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KLK12 - kallikrein related peptidase 12 Gene

Also Known as KLKL5; KLK-L5

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 43849

About KLK12

Cytogenetic location: 19q13.41 Genomic coordinates (GRCh38): 19:51,029,094-51,035,002 (from NCBI)

This gene has 8 transcripts (splice variants), 173 orthologues and 12 paralogues. Biased expression in esophagus (RPKM 4.6), salivary gland (RPKM 1.0) and 4 other tissues.

Summary

Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel Cancer and Other disease biomarkers. This gene is one of the fifteen Kallikrein subfamily members located in a cluster on chromosome 19. Alternate splicing of this gene results in three transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

KLK12 Products (7)

mRNA	Protein	Name
NM_001370125.1	NP_001357054.1	kallikrein-12 isoform 2 precursor
NM_001370126.1	NP_001357055.1	kallikrein-12 isoform 4
NM_001370127.1	NP_001357056.1	kallikrein-12 isoform 3
NM_001370128.1	NP_001357057.1	kallikrein-12 isoform 3
NM_019598.3	NP_062544.1	kallikrein-12 isoform 1 precursor
NM_145894.2	NP_665901.1	kallikrein-12 isoform 2 precursor
NM_145895.2	NP_665902.2	kallikrein-12 isoform 3

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables peptidase activity	IDA IDA: Inferred from direct assay	21628462	GOA
enables serine-type peptidase activity	IDA IDA: Inferred from direct assay	15300858	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in proteolysis	IDA IDA: Inferred from direct assay	21628462	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KLK12 Protein Structure

Trypsin

0
100
200
248 a.a.

Protein Preferred Names	Protein Names
kallikrein-12	kallikrein-like protein 5

Related Diseases

Diseases	Alias
Autosomal Recessive Congenital Ichthyosis	Lamellar Ichthyosis Congenital Ichthyosiform Erythroderma Li Congenital Nonbullous Ichthyosiform Erythroderma Arci Congenital Lamellar Ichthyosis Nonbullous Congenital Ichthyosiform Erythroderma Cie Congenital Non-Bullous Ichthyosiform Erythroderma Erythrodermic Ichthyosis Nbcie Ncie Non-Bullous Congenital Ichthyosiform Erythroderma Collodion Baby Ichthyosis, Lamellar Non Bullous Congenital Ichthyosiform Erythroderma Ichthyosiform Erythroderma, Brocq Congenital, Nonbullous Form Ichthyosiform Erythroderma, Congenital, Nonbullous, 1 Collodion Baby Syndrome Ichthyoses, Lamellar Nbie Nonbullous Ichthyosiform Erythroderma Classic Lamellar Ichthyosis Ichthyosiform Erythroderma Nonbullous Congenital Ichthyosiform Erythroderma Congenital Ichthyosis, Congenital, Autosomal Recessive Ichthyosiform Erythroderma, Congenital Collodion Fetus Non-Bullous Ichthyosiform Erythroderma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07376	KLK12 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	KLK12	MGD	MGI:1916761
Bos taurus	KLK12	VGNC	VGNC:30674
Felis catus	KLK12	VGNC	VGNC:67963
Rattus norvegicus	KLK12	RGD	RGD:1308975
Macaca mulatta	KLK12	VGNC	VGNC:74190
Others	KLK12	NCBI