Large B-Cell Lymphoma]	Diffuse Large Beta Cell Lymphoma

Glioblastoma

Glioblastoma Multiforme	Gbm
Adult Glioblastoma Multiforme	Grade Iv Adult Astrocytic Tumor
Primary Glioblastoma Multiforme	Spongioblastoma Multiforme
Adult Glioblastoma	Primary Glioblastoma

B-Cell Lymphoma

Lymphoma, B-Cell	B-Cell Lymphomas
B-Cell Lymphocytic Neoplasm	Lymphoma B-Cell
B-Cell Lymphoma Nos

Feingold Syndrome 1

Feingold Syndrome	Oculodigitoesophagoduodenal Syndrome
Oded Syndrome	Microcephaly-Oculo-Digito-Esophageal-Duodenal Syndrome
Digital Anomalies With Short Palpebral Fissures And Atresia Of Esophagus Or Duodenum	FGLDS1
Mmt Syndrome	Brunner-Winter Syndrome
Feingold Syndrome Type 1	Oded
Moded	Fglds
Microcephaly-Digital Anomalies-Normal Intelligence Syndrome	Moded Syndrome
Oculo-Digito-Esophageal-Duodenal Syndrome	Microcephaly, Mental Retardation, And Tracheoesophageal Fistula Syndrome
Microcephaly And Digital Abnormalities With Normal Intelligence	Digital Anomalies With Short Palpebral Fissures And Atresia Of Esophagus, Or Duodenum
Microcephaly-Mesobrachyphalangy-Tracheoesophageal Fistula Syndrome	Microcephaly-Oculo-Digito-Esophageal-Duodenal Syndrome
Oculo-Digito-Esophagoduodental Syndrome	Fs
Mmt	Microcephaly-Intellectual Disability-Tracheoesophageal Fistula Syndrome
Microcephaly-Oculo-Digito-Esophageal-Duodenal Syndrome Syndrome	Brunner-Winter Syndrome Type 1
Digital Anomalies With Short Palpebral Fissures And Atresia Of Esophagus Or Duodenum Type 1	Fs1
Mmt Type 1	Moded Syndrome Type 1
Microcephaly-Digital Anomalies-Normal Intelligence Syndrome Type 1	Microcephaly-Intellectual Disability-Tracheoesophageal Fistula Syndrome Type 1
Microcephaly-Oculo-Digito-Esophageal-Duodenal Syndrome Syndrome Type 1	Oded Syndrome Type 1
Oculo-Digito-Esophageal-Duodenal Syndrome Type 1	Feingold Syndrome, Type 1

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Susceptibility To	Lung Cancer, Protection Against
Adenocarcinoma Of Lung, Somatic	Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In
Nonsmall Cell Lung Cancer	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

Lymphoma

Lymphoid Cancer	Lymphomas
Lymphoid Cancers	Lymphoid Neoplasm
Lymphoma Nos	Nhl - [Non-Hodgkin Lymphoma]
Non-Hodgkin Lymphoma	Non-Hodgkin Lymphoma, Nos
Non-Hodgkin Malignant Lymphoma Nos

Burkitt Lymphoma

Burkitt'S Lymphoma	BL
Burkitt Lymphoma, Somatic	Burkitt Lymphoma/Leukaemia
Burkitt'S Tumor	Burkitt'S Tumor Or Lymphoma
Malignant Lymphoma, Burkitt'S Type	Small Non-Cleaved Cell Lymphoma, Burkitt'S Type
Small Non-Cleaved Cell Lymphoma	Burkitt Tumor
Burkitts Lymphoma	Lymphoma, Small Noncleaved-Cell
Burkitt Tumour	Diffuse Small Noncleaved Malignant Burkitt Lymphoma
Malignant Burkitt Lymphoma	“Burkitt-Like” Lymphoma
Undifferentiated Burkitt Lymphoma	Small Noncleaved Cell Burkitt Lymphoma

Brachydactyly

Rhabdomyosarcoma

Medulloblastoma

MDB	Cpnet
Localized Primitive Neuroectodermal Tumor	Classic Medulloblastoma
Medulloblastoma Predisposition Syndrome	Medulloblastoma, Somatic
Brain Medulloblastoma	Cns Pnet
Infratentorial Primitive Neuroectodermal Tumor	Neuroectodermal Tumors, Primitive
Medulloblastomas	Desmoplastic Medulloblastoma
Medulloblastoma, With Extensive Nodularity	Medulloblastoma Of Unspecified Site
Medullomyoblastoma Of Unspecified Site

Microcephaly

Microencephaly	Microcephalus
Microcephalic	Nanocephaly
Congenital Microcephaly	Brain Hypoplasia
Brain Nondevelopment	Cephalic Hypoplasia
Undeveloped Cerebrum	Undeveloped Brain
Micrencephalon	Micrencephaly

Mantle Cell Lymphoma

Lymphoma, Mantle Cell	Lcm
Mcl	Mantle Zone Lymphoma
Lymphoma Mantle-Cell	Lymphoma, Mantle-Cell
Malignant Lymphoma, Lymphocytic, Intermediate Differentiation, Diffuse	Malignant Lymphoma - Lymphocytic, Intermediate Differentiation
Diffuse Small Cleaved-Cell Lymphoma	Diffuse Small Cleaved Cell Malignant Lymphoma
Small Cleaved Cell Non-Hodgkin Lymphoma	Diffuse Non-Hodgkin Small Cleaved Cell Lymphoma
Malignant Lymphomatous Polyposis	Malignant Small Cell, Noncleaved, Diffuse Lymphoma
Malignant Undifferentiated Cell, Non-Burkitt Lymphoma	Cleaved Cell Lymphoma
Small Cell Mantle Cell Lymphoma	Small Cleaved Cell Malignant Lymphoma

Leukemia, Chronic Lymphocytic

Chronic Lymphocytic Leukemia	B-Cell Chronic Lymphocytic Leukemia
CLL	B-Cell Chronic Lymphoid Leukemia
Chronic Lymphatic Leukemia	Chronic Lymphocytic Leukaemia
Lymphoplasmacytic Leukemia	Small Lymphocytic Lymphoma
Leukemia, Chronic Lymphatic	B-Cell Chronic Lymphocytic Leukaemia
Chronic Lymphatic Leukaemia	Lymphoplasmacytic Leukaemia
B Cell Chronic Lymphocytic Leukemia	Chronic B-Cell Lymphocytic Leukemia
Leukemia, Lymphocytic, Chronic	B-Cll
Chronic Lymphoid Leukemia	Leukemia Lymphocytic Chronic
Lymphoma Small Lymphocytic	Leukemia, Lymphocytic, Chronic, B-Cell

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	MIR17HG	MGD	MGI:1923207

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