SEMG2 - semenogelin 2 Gene

Also Known as SGII

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 6407

About SEMG2

Cytogenetic location: 20q13.12 Genomic coordinates (GRCh38): 20:45,221,373-45,224,458 (from NCBI)

This gene has 1 transcript (splice variant), 39 orthologues and 1 paralogue. Low expression observed in reference dataset.

Summary

The secreted protein encoded by this gene is involved in the formation of a gel matrix that encases ejaculated spermatozoa. Proteolysis by the prostate-specific antigen (PSA) breaks down the gel matrix and allows the spermatozoa to move more freely. The encoded protein is found in lesser abundance than a similar semenogelin protein. An Antibacterial activity has been found for a antimicrobial peptide isolated from this protein. The genes encoding these two semenogelin proteins are found in a cluster on chromosome 20. [provided by RefSeq, Jan 2015]

SEMG2 Products (1)

mRNA Protein Name
NM_003008.3 NP_002999.1 semenogelin-2 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protease binding IPI
IPI: Inferred from physical interaction
8665956 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
8665956 GOA
enables zinc ion binding IMP
IMP: Inferred from mutant phenotype
15563730 GOA
Biological Process GO Annotation Evidence References Source
involved in antibacterial humoral response IMP
IMP: Inferred from mutant phenotype
18714013 GOA
involved in coagulation IDA
IDA: Inferred from direct assay
8665956 GOA
involved in positive regulation of serine-type endopeptidase activity IDA
IDA: Inferred from direct assay
15563730 GOA
Cellular Component GO Annotation Evidence References Source
located in extracellular space IDA
IDA: Inferred from direct assay
8665951 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SEMG2 Protein Structure

Semenogelin

Semenogelin: Semenogelin (1 - 582)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 582 a.a.
Protein Preferred Names Protein Names

semenogelin-2

  • semenogelin II

Related Diseases

Diseases Alias
Pelvic Varices

  • Varix Of Pelvis

  • Pelvic Varicose Vein
Atrial Septal Defect 9

  • ASD9

  • Atrial Heart Septal Defect 9

  • Septal Defect, Atrial, Type 9
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12670 SEMG2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta SEMG2 VGNC VGNC:77173
Others SEMG2 NCBI