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RPL22 - ribosomal protein L22 Gene

Also Known as EAP; L22; HBP15; HBP15/L22

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 6146

About RPL22

Cytogenetic location: 1p36.31 Genomic coordinates (GRCh38): 1:6,185,020-6,199,595 (from NCBI)

This gene has 7 transcripts (splice variants), 194 orthologues, 1 paralogue and is associated with 47 phenotypes. Ubiquitous expression in ovary (RPKM 336.6), endometrium (RPKM 190.1) and 25 other tissues.

Summary

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a cytoplasmic ribosomal protein that is a component of the 60S subunit. The protein belongs to the L22E family of ribosomal proteins. Its initiating methionine residue is post-translationally removed. The protein can bind specifically to Epstein-Barr virus-encoded RNAs (EBERs) 1 and 2. The mouse protein has been shown to be capable of binding to heparin. Transcript variants utilizing alternative polyA signals exist. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. It was previously thought that this gene mapped to 3q26 and that it was fused to the acute myeloid leukemia 1 (AML1) gene located at 21q22 in some therapy-related myelodysplastic syndrome patients with 3;21 translocations; however, these fusions actually involve a ribosomal protein L22 pseudogene located at 3q26, and this gene actually maps to 1p36.3-p36.2. [provided by RefSeq, Jul 2008]

RPL22 Products (1)

mRNA	Protein	Name
NM_000983.4	NP_000974.1	60S ribosomal protein L22

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11145900	GOA
enables structural constituent of ribosome	IDA IDA: Inferred from direct assay	23636399	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	8135813	GOA
part of cytosolic large ribosomal subunit	IDA IDA: Inferred from direct assay	32669547	GOA
located in cytosolic ribosome	IDA IDA: Inferred from direct assay	23636399	GOA
located in nucleus	IDA IDA: Inferred from direct assay	22720776	GOA
part of ribonucleoprotein complex	IDA IDA: Inferred from direct assay	18809582	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RPL22 Protein Structure

Ribosomal_L22e

0
100
128 a.a.

Protein Preferred Names	Protein Names
60S ribosomal protein L22	EBER-associated protein

RPL22 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	RPL22	P35268	BEND7	Homo sapiens	Q8N7W2-2	Validated Y2H	32296183
Intra	RPL22	P35268	BEND7	Homo sapiens	Q8N7W2-2	Y2H Prey Pooling	32296183
Intra	RPL22	P35268	BEND7	Homo sapiens	Q8N7W2-2	Y2H Array	32296183
Intra	RPL22	P35268	FGF11	Homo sapiens	Q92914	Y2H Prey Pooling	32296183
Intra	RPL22	P35268	FGF11	Homo sapiens	Q92914	Validated Y2H	32296183
Intra	RPL22	P35268	FGF11	Homo sapiens	Q92914	Y2H Array	32296183
Intra	RPL22	P35268	CT45A1	Homo sapiens	Q5HYN5	Y2H Prey Pooling	32296183
Intra	RPL22	P35268	CT45A1	Homo sapiens	Q5HYN5	Validated Y2H	32296183
Intra	RPL22	P35268	CT45A1	Homo sapiens	Q5HYN5	Y2H Array	32296183
Intra	RPL22	P35268	H2BC15	Homo sapiens	U3KQK0	Validated Y2H	32296183
Intra	RPL22	P35268	H2BC15	Homo sapiens	U3KQK0	Y2H Array	32296183
Intra	RPL22	P35268	H2BC15	Homo sapiens	U3KQK0	Y2H Prey Pooling	32296183
Intra	RPL22	P35268	SURF6	Homo sapiens	O75683	Y2H Array	32296183
Intra	RPL22	P35268	SURF6	Homo sapiens	O75683	Y2H Prey Pooling	32296183
Intra	RPL22	P35268	AP2M1	Homo sapiens	Q96CW1	Y2H Prey Pooling	32296183
Intra	RPL22	P35268	AP2M1	Homo sapiens	Q96CW1	Validated Y2H	32296183
Intra	RPL22	P35268	AP2M1	Homo sapiens	Q96CW1	Y2H Array	32296183
Intra	RPL22	P35268	SDCBP2	Homo sapiens	Q9H190	BFG-2H	27107012
Intra	RPL22	P35268	SDCBP2	Homo sapiens	Q9H190	Y2H Array	32296183
Intra	RPL22	P35268	ATXN1	Homo sapiens	P54253	Validated Y2H	32814053
Intra	RPL22	P35268	ATXN1	Homo sapiens	P54253	Y2H Pooling	32814053
Intra	RPL22	P35268	SDCBP	Homo sapiens	O00560	BFG-2H	27107012
Intra	RPL22	P35268	SDCBP	Homo sapiens	O00560	Y2H Array	32296183
Intra	RPL22	P35268	ATXN1	Homo sapiens	P54253	Y2H Array	32814053
Intra	RPL22	P35268	SDCBP	Homo sapiens	O00560	Validated Y2H	27107012
Intra	RPL22	P35268	SDCBP2	Homo sapiens	Q9H190	Y2H Prey Pooling	32296183
Intra	RPL22	P35268	SDCBP2	Homo sapiens	Q9H190	Validated Y2H	32296183
Intra	RPL22	P35268	SDCBP	Homo sapiens	O00560	Y2H Prey Pooling	32296183
Intra	RPL22	P35268	HTT	Homo sapiens	P42858	Y2H Pooling	32814053
Intra	RPL22	P35268	HTT	Homo sapiens	P42858	Validated Y2H	32814053
Intra	RPL22	P35268	HTT	Homo sapiens	P42858	Y2H Array	32814053
Intra	RPL22	P35268	ZCCHC10	Homo sapiens	Q8TBK6	Y2H Prey Pooling	32296183
Intra	RPL22	P35268	ZCCHC10	Homo sapiens	Q8TBK6	Validated Y2H	32296183
Intra	RPL22	P35268	ZCCHC10	Homo sapiens	Q8TBK6	Y2H Array	32296183
Intra	RPL22	P35268	THAP1	Homo sapiens	Q9NVV9	Y2H Prey Pooling	32296183
Intra	RPL22	P35268	THAP1	Homo sapiens	Q9NVV9	Validated Y2H	32296183
Intra	RPL22	P35268	THAP1	Homo sapiens	Q9NVV9	Y2H Array	32296183
Intra	RPL22	P35268	DDIT4L	Homo sapiens	Q96D03	Validated Y2H	32296183
Intra	RPL22	P35268	DDIT4L	Homo sapiens	Q96D03	Y2H Prey Pooling	32296183
Intra	RPL22	P35268	DDIT4L	Homo sapiens	Q96D03	Y2H Array	32296183
Intra	RPL22	P35268	STAC3	Homo sapiens	Q96MF2	Y2H Prey Pooling	32296183
Intra	RPL22	P35268	STAC3	Homo sapiens	Q96MF2	Validated Y2H	32296183
Intra	RPL22	P35268	STAC3	Homo sapiens	Q96MF2	Y2H Array	32296183
Cross	RPL22	P35268	IE	Equine herpesvirus 1	P17473	Pull Down	11145900

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Sexual Masochism	Masochism
Colon Sarcoma	Colonic Sarcoma
Myelodysplastic Syndrome	Myelodysplastic Syndromes Myelodysplasia MDS Myelodysplastic Syndrome Included Myelodysplastic Syndrome, Susceptibility To, Included Myelodysplastic Syndrome, Somatic Myelodysplastic Syndrome, Susceptibility To
Diamond-Blackfan Anemia	Congenital Pure Red Cell Aplasia Aase Syndrome Erythrogenesis Imperfecta Anemia, Diamond-Blackfan Congenital Hypoplastic Anemia Aase-Smith Ii Syndrome Bds Blackfan-Diamond Anemia Congenital Prca Congenital Hypoplastic Anemia, Blackfan-Diamond Type Dba Blackfan - Diamond Syndrome Chronic Constitutional Pure Red Cell Anaemia Anemia Diamond Blackfan Type Anemia Congenital Erythroid Hypoplastic Aregenerative Anemia Chronic Congenital Blackfan Diamond Syndrome Red Cell Aplasia, Pure Hereditary Aase-Smith Syndrome Ii Bda Blackfan Diamond Anemia Blackfan-Diamond Disease Blackfan-Diamond Syndrome Chronic Congenital Agenerative Anemia Congenital Erythroid Hypoplastic Anemia Congenital Hypoplastic Anemia Of Blackfan And Diamond Congenital Pure Red Cell Anemia Hypoplastic Congenital Anemia Inherited Erythroblastopenia Pure Hereditary Red Cell Aplasia Anemia, Hypoplastic, Congenital Anemia Hypoplastic Congenital Fanconi Anemia Constitutional Aplastic Anemia Diamond-Blackfan Anemia 1 Aase Smith Syndrome 2 Congenital Red Cell Aplasia Red Cell Aplasia Of Infants Pure Red Cell Aplasia Of Infants Congenital Red Cell Aplastic Anaemia Congenital Pure Red Cell Anaemia Congenital Erythroid Hypoplasia Pearson Marrow-Pancreas Syndrome
Shwachman-Diamond Syndrome 1	Shwachman-Diamond Syndrome Shwachman Syndrome Shwachman-Bodian-Diamond Syndrome Sds Pancreatic Insufficiency And Bone Marrow Dysfunction Shwachman-Bodian Syndrome SDS1 Lipomatosis Of Pancreas, Congenital Congenital Lipomatosis Of Pancreas Shwachman-Diamond Type Metaphyseal Dysplasia Metaphyseal Chondrodysplasia, Shwachman Type Shwachman-Diamond-Oski Syndrome
Dyskeratosis Congenita	Dyskeratosis Congenita Autosomal Dominant Dc Dkc Zinsser-Engman-Cole Syndrome Dyskeratosis Congenita, Autosomal Dominant Autosomal Dominant Dyskeratosis Congenita Dkca Dyskeratosis Congenita Scoggins Type Zinsser-Cole-Engman Syndrome X-Linked Dyskeratosis Congenita Hoyeraal-Hreidarsson Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12173	RPL22 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS12174	RPL22L1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	RPL22	RGD	RGD:621189
Bos taurus	RPL22	VGNC	VGNC:101450
Mus musculus	RPL22	MGD	MGI:99262
Others	RPL22	NCBI