WRAP53 - WD repeat containing antisense to TP53 Gene

Also Known as DKCB3; TCAB1; WDR79

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 55135

About WRAP53

Cytogenetic location: 17p13.1 Genomic coordinates (GRCh38): 17:7,686,071-7,703,502 (from NCBI)

This gene has 16 transcripts (splice variants), 190 orthologues and is associated with 3 phenotypes. Ubiquitous expression in lymph node (RPKM 2.8), testis (RPKM 2.5) and 25 other tissues.

Summary

This gene encodes an essential component of the Telomerase holoenzyme complex, a ribonucleoprotein complex required for telomere synthesis. This protein is enriched in Cajal bodies, nuclear sites of RNP processing that are important for Telomerase function. It interacts with dyskerin, TERT and TERC, Other components of active Telomerase, and with small Cajal body RNAs (scaRNAs), which are involved in modifying splicing RNAs. This mRNA also functions as a p53 antisense transcript, that regulates endogenous p53 mRNA levels and further induction of p53 protein by targeting the 5' untranslated region of p53 mRNA. Alternatively spliced transcript variants which differ only in the 5' UTR have been found for this gene. [provided by RefSeq, Mar 2011]

WRAP53 Products (4)

mRNA	Protein	Name
NM_001143990.2	NP_001137462.1	telomerase Cajal body protein 1
NM_001143991.2	NP_001137463.1	telomerase Cajal body protein 1
NM_001143992.2	NP_001137464.1	telomerase Cajal body protein 1
NM_018081.2	NP_060551.2	telomerase Cajal body protein 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables RNA binding	IDA IDA: Inferred from direct assay	19179534	GOA
enables RNA binding	IPI IPI: Inferred from physical interaction	20351177	GOA
enables RNA folding chaperone	IDA IDA: Inferred from direct assay	19179534	GOA
enables histone binding	IPI IPI: Inferred from physical interaction	26734725	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	21072240	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	19179534	GOA
enables protein carrier chaperone	IMP IMP: Inferred from mutant phenotype	25467444	GOA
enables protein-containing complex binding	IDA IDA: Inferred from direct assay	25467444	GOA
enables protein-folding chaperone binding	IPI IPI: Inferred from physical interaction	25467444	GOA
enables telomerase RNA binding	IDA IDA: Inferred from direct assay	22547674	GOA
enables telomerase RNA binding	IPI IPI: Inferred from physical interaction	20351177	GOA
enables ubiquitin protein ligase binding	IPI IPI: Inferred from physical interaction	25512560	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in Cajal body organization	IMP IMP: Inferred from mutant phenotype	21072240	GOA
involved in RNA folding	IDA IDA: Inferred from direct assay	29804836	GOA
involved in positive regulation of DNA repair	IDA IDA: Inferred from direct assay	25512560	GOA
involved in positive regulation of double-strand break repair	IDA IDA: Inferred from direct assay	27715493	GOA
involved in positive regulation of double-strand break repair via homologous recombination	IDA IDA: Inferred from direct assay	25512560	GOA
involved in positive regulation of double-strand break repair via nonhomologous end joining	IDA IDA: Inferred from direct assay	25512560	GOA
involved in positive regulation of establishment of protein localization to telomere	IMP IMP: Inferred from mutant phenotype	25467444	GOA
acts upstream of positive regulation of telomere maintenance via telomerase	IDA IDA: Inferred from direct assay	23685356	GOA
involved in protein localization to Cajal body	IDA IDA: Inferred from direct assay	22547674	GOA
involved in scaRNA localization to Cajal body	IDA IDA: Inferred from direct assay	19285445	GOA
involved in scaRNA localization to Cajal body	IMP IMP: Inferred from mutant phenotype	25467444	GOA
involved in telomerase RNA localization to Cajal body	IMP IMP: Inferred from mutant phenotype	25467444	GOA
involved in telomere formation via telomerase	IMP IMP: Inferred from mutant phenotype	19179534	GOA
involved in telomere maintenance via telomerase	IDA IDA: Inferred from direct assay	29695869	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in Cajal body	IDA IDA: Inferred from direct assay	19179534	GOA
located in Cajal body	IMP IMP: Inferred from mutant phenotype	25467444	GOA
located in site of double-strand break	IDA IDA: Inferred from direct assay	25512560	GOA
part of telomerase holoenzyme complex	IDA IDA: Inferred from direct assay	19179534	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

WRAP53 Protein Structure

WD40

0
100
200
300
400
500
548 a.a.

Protein Preferred Names	Protein Names
telomerase Cajal body protein 1	WD repeat-containing protein 79

WRAP53 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	WRAP53	Q9BUR4	VAC14	Homo sapiens	Q08AM6	Y2H Array	32296183
Intra	WRAP53	Q9BUR4	VAC14	Homo sapiens	Q08AM6	Y2H Prey Pooling	32296183
Intra	WRAP53	Q9BUR4	UBAP2	Homo sapiens	Q5T6F2	Y2H Array	32296183
Intra	WRAP53	Q9BUR4	UBAP2	Homo sapiens	Q5T6F2	Y2H Prey Pooling	32296183
Intra	WRAP53	Q9BUR4	DKC1	Homo sapiens	O60832	Anti Bait CoIP	19179534
Intra	WRAP53	Q9BUR4	CCT2	Homo sapiens	P78371	Anti Bait CoIP	25467444
Intra	WRAP53	Q9BUR4	CCT3	Homo sapiens	P49368	Anti Tag CoIP	25467444
Intra	WRAP53	Q9BUR4	CCT2	Homo sapiens	P78371	Anti Tag CoIP	25467444
Intra	WRAP53	Q9BUR4	CCT3	Homo sapiens	P49368	Anti Bait CoIP	25467444
Intra	WRAP53	Q9BUR4	TCP1	Homo sapiens	P17987	Anti Tag CoIP	25467444
Intra	WRAP53	Q9BUR4	CCT3	Homo sapiens	P49368	Anti Tag CoIP	26496610
Intra	WRAP53	Q9BUR4	DKC1	Homo sapiens	O60832	Anti Tag CoIP	25467444
Intra	WRAP53	Q9BUR4	CCT2	Homo sapiens	P78371	Anti Tag CoIP	26496610
Intra	WRAP53	Q9BUR4	TCP1	Homo sapiens	P17987	Anti Bait CoIP	25467444
Intra	WRAP53	Q9BUR4	DKC1	Homo sapiens	O60832	Anti Tag CoIP	26496610
Intra	WRAP53	Q9BUR4	SMN1	Homo sapiens	Q16637	Anti Bait CoIP	21072240
Intra	WRAP53	Q9BUR4	SMN1	Homo sapiens	Q16637	Anti Tag CoIP	21072240
Intra	WRAP53	Q9BUR4	COIL	Homo sapiens	P38432	Anti Bait CoIP	21072240
Intra	WRAP53	Q9BUR4	COIL	Homo sapiens	P38432	Anti Tag CoIP	21072240
Cross	WRAP53	Q9BUR4	CCT6	Oryctolagus cuniculus	O77622	Anti Tag CoIP	25467444

Cross: Cross-species interaction Intra: Intraspecies interaction

WRAP53 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P85481	WDR79 Antibody (YA5173)	WB, ICC/IF, IP, ELISA, IF-Tissue	Human

Related Diseases

Diseases	Alias
Dyskeratosis Congenita, Autosomal Recessive 3	DKCB3 Autosomal Recessive Dyskeratosis Congenita 3 Dyskeratosis Congenita, Autosomal Recessive, 3 Dyskeratosis Congenita, Autosomal Recessive, Type 3
Li-Fraumeni Syndrome	Sarcoma Family Syndrome Of Li And Fraumeni Sbla Syndrome LFS Li-Fraumeni Familiar Cancer Susceptibility Syndrome Sarcoma, Breast, Leukaemia And Adrenal Gland Syndrome Lfs1 Li Fraumeni Syndrome Sarcoma, Breast, Leukemia, And Adrenal Gland Syndrome Lfl Sbla Syndrome Li-Fraumeni-Like Syndrome Li-Fraumeni Syndrome 1
Dyskeratosis Congenita	Dyskeratosis Congenita Autosomal Dominant Dc Dkc Zinsser-Engman-Cole Syndrome Dyskeratosis Congenita, Autosomal Dominant Autosomal Dominant Dyskeratosis Congenita Dkca Dyskeratosis Congenita Scoggins Type Zinsser-Cole-Engman Syndrome X-Linked Dyskeratosis Congenita Hoyeraal-Hreidarsson Syndrome
Hepatocellular Carcinoma	Liver Cancer Primary Liver Cancer HCC Hepatoma Malignant Neoplasm Of Liver Liver Neoplasms Cancer, Hepatocellular Liver Cell Carcinoma Lcc Hepatoblastoma, Somatic Hepatic Cancer Primary Malignant Neoplasm Of Liver Rare Tumor Of Liver And Intrahepatic Biliary Tract Hepatocellular Carcinoma, Somatic Hepatocellular Carcinoma, Childhood Type, Somatic Hepatocellular Cancer, Somatic Ca Liver - Primary Hepatic Neoplasm Malignant Hepato-Biliary Neoplasm Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary Malignant Neoplasm Of Liver, Primary Malignant Tumor Of Liver Neoplasm Of Liver Non-Resectable Primary Hepatic Malignant Neoplasm Resectable Malignant Neoplasm Of Liver Resectable Malignant Neoplasm Of The Liver Primary Liver Carcinoma Primary Malignant Liver Neoplasm Primary Cancer Of Liver Primary Tumor Of The Liver Rare Tumor Of Liver And Ibt Hepatocellular Cancer Neoplasm Of The Liver Carcinoma, Hepatocellular Hepatomas Liver Neoplasm Liver Carcinoma Liver And Intrahepatic Biliary Tract Carcinoma Malignant Hepatobiliary Neoplasm Adult Primary Hepatocellular Carcinoma Hepatoblastoma Carcinoma Of Liver Malignant Liver Tumour Malignant Hepatic Tumour
Revesz Syndrome	Exudative Retinopathy With Bone Marrow Failure DKCA5 Dyskeratosis Congenita, Autosomal Dominant 5 Dyskeratosis Congenita With Bilateral Exudative Retinopathy Retinopathy-Anemia-Central Nervous System Anomalies Syndrome Revesz-Debuse Syndrome Dyskeratosis Congenita, Autosomal Dominant, 5 Revesz Debuse Syndrome
Dyskeratosis Congenita Autosomal Recessive	Autosomal Recessive Dyskeratosis Congenita Dkcb Dyskeratosis Congenita, Autosomal Recessive
Aplastic Anemia	Aplastic Anemia, Susceptibility To Anemia Aplastic Idiopathic Aplastic Anemia Secondary Aplastic Anemia Idiopathic Bone Marrow Failure Aplastic Anemia Idiopathic AA Anemia, Aplastic Aplastic Anemia, Idiopathic Erythroid Aplasia Aa - [Aplastic Anaemia] Haematopoietic Aplasia Aleukia Haemorrhagica Anaemia Due To Decreased Red Cell Production Aplasia Bone Marrow Aplastic Bone Marrow Hypoplastic Anaemia Nos Myeloid Bone Marrow Aplasia Pancytopenia Panhaematopenia Hypoproliferative Anaemia Medullary Hypoplasia Red Blood Cells Hypoplastic Anaemia Panmyelophthisis Panhemocytopenia Refractive Hypoproliferative Anaemia Toxic Anaemia Toxic Aplastic Anaemia Aplastic Anaemia Due To Toxic Cause Idiopathic Aplastic Anaemia Nos
Dyskeratosis Congenita, Autosomal Dominant 1	DKCA1 Dyskeratosis Congenita, Scoggins Type Autosomal Dominant Dyskeratosis Congenita 1 Dyskeratosis Congenita, Autosomal Dominant, Type 1 Dyskeratosis Congenita, Autosomal Dominant
Retinal Telangiectasia
Coats Disease	Exudative Retinopathy Retinal Telangiectasis Coats' Disease Leber Miliary Aneurysm Coats' Syndrome Congenital Retinal Telangiectasia
Entropion
Melanoma, Cutaneous Malignant 1	Familial Melanoma Melanoma, Cutaneous Malignant, Susceptibility To, 1 Melanoma, Malignant CMM1 Melanoma, Cutaneous Malignant Cmm Familial Atypical Mole-Malignant Melanoma Syndrome Fammm Melanoma, Familial Mlm Dysplastic Nevus Syndrome, Hereditary Dns B-K Mole Syndrome Melanoma, Cutaneous Malignant, 1 Malignant Melanoma, Cutaneous Melanoma, Cutaneous, Malignant, Susceptibility To, Type 1 Dysplastic Nevus Syndrome Cutaneous Melanoma Familial Atypical Mole Melanoma Syndrome Hereditary Melanoma
Diamond-Blackfan Anemia	Congenital Pure Red Cell Aplasia Aase Syndrome Erythrogenesis Imperfecta Anemia, Diamond-Blackfan Congenital Hypoplastic Anemia Aase-Smith Ii Syndrome Bds Blackfan-Diamond Anemia Congenital Prca Congenital Hypoplastic Anemia, Blackfan-Diamond Type Dba Blackfan - Diamond Syndrome Chronic Constitutional Pure Red Cell Anaemia Anemia Diamond Blackfan Type Anemia Congenital Erythroid Hypoplastic Aregenerative Anemia Chronic Congenital Blackfan Diamond Syndrome Red Cell Aplasia, Pure Hereditary Aase-Smith Syndrome Ii Bda Blackfan Diamond Anemia Blackfan-Diamond Disease Blackfan-Diamond Syndrome Chronic Congenital Agenerative Anemia Congenital Erythroid Hypoplastic Anemia Congenital Hypoplastic Anemia Of Blackfan And Diamond Congenital Pure Red Cell Anemia Hypoplastic Congenital Anemia Inherited Erythroblastopenia Pure Hereditary Red Cell Aplasia Anemia, Hypoplastic, Congenital Anemia Hypoplastic Congenital Fanconi Anemia Constitutional Aplastic Anemia Diamond-Blackfan Anemia 1 Aase Smith Syndrome 2 Congenital Red Cell Aplasia Red Cell Aplasia Of Infants Pure Red Cell Aplasia Of Infants Congenital Red Cell Aplastic Anaemia Congenital Pure Red Cell Anaemia Congenital Erythroid Hypoplasia Pearson Marrow-Pancreas Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15846	WRAP53 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	WRAP53	VGNC	VGNC:79508
Bos taurus	WRAP53	VGNC	VGNC:36968
Rattus norvegicus	WRAP53	RGD	RGD:1359624
Canis familiaris	WRAP53	VGNC	VGNC:48432
Mus musculus	WRAP53	MGD	MGI:2384933
Felis catus	WRAP53	VGNC	VGNC:67088
Others	WRAP53	NCBI