CLIC6 - chloride intracellular channel 6 Gene

Also Known as CLIC1L

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 54102

About CLIC6

Cytogenetic location: 21q22.12 Genomic coordinates (GRCh38): 21:34,668,994-34,718,223 (from NCBI)

This gene has 2 transcripts (splice variants), 223 orthologues and 14 paralogues. Biased expression in stomach (RPKM 24.4), thyroid (RPKM 6.8) and 10 other tissues.

Summary

This gene encodes a member of the chloride intracellular channel family of proteins. The gene is part of a large triplicated region found on chromosomes 1, 6, and 21. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2015]

CLIC6 Products (2)

mRNA Protein Name
NM_001317009.2 NP_001303938.1 chloride intracellular channel protein 6 isoform 1
NM_053277.3 NP_444507.1 chloride intracellular channel protein 6 isoform 2

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables chloride channel activity IDA
IDA: Inferred from direct assay
37838179 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CLIC6 Protein Structure

GST_N_3

GST_N_3: Glutathione S-transferase, N-terminal domain (487 - 553)

GST_C_2

GST_C_2: Glutathione S-transferase, C-terminal domain (589 - 674)

  • 0
  • 200
  • 400
  • 600
  • 704 a.a.
Protein Preferred Names Protein Names

chloride intracellular channel protein 6

  • chloride channel form A

Related Diseases

Diseases Alias
Deafness, Autosomal Recessive 103

  • DFNB103

  • Autosomal Recessive Nonsyndromic Deafness 103

  • Autosomal Recessive Deafness 103

  • Deafness, Autosomal Recessive, 103

  • Deafness, Autosomal Recessive, Type 103
Retinitis Pigmentosa 20

  • RP20

  • Retinitis Pigmentosa, Type 20
Retinitis Pigmentosa 25

  • RP25

  • Retinitis Pigmentosa-25

  • Retinitis Pigmentosa, Type 25
Deafness, Autosomal Recessive 102

  • DFNB102

  • Autosomal Recessive Nonsyndromic Deafness 102

  • Autosomal Recessive Deafness 102

  • Deafness, Autosomal Recessive, 102

  • Deafness, Autosomal Recessive, Type 102
Ischemic Neuropathy

  • Ischemic Peripheral Neuropathy
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02808 CLIC6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20886 Clic6 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27403 Clic6 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris CLIC6 VGNC VGNC:53024
Felis catus CLIC6 VGNC VGNC:102674
Mus musculus CLIC6 MGD MGI:2146607
Rattus norvegicus CLIC6 RGD RGD:727938
Macaca mulatta CLIC6 VGNC VGNC:71256
Others CLIC6 NCBI