LGSN - lengsin, lens protein with glutamine synthetase domain Gene

Homo sapiens

Also known as LGS; GLULD1

Gene ID: 51557 | Gene type: protein coding

About LGSN

Cytogenetic location: 6q12 Genomic coordinates (GRCh38): 6:63,275,951-63,573,607 (from NCBI)

This gene has 4 transcripts (splice variants), 201 orthologues and 1 paralogue. Low expression observed in reference dataset.

Summary

This gene encodes a protein with similarity to the GS I members of the glutamine synthetase superfamily. The encoded protein is referred to as a pseudo-glutamine synthetase because it has no glutamine synthesis activity and may function as a chaperone protein. This protein is localized to the lens and may be associated with cataract disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2009]

LGSN Products(2)

mRNA	Protein	Name
NM_001143940.2	NP_001137412.1	lengsin isoform b
NM_016571.3	NP_057655.2	lengsin isoform a

LGSN Protein Structure

Gln-synt_N

Gln-synt_C

0
100
200
300
400
509 a.a.

Protein Preferred Names

Protein Names

lengsin

glutamate-ammonia ligase (glutamine synthase) domain containing 1

Related Diseases

Diseases

Alias

Mature Cataract

Total Or Mature Cataract

Total, Mature Senile Cataract

Presbyopia

Subnormal Accommodation

Accommodation Insufficiency Of Old Age

Cataract

Cataracts	Cat - [Cataract]
Cataract Form	Lens Opacity
Lens Opacities

Retinitis Pigmentosa

RP	Rod-Cone Dystrophy
Autosomal Recessive Retinitis Pigmentosa	Non-Syndromic Retinitis Pigmentosa
Pericentral Pigmentary Retinopathy	Pigmentary Retinopathy
Tapetoretinal Degeneration	Rcd
Retinitis Pigmentosa Autosomal Recessive	ARRP
Retinitis Pigmentosa, Autosomal Recessive	Retinitis Pigmentosa 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07621	LGSN Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	LGSN	VGNC	VGNC:74093
Felis catus	LGSN	VGNC	VGNC:63221
Rattus norvegicus	LGSN	RGD	RGD:727925
Canis familiaris	LGSN	VGNC	VGNC:42656
Bos taurus	LGSN	VGNC	VGNC:30863
Mus musculus	LGSN	MGD	MGI:2672844