TMEM150C - transmembrane protein 150C Gene

Also Known as TTN3

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 441027

About TMEM150C

Cytogenetic location: 4q21.22 Genomic coordinates (GRCh38): 4:82,483,176-82,562,253 (from NCBI)

This gene has 4 transcripts (splice variants), 193 orthologues and 4 paralogues. Ubiquitous expression in ovary (RPKM 19.6), adrenal (RPKM 16.2) and 23 other tissues.

Summary

This gene encodes a transmembrane protein component of a mechanosensitve ion channel that is activated by mechanical stimuli in various cell types and confers slowly adapting, mechanically activated currents in dorsal root ganglion neurons. Mechanically activated ion channels are sensors that are critical for hearing, touch, pain, and blood pressure regulation. [provided by RefSeq, Jul 2017]

TMEM150C Products (3)

mRNA Protein Name
NM_001080506.3 NP_001073975.1 transmembrane protein 150C isoform 1
NM_001353454.2 NP_001340383.1 transmembrane protein 150C isoform 2
NM_001353455.2 NP_001340384.1 transmembrane protein 150C isoform 3

Gene Ontology

  • Cellular Component
Cellular Component GO Annotation Evidence References Source
located in plasma membrane IDA
IDA: Inferred from direct assay
25608530 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TMEM150C Protein Structure

Frag1

Frag1: Frag1/DRAM/Sfk1 family (9 - 217)

  • 0
  • 100
  • 200
  • 249 a.a.
Protein Preferred Names Protein Names

transmembrane protein 150C

  • tentonin 3

Related Diseases

Diseases Alias
Malignant Hemangioma
Chromosome 4q21 Deletion Syndrome

  • 4q21 Microdeletion Syndrome

  • Monosomy 4q21

  • Del(4)(Q21)

  • Chromosome Deletion Syndrome 4q21
Dehydrated Hereditary Stomatocytosis 1 With Or Without Pseudohyperkalemia And/Or Perinatal Edema

  • Dehydrated Hereditary Stomatocytosis

  • Hereditary Xerocytosis

  • Xerocytosis, Hereditary

  • Pshk1

  • Pseudohyperkalemia Edinburgh

  • Dehydrated Hereditary Stomatocytosis With Or Without Pseudohyperkalemia And/Or Perinatal Edema

  • DHS1

  • Dhs

  • Hereditary Desiccytosis

  • Dehydrated Hereditary Stomatocytosis 1

  • Desiccytosis, Hereditary

  • Pseudohyperkalemia, Familial, 1, Due To Red Cell Leak

  • Pseudohyperkalemia Familial 1, Due To Red Cell Leak

  • Desiccytosis Hereditary

  • Xerocytosis Hereditary

  • Familial Pseudohyperkalemia 1 Due To Red Cell Leak

  • Stomatocytosis, Dehydrated, Hereditary, With/Without Pseudohyperkalemia And/Or Perinatal Edema

  • Xerocytosis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14672 TMEM150C Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus TMEM150C VGNC VGNC:66284
Mus musculus TMEM150C MGD MGI:3041258
Bos taurus TMEM150C VGNC VGNC:35982
Rattus norvegicus TMEM150C RGD RGD:1306105
Macaca mulatta TMEM150C VGNC VGNC:100282
Canis familiaris TMEM150C VGNC VGNC:47483
Others TMEM150C NCBI