RNF130 - ring finger protein 130 Gene

Also Known as GP; G1RP; G1RZFP; GOLIATH

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 55819

About RNF130

Cytogenetic location: 5q35.3 Genomic coordinates (GRCh38): 5:179,911,651-180,071,759 (from NCBI)

This gene has 8 transcripts (splice variants), 212 orthologues and 9 paralogues. Ubiquitous expression in fat (RPKM 11.3), brain (RPKM 9.7) and 25 other tissues.

Summary

The protein encoded by this gene contains a RING finger motif and is similar to g1, a Drosophila zinc-finger protein that is expressed in mesoderm and involved in embryonic development. The expression of the mouse counterpart was found to be upregulated in myeloblastic cells following IL3 deprivation, suggesting that this gene may regulate growth factor withdrawal-induced Apoptosis of myeloid precursor cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

RNF130 Products (3)

mRNA	Protein	Name
NM_001280801.2	NP_001267730.1	E3 ubiquitin-protein ligase RNF130 isoform 2 precursor
NM_001410829.1	NP_001397758.1	E3 ubiquitin-protein ligase RNF130 isoform 3 precursor
NM_018434.6	NP_060904.2	E3 ubiquitin-protein ligase RNF130 isoform 1 precursor

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables ubiquitin-protein transferase activity	IDA IDA: Inferred from direct assay	16549277	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	16549277	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RNF130 Protein Structure

PA

zf-RING_2

0
100
200
300
400
419 a.a.

Protein Preferred Names	Protein Names
E3 ubiquitin-protein ligase RNF130	RING-type E3 ubiquitin transferase RNF130

Related Diseases

Diseases	Alias
Pilocytic Astrocytoma Of Cerebellum	Cerebellar Pilocytic Astrocytoma
Cerebellar Astrocytoma	Astrocytoma Of Cerebellum
Pilomyxoid Astrocytoma
Cerebellum Cancer	Cerebellar Neoplasms Cerebellar Cancer Malignant Tumor Of Cerebellum Malignant Neoplasm Of Cerebellum
Dysembryoplastic Neuroepithelial Tumor	Dysembryoplastic Neuroepithelial Tumour Dysembryoplastic Neuroepithelial Neoplasm Dnet
Papillary Craniopharyngioma	Craniopharyngioma, Papillary Papillary Rathke'S Pouch Tumor Craniopharyngioma Papillary
Childhood Pilocytic Astrocytoma	Pediatric Pilocytic Astrocytoma
Pilocytic Astrocytoma	Juvenile Pilocytic Astrocytoma Grade I Astrocytic Tumor Piloid Astrocytoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12048	RNF130 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	RNF130	VGNC	VGNC:64670
Bos taurus	RNF130	VGNC	VGNC:34021
Macaca mulatta	RNF130	VGNC	VGNC:76764
Mus musculus	RNF130	MGD	MGI:1891717
Rattus norvegicus	RNF130	RGD	RGD:1562041
Canis familiaris	RNF130	VGNC	VGNC:45630